AOPs

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Showing 201 to 225 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
567 Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition Li Xie BY-SA 2307: Binding of plastoquinone B (QB) within D1 protein of Photosystem II
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding John Frisch BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Huimin Ma BY-SA 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA None 2082: Hypospadias, increased
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Young Jun Kim BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
556 Decreased Na/K ATPase activity leading to heart failure Young Jun Kim BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Young Jun Kim BY-SA 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
558 Phosphodiesterase inhibition leading to heart failure Young Jun Kim BY-SA 2288: Phosphodiesterase inhibition 1535: Heart failure
559 Inhibition of acetylcholinesterase (AChE) leading to arrhythmias Young Jun Kim BY-SA 12: Acetylcholinesterase (AchE) Inhibition 1106: Occurrence, cardiac arrhythmia
560 Inhibition of Funny current (If) leading to Arrhythmias Young Jun Kim Open for adoption 2290: Inhibition of Funny current (If) 1106: Occurrence, cardiac arrhythmia
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Martina Panzarea BY-SA 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA None None
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman BY-SA 896: Parkinsonian motor deficits
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 1970: transposition of the great arteries
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA None None
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN BY-SA None 759: Increased, Kidney Failure