AOPs

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Showing 126 to 150 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
104 Altered ion channel activity leading impaired heart function Undefined BY-SA 697: impaired, ion channels 351: Increased Mortality
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA 714: Increased, Binding of chemicals to 2u (serum) 713: Increase, Adenomas/carcinomas (renal tubular)
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Undefined BY-SA 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Knut Erik Tollefsen BY-SA 103: Increase, Ecdysone receptor hyperactivation
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption 51: Inhibition, Ca++ ATPase 1392: Increase, Oxidative Stress
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve BY-SA 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
29 Estrogen receptor agonism leading to reproductive dysfunction Undefined BY-SA 111: Agonism, Estrogen receptor
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Undefined BY-SA None None
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption 9: Activation, 5HT2c 759: Increased, Kidney Failure
34 LXR activation leading to hepatic steatosis Undefined BY-SA 345: N/A, Liver Steatosis
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Undefined BY-SA 111: Agonism, Estrogen receptor 417: skewed, sex ratio
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA 111: Agonism, Estrogen receptor None
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA 18: Activation, AhR 459: Increase, Liver steatosis
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA 461: Suppression, HNF4alpha None
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Undefined BY-SA 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Undefined BY-SA 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Undefined BY-SA 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility