AOPs

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Showing 101 to 125 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Undefined BY-SA 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Undefined BY-SA 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Undefined BY-SA 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle John Frisch BY-SA 1065: Activation, estrogen receptor alpha 406: decreased, Fertility
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2418: Increased, phenotypic female-biased sex ratio
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
622 Calcineurin inhibitor induced nephrotoxicity leading to kidney failure Kate Liang BY-SA None 759: Increased, Kidney Failure
623 Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2306: Persistent vaginal cornification
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA None 1786: Nipple retention (NR), increased
576 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1786: Nipple retention (NR), increased
577 AhR activation leading to endometriosis Léna CAUDAL BY-SA 18: Activation, AhR None
578 AhR activation leading to cancer progression via immunosuppression Léo SPORTES-MILOT BY-SA 18: Activation, AhR 1971: Increased, tumor growth
579 Transthyretin disruption in developing fish leading to projected decline in fish population Adriana Webb BY-SA None None
580 Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index Théo Jamay All rights reserved 2331: Activation, Mineralocorticoid Receptor 2335: Increase, body mass index
581 Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease Marie-Gabrielle Zurich All rights reserved 122: Increase, Glucocorticoid receptor activation 402: Cognitive function, decreased
582 Inhibition of EphA2 phosphorylation leads to liver damage via the ERK/ MDM2/p53 axis Peihua Luo All rights reserved None None
583 Vascular endothelial HER2 inhibition disrupts cardiomyocyte calcium homeostasis via EGFR/STAT3/PTX3 axis leading to cardiac contractile dysfunction Peihua Luo All rights reserved None None
584 SQLE accumulation leads to hepatotoxicity via cholesterol/sphingolipid metabolic disturbance and lysosomal damage Peihua Luo All rights reserved None None
585 AKT Inhibition blocks the autophagy flow through the PRKAA/AMPK pathway and leads to cardiotoxicity Peihua Luo All rights reserved None None
586 The increasing accumulation of HMGB1 in the nucleus causes cardiomyocyte death via HMGB1/HSPB1/CCN2 pathway Peihua Luo All rights reserved None None
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
605 Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim BY-SA 279: Thyroperoxidase, Inhibition
604 Binding of Alpha 1-Adrenergics to Agonists Leading to Depression LUANA GOMES All rights reserved 2370: Agonism binding, α1-Adrenoreceptor 1346: Increased, depression
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth