AOPs

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Showing 151 to 175 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Kalyan Gayen BY-SA 1046: Suppression, Estrogen receptor (ER) activity Under Development 1.104
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA None None
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman BY-SA 896: Parkinsonian motor deficits
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1276: Lung fibrosis
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA 1817: Apoptotic cell death
421 PPARG activation leading to intrahepatic cholestasis Yuan Jin BY-SA None None
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu BY-SA None 1250: Decrease, Lung function
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu BY-SA None None
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive function, decreased
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic BY-SA 1647: GSK3beta inactivation
409 Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark BY-SA 1668: Frustrated phagocytosis 1090: Increased, mesotheliomas