AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen Under development: Not open for comment. Do not cite Under Development
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen Under development: Not open for comment. Do not cite Under Development
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen Under development: Not open for comment. Do not cite Under Development
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen Under development: Not open for comment. Do not cite Under Development
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development b-oxidation fatty acid steatosis 1.29
57 AhR activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development AhR hepatic steatosis 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development CAR hepatic steatosis 1.29
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development HNF4alpha hepatic steatosis 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development PXR hepatic steatosis 1.29
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development multiple hepatic steatosis 1.29
62 AKT2 activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development AKT2 hepatic steatosis 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish Under development: Not open for comment. Do not cite Under Development PPARg adipogenesis 1.29
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders Under development: Not open for comment. Do not cite
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Under development: Not open for comment. Do not cite Under Development unclear energy imbalance
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
215 Molecular events lead to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
217 Gastric ulcer formation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
221 Mental stress to depression Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
222 Mental stress to agitation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
223 Serotonin transporter activation to seizure Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
224 Serotonin transporter activation to depression Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
225 Serotonin transporter activation to agitation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Richard C. Peffer, Ph.D., DABT Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.18
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.54
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi Under development: Not open for comment. Do not cite Under Development
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi Under development: Not open for comment. Do not cite Under Development
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi Under development: Not open for comment. Do not cite Under Development
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi Under development: Not open for comment. Do not cite Under Development
37 PPARalpha-dependent liver cancer Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes EAGMST Approved 1.10
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Under development: Not open for comment. Do not cite Under Development 5-HTT2c kidney toxicity
104 Altered ion channel activity leading impaired heart function Kevin Dreher Under development: Not open for comment. Do not cite Under Development multiple impaired heart function 1.29
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry Under development: Not open for comment. Do not cite Under Development nitric oxide liver tumors
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for comment. Do not cite Included in OECD Work Plan AhR uroporphyria EAGMST Under Review 1.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.7
91 Sodium channel inhibition leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel reduced survival 1.29
93 sodium channel inhibition leading to increased predation Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel increased predation 1.29
94 Sodium channel inhibition leading to congenital malformations Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel congenital malformations 1.29
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Under Development ERG reduced survival 1.29
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel acute mortality 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay Under development: Not open for comment. Do not cite Under Development 5-HTT increased predation 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Under Development H2 reduced survival 1.29
113 Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development GluCl Channel acute mortality 1.29
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay Under development: Not open for comment. Do not cite Under Development HMG-CoA reductase decreased fertility 1.29
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development p-amino hippuric acid renal failure and mortality 1.29
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
186 unknown MIE leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert Under development: Not open for comment. Do not cite Under Development NIS neurodevelopmental outcomes 1.29
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong Open for comment. Do not cite Included in OECD Work Plan GABA epileptic seizures EAGMST Under Review 1.15
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild Under development: Not open for comment. Do not cite
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild Under development: Not open for comment. Do not cite
34 LXR activation leading to hepatic steatosis Marina Goumenou Under development: Not open for comment. Do not cite Under Development LXR liver steatosis
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh Under development: Not open for comment. Do not cite Under Development 5-HTT increased predation 1.29
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for comment. Do not cite Included in OECD Work Plan PPAR starvation-like body-weight loss EAGMST Under Review 2.3
173 Increased substance interaction with the resident cell membrane components leading to lung fibrosis Sabina Halappanavar Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.32
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
21 aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker Open for comment. Do not cite Included in OECD Work Plan AhR embryo toxicity EAGMST Under Review 1.27
29 Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson Under development: Not open for comment. Do not cite Under Development ER reproductive dysfunction 1.29
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson Under development: Not open for comment. Do not cite Under Development ER altered sexual differentiation 1.29
53 ER agonism leading to reduced survival due to renal failure Tom Hutchinson Under development: Not open for comment. Do not cite Under Development ER reduced survival 1.29
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.41
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek Under development: Not open for comment. Do not cite Under Development
240 DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek Under development: Not open for comment. Do not cite Under Development
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Under development: Not open for comment. Do not cite Included in OECD Work Plan case study Under Development 2.5
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Under Development GR modulation of leydig cell function 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Under Development estradiol modulation of leydig cell function 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter Under development: Not open for comment. Do not cite Under Development proteins - undefined modulation of leydig cell function 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter Under development: Not open for comment. Do not cite Under Development multiple modulation of leydig cell function 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter Under development: Not open for comment. Do not cite Under Development modulation of leydig cell function 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter Under development: Not open for comment. Do not cite Under Development GR modulation of leydig cell function 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Under Development unk modulation of leydig cell function 1.29
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
155 Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
156 Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
157 Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
158 Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
159 Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation Under Development 1.47
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Kiyoshi Kushima Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.38
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone Under development: Not open for comment. Do not cite Under Development GR increased disease susceptibility 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development metabolic stress is not MIE colony loss/failure 1.29
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development unk colony loss/failure 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development unclear colony loss/failure 1.29
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development unclear colony loss/failure 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development glucose oxidase colony loss/failure 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone Under development: Not open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
181 Weather event contributes to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Brigitte Landesmann Open for citation & comment Included in OECD Work Plan TFHA/WNT Endorsed 1.1
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws Under development: Not open for comment. Do not cite Under Development GR decreased male fertitlity 1.29
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.50
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
199 ER mediated breast cancer AOP Molly M Morgan Under development: Not open for comment. Do not cite Under Development
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Under development: Not open for comment. Do not cite Under Development
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
258 Renal protein alkylation leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti Under development: Not open for comment. Do not cite Under Development tubulin? aneuploid offspring
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens Under development: Not open for comment. Do not cite
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez Under development: Not open for comment. Do not cite Under Development
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development Prolyl hydroxylase reproductive dysfunction 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development Unknown reproductive dysfunction 1.29
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière Under development: Not open for comment. Do not cite Under Development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière Under development: Not open for comment. Do not cite Under Development
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park Under development: Not open for comment. Do not cite
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Under development: Not open for comment. Do not cite Under Development AR adverse effects in the male foetus
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Under development: Not open for comment. Do not cite Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen Under development: Not open for comment. Do not cite
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for comment. Do not cite Included in OECD Work Plan NIS learning and memory deficits in children EAGMST Under Review 1.28
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.31
259 Sensitization induction of the intestinal tract by food proteins Erwin Roggen Under development: Not open for comment. Do not cite
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Under development: Not open for comment. Do not cite Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Under development: Not open for comment. Do not cite
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
263 Chitin synthase inhibition leading to premature molting associated mortality You Song Under development: Not open for comment. Do not cite
264 Sulfonylurea receptor binding leading to premature molting associated mortality You Song Under development: Not open for comment. Do not cite
265 D1 protein blockage leading to photosystem II (PSII)-inhibition associated growth reduction You Song Under development: Not open for comment. Do not cite
266 D1 protein blockage leading to apoptosis associated growth inhibition You Song Under development: Not open for comment. Do not cite
267 Uncoupling of oxidative phosphorylation leading to mortality You Song Under development: Not open for comment. Do not cite
268 Uncoupling of oxidative phosphorylation leading to reproduction decline You Song Under development: Not open for comment. Do not cite
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker Under development: Not open for comment. Do not cite Under Development DBH reduced fecundity 1.29
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker Under development: Not open for comment. Do not cite Under Development alpha Norad Receptors delayed ovulation 1.29
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker Under development: Not open for comment. Do not cite Under Development 1.29
39 Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
151 AhR signalling leading to placental vascular disruption Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired EAGMST Approved 1.33
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
238 Excessive reactive oxygen species production leading to reduced ATP production-associated reproduction decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite
245 Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition Knut Erik Tollefsen Under development: Not open for comment. Do not cite
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen Open for citation & comment Under Development EcR mortality
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
216 Excessive reactive oxygen species production leading to oocyte apoptosis-associated reproduction decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration EAGMST Approved 1.13
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under development: Not open for comment. Do not cite Included in OECD Work Plan AChE acute mortality Under Development 1.3
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction EAGMST Approved 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive failure 1.29
211 Handbook development AOP Dan Villeneuve Under development: Not open for comment. Do not cite Under Development 1.29
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
205 AOP from chemical insult to cell death Mathieu Vinken Open for comment. Do not cite Under Development
146 Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch Under development: Not open for comment. Do not cite Under Development ER 1.29
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under development: Not open for comment. Do not cite Under Development Alpha2u adenomas and carcinomas 1.29
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development pyruvate dehydrogenase hepatocellular carcinoma 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox is not MIE bronchioloalveolar adenomas and carcinomas 1.29
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under development: Not open for comment. Do not cite Under Development NIS follicular cell adenomas and carcinomas 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood Under development: Not open for comment. Do not cite Under Development AR leydig cell tumors 1.29
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood Under development: Not open for comment. Do not cite Under Development dopamine?? endometrial adenocarcinomas 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood Under development: Not open for comment. Do not cite Under Development HPPD corneal papillomas and carcinomas 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox not MIE forestomach tumors 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox is not MIE renal tubular adenomas and carcinomas 1.29
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox is not MIE hepatocellular adenomas and carcinomas 1.29
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under development: Not open for comment. Do not cite Under Development TPO follicular cell adenomas and carcinomas 1.29
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood Under development: Not open for comment. Do not cite Under Development 5α-reductase leydig cell tumors 1.29
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development unclear urothelial papillomas and carcinomas 1.29
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
212 Histone deacetylase inhibition leading to testicular toxicity Takashi Yamada Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.52
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
220 Cyp2E1 Activation Leading to Liver Cancer Carole Yauk Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.24
139 Alkylation of DNA leading to cancer 1 Carole Yauk Under development: Not open for comment. Do not cite Under Development DNA alkylation cancer
128 Kidney dysfunction by decreased thyroid hormone Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
130 Phospholipase A inhibitors lead to hepatotoxicity Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration Under Development 1.13