AOPs

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Showing 176 to 200 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Kevin Brix BY-SA 1115: Increase, Reactive oxygen species 360: Decrease, Population growth rate
541 Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching Ruiyang Ding BY-SA None None
543 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
544 Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
545 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
546 Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
547 Androgen receptor agonism leading to long anogenital distance in female offspring Johanna Zilliacus All rights reserved 25: Agonism, Androgen receptor 2365: Anogenital distance (AGD), increased
548 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
549 Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish Hongling Liu BY-SA 36: Inhibition, Aromatase
550 Increased LMNA gene mutation leading to heart failure Young Jun Kim BY-SA 2278: Increased LMNA Mutation 1535: Heart failure
551 Increased Muscarinic M2 Receptor leading to Arrhythmia Young Jun Kim Open for adoption 1602: Increased Muscarinic Acetylcholine Receptors 1106: Occurrence, cardiac arrhythmia
552 Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) Young Jun Kim BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure
553 Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure Young Jun Kim BY-SA 584: Inhibition, sodium channel 1535: Heart failure
554 β-adrenergic receptor agonists leading to arrhythmias. Young Jun Kim BY-SA 1038: Activation, beta-2 adrenergic receptor 1106: Occurrence, cardiac arrhythmia
528 Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis John Frisch BY-SA None 1616: Malformation, cryptorchidism - maldescended testis
529 Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis Erik Mylroie BY-SA 2226: Stressor binding PPAR isoforms 459: Increase, Liver steatosis
530 Endocytotic lysosomal uptake leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA 1539: Endocytotic lysosomal uptake 1931: Intestinal barrier, disruption
531 VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction Hui Li BY-SA None None
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 2231: Locomotor function. Impaired
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2232: Antagonism, Retinoic acid receptors 341: Impairment, Learning and memory
534 Succinate dehydrogenase (SDH) inhibition leads to oxidative stress Xavier COUMOUL BY-SA 2118: Succinate dehydrogenase, inhibited 1392: Increase, Oxidative Stress
535 Binding and activation of GPER leading to learning and memory impairments Zedong Ouyang BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 341: Impairment, Learning and memory
536 Estrogen receptor agonism leading to reduced survival and population growth due to renal failure Camille Baettig BY-SA 111: Agonism, Estrogen receptor None
537 Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver Jason M. O'Brien BY-SA 111: Agonism, Estrogen receptor 78: Reduction, Cumulative fecundity and spawning
538 Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways Yanhong Wei BY-SA None 2161: Increase, Vascular disrupting effects