AOPs

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Showing 101 to 125 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2415: Precocious puberty
622 Calcineurin inhibitor induced nephrotoxicity leading to kidney failure Kate Liang BY-SA None 759: Increased, Kidney Failure
623 Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2306: Persistent vaginal cornification
624 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
625 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA None 1786: Nipple retention (NR), increased
576 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1786: Nipple retention (NR), increased
577 AhR activation leading to endometriosis Léna CAUDAL BY-SA 18: Activation, AhR None
578 AhR activation leading to cancer progression via immunosuppression Léo SPORTES-MILOT BY-SA 18: Activation, AhR 1971: Increased, tumor growth
579 Transthyretin disruption in developing fish leading to projected decline in fish population Adriana Webb BY-SA None None
606 Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1 You Song BY-SA 2374: Increase, Ecdysone receptor antagonism
609 Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 1075: prolonged, estrus cycle
611 Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes Donggon Yoo BY-SA 2379: Disruption of the regulatory function of dopamine signaling components. 2382: Increase, nerve spasm
612 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
613 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
614 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
618 PPARgamma activation leads to a diminished vaccine response Léo SPORTES-MILOT BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation 2397: Diminished vaccine response
619 Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues Travis Karschnik BY-SA 26: Antagonism, Androgen receptor 2401: Male preputial separation, failed/delayed
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim BY-SA 1799: Inhibition of 11β-HSD 360: Decrease, Population growth rate Under Development 1.93
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim BY-SA 1796: 11β-hydroxylase inhibition 360: Decrease, Population growth rate Under Development 1.93
358 Chitinase inhibition leading to mortality Simon Schmid BY-SA 1806: Inhibition, Chitinase 350: Increase, Mortality Under Development 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid BY-SA 1807: Inhibition, Chitobiase 350: Increase, Mortality Under Development 1.94
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid BY-SA 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality WPHA/WNT Endorsed 1.94