AOPs

OECD View API
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Showing 201 to 225 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
614 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
615 Suppression of Keap1 cysteine oxidation leading to liver inflammation Young Jun Kim All rights reserved 2385: Suppression of Keap1 cysteine oxidation 902: Inflammation, Liver
616 organic UV filter and its Photoproducts reproductive toxicity pathways Nataraj Bojan All rights reserved 2391: Reduced fertility / fecundity
617 The adverse outcome pathway of vascular calcification Ruiyang Ding All rights reserved None None
618 PPARgamma activation leads to a diminished vaccine response Léo SPORTES-MILOT BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation 2397: Diminished vaccine response
619 Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues Travis Karschnik BY-SA 26: Antagonism, Androgen receptor 2401: Male preputial separation, failed/delayed
620 The Adverse Outcome Pathway to Deposition of Energy Leading to Female Decreased Fertility Jessica D'Urbano All rights reserved None None
621 NOX2 Driven Oxidative Stress-Induced α-Synuclein Radical Formation and Tau Nitration Leading to Neurodegeneration Tejasvi kumar Open for adoption None None
631 Decreased thyroid hormone receptor beta transcriptional activity leading to MASLD progression via endoplasmic reticulum stress You Song BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) You Song BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) You Song BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) You Song BY-SA None None
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) You Song BY-SA None None
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2413: Increased, uterine weight
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2415: Precocious puberty
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
572 BMP4 Suppression Disrupting Cytoskeletal Remodeling Leading to Neural Tube Closure Defects Job Berkhout BY-SA None None
573 Inhibition, cytochrome oxidase leads to Increased, pulmonary edema John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2316: Increased, pulmonary edema
574 Inhibition, cytochrome oxidase leads to Loss of olfactory function John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2317: Loss of olfactory function
562 HCN Channel Inhibition leading to Arrhythmias Young Jun Kim BY-SA 2295: HCN Channel Inhibition 1106: Occurrence, cardiac arrhythmia
563 Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis Sapana Kushwaha BY-SA 18: Activation, AhR 2305: Premature ovarian Insufficiency
564 DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. lihua Yang BY-SA 1541: Mitochondrial Complex I inhibition
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Martina Panzarea BY-SA 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None