AOPs

OECD View API
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Showing 101 to 125 of 555 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
91 Sodium channel inhibition leading to reduced survival Kellie Fay BY-SA 584: Inhibition, sodium channel
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay BY-SA 638: Antagonism, Histamine Receptor (H2)
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay BY-SA 598: modulation, sodium channel 351: Increased Mortality
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 877: Inhibition, organic anion transporter 1 (OAT1)
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay BY-SA 584: Inhibition, sodium channel None
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population
186 unknown MIE leading to renal failure and mortality Kellie Fay BY-SA 1114: Unknown, MIE 351: Increased Mortality
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 1103: Inhibition, Cyclooxygenase 1 activity
524 Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals Antonio Fernandez Dumont BY-SA 2257: Celiac disease Under Review 1.98
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska BY-SA 1739: Binding to ACE2 None
526 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis John Frisch BY-SA None 1758: Impaired, Spermatogenesis
527 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased John Frisch BY-SA None 2082: Hypospadias, increased
528 Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis John Frisch BY-SA None 1616: Malformation, cryptorchidism - maldescended testis
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
517 Pregnane X Receptor (PXR) activation leads to liver steatosis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 459: Increase, Liver steatosis
518 Liver X Receptor (LXR) activation leads to liver steatosis John Frisch BY-SA 167: Activation, LXR 459: Increase, Liver steatosis
545 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
548 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
539 Decreased Sodium/Potassium ATPase activity leads to Heart failure John Frisch BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
609 Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 1075: prolonged, estrus cycle
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding John Frisch BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding