AOPs

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Showing 176 to 200 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li BY-SA None None
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1967: Pyroptosis
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 1970: transposition of the great arteries
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA None None
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN BY-SA None 759: Increased, Kidney Failure
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA None None
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang BY-SA 1065: Activation, estrogen receptor alpha 1991: Impaired, Reproduction
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton BY-SA 360: Decrease, Population growth rate
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT BY-SA 1686: Deposition of Energy 1978: Increase risk, microcephaly
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang BY-SA None None
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
435 Deposition of ionising energy leads to population decline via pollen abnormal Li Xie BY-SA 1686: Deposition of Energy
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout BY-SA None None
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede BY-SA 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang BY-SA 1950: Increase, TNF 1953: Gestational diabetes mellitus
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen BY-SA None 1941: Memory Loss
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1535: Heart failure
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1934: Myocardial Infarction
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARĪ±
324 Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
325 Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
326 Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth