AOPs

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Showing 151 to 175 of 556 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 424: Inhibition, Na+/I- symporter (NIS) 1101: Altered, Amphibian metamorphosis
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 279: Thyroperoxidase, Inhibition 1101: Altered, Amphibian metamorphosis
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 957: Binding, Transthyretin in serum 1101: Altered, Amphibian metamorphosis
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1831: Binding, Thyroid binding globulin in serum 1101: Altered, Amphibian metamorphosis
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA 18: Activation, AhR None WPHA/WNT Endorsed 1.27
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA None None Under Development 1.79
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang BY-SA 1065: Activation, estrogen receptor alpha 1991: Impaired, Reproduction
580 Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index Théo Jamay All rights reserved 2331: Activation, Mineralocorticoid Receptor 2335: Increase, body mass index
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
421 PPARG activation leading to intrahepatic cholestasis Yuan Jin BY-SA None None
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno BY-SA 245: Activation, PXR/SXR None Under Development 2.5
619 Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues Travis Karschnik BY-SA 26: Antagonism, Androgen receptor 2401: Male preputial separation, failed/delayed
521 Essential element imbalance leads to reproductive failure via oxidative stress Travis Karschnik BY-SA 2205: Increased, essential element imbalance 2147: Decreased, Viable Offspring
499 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
167 Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells Travis Karschnik BY-SA 111: Agonism, Estrogen receptor 1070: Increased, adenosquamous carcinomas of endometrium