AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen Under development: Not open for comment. Do not cite
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen Under development: Not open for comment. Do not cite
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen Under development: Not open for comment. Do not cite
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen Under development: Not open for comment. Do not cite Under Development
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan b-oxidation fatty acid steatosis Under Development 1.29
57 AhR activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan AhR hepatic steatosis Under Development 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan CAR hepatic steatosis Under Development 1.29
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan HNF4alpha hepatic steatosis Under Development 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan PXR hepatic steatosis Under Development 1.29
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple hepatic steatosis Under Development 1.29
62 AKT2 activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan AKT2 hepatic steatosis Under Development 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish Under development: Not open for comment. Do not cite Included in OECD Work Plan PPARg adipogenesis Under Development 1.29
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Under development: Not open for comment. Do not cite Under Development unclear energy imbalance
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic hepatic steatosis (NASH) Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
215 Molecular events lead to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
217 Gastric ulcer formation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
221 Mental stress to depression Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
222 Mental stress to agitation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
223 Serotonin transporter activation to seizure Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
224 Serotonin transporter activation to depression Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
225 Serotonin transporter activation to agitation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Richard C. Peffer, Ph.D., DABT Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.18
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Proposed for OECD Work Plan Proposal submitted - for discussion in June 2017
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans : Case study on silver nanoparticle Jinhee Choi Under development: Not open for comment. Do not cite Under Development
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi Under development: Not open for comment. Do not cite Under Development
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi Under development: Not open for comment. Do not cite Under Development
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi Under development: Not open for comment. Do not cite Under Development
37 PPARalpha-dependent liver cancer Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes EAGMST Under Review 1.10
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Under development: Not open for comment. Do not cite Under Development 5-HTT2c kidney toxicity
104 Altered ion channel activity leading impaired heart function Kevin Dreher Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple impaired heart function Under Development 1.29
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry Under development: Not open for comment. Do not cite Under Development nitric oxide liver tumors
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for comment. Do not cite Included in OECD Work Plan AhR uroporphyria EAGMST Under Review 1.7
150 Aryl hydrocarbon receptor activation leading to embryolethality via cardiotoxicty Amani Farhat Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.7
91 Sodium channel inhibition leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan sodium channel reduced survival Under Development 1.29
93 sodium channel inhibition leading to increased predation Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan sodium channel increased predation Under Development 1.29
94 Sodium channel inhibition leading to congenital malformations Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan sodium channel congenital malformations Under Development 1.29
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan ERG reduced survival Under Development 1.29
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan sodium channel acute mortality Under Development 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan 5-HTT increased predation Under Development 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan H2 reduced survival Under Development 1.29
113 Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan GluCl Channel acute mortality Under Development 1.29
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan HMG-CoA reductase decreased fertility Under Development 1.29
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan p-amino hippuric acid renal failure and mortality Under Development 1.29
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
186 unknown MIE leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert Under development: Not open for comment. Do not cite Included in OECD Work Plan NIS neurodevelopmental outcomes Under Development 1.29
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures Ping Gong Open for comment. Do not cite Included in OECD Work Plan GABA epileptic seizures EAGMST Under Review 1.15
34 LXR activation leading to hepatic steatosis Marina Goumenou Under development: Not open for comment. Do not cite Under Development LXR liver steatosis
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh Under development: Not open for comment. Do not cite Included in OECD Work Plan 5-HTT increased predation Under Development 1.29
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for comment. Do not cite Included in OECD Work Plan PPAR starvation-like body-weight loss EAGMST Under Review 2.3
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
21 AhR activation leading to early life stage mortality Markus Hecker Open for comment. Do not cite Included in OECD Work Plan AhR embryo toxicity EAGMST Under Review 1.27
29 Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson Under development: Not open for comment. Do not cite Included in OECD Work Plan ER reproductive dysfunction Under Development 1.29
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson Under development: Not open for comment. Do not cite Included in OECD Work Plan ER altered sexual differentiation Under Development 1.29
53 ER agonism leading to reduced survival due to renal failure Tom Hutchinson Under development: Not open for comment. Do not cite Included in OECD Work Plan ER reduced survival Under Development 1.29
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.41
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek Under development: Not open for comment. Do not cite
240 DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek Under development: Not open for comment. Do not cite
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Under development: Not open for comment. Do not cite Included in OECD Work Plan case study Under Development 2.5
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Included in OECD Work Plan GR modulation of leydig cell function Under Development 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Included in OECD Work Plan estradiol modulation of leydig cell function Under Development 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter Under development: Not open for comment. Do not cite Included in OECD Work Plan proteins - undefined modulation of leydig cell function Under Development 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple modulation of leydig cell function Under Development 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter Under development: Not open for comment. Do not cite Included in OECD Work Plan modulation of leydig cell function Under Development 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter Under development: Not open for comment. Do not cite Included in OECD Work Plan GR modulation of leydig cell function Under Development 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Included in OECD Work Plan unk modulation of leydig cell function Under Development 1.29
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
155 Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
156 Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
157 Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
158 Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
159 Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Kiyoshi Kushima Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.38
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan GR increased disease susceptibility Under Development 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan metabolic stress is not MIE colony loss/failure Under Development 1.29
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan unk colony loss/failure Under Development 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear colony loss/failure Under Development 1.29
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear colony loss/failure Under Development 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan glucose oxidase colony loss/failure Under Development 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan nAChR colony loss/failure Under Development 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
181 Weather event contributes to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Brigitte Landesmann Open for citation & comment Included in OECD Work Plan TFHA/WNT Endorsed 1.1
144 Lysosomal damage leading to liver inflammation Brigitte Landesmann Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation Under Development 1.47
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws Under development: Not open for comment. Do not cite Included in OECD Work Plan GR decreased male fertitlity Under Development 1.29
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.50
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
199 ER mediated breast cancer AOP Molly M Morgan Under development: Not open for comment. Do not cite Under Development
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Under development: Not open for comment. Do not cite Under Development
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
258 Renal protein alkylation leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti Under development: Not open for comment. Do not cite Under Development tubulin? aneuploid offspring
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens Under development: Not open for comment. Do not cite
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez Under development: Not open for comment. Do not cite Under Development
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Included in OECD Work Plan cyclooxygenase reproductive dysfunction Under Development 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Included in OECD Work Plan cyclooxygenase reproductive dysfunction Under Development 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Included in OECD Work Plan cyclooxygenase reproductive dysfunction Under Development 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Included in OECD Work Plan cyclooxygenase reproductive dysfunction Under Development 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Included in OECD Work Plan cyclooxygenase reproductive dysfunction Under Development 1.29
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Included in OECD Work Plan Prolyl hydroxylase reproductive dysfunction Under Development 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Included in OECD Work Plan Unknown reproductive dysfunction Under Development 1.29
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière Under development: Not open for comment. Do not cite Under Development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière Under development: Not open for comment. Do not cite Under Development
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Under development: Not open for comment. Do not cite Under Development AR adverse effects in the male foetus
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Under development: Not open for comment. Do not cite Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen Under development: Not open for comment. Do not cite
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for comment. Do not cite Included in OECD Work Plan NIS learning and memory deficits in children EAGMST Under Review 1.28
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.31
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Under development: Not open for comment. Do not cite Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Under development: Not open for comment. Do not cite
173 Secretion of inflammatory cytokines leading to lung fibrosis Monita Sharma Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.32
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker Under development: Not open for comment. Do not cite Included in OECD Work Plan DBH reduced fecundity Under Development 1.29
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker Under development: Not open for comment. Do not cite Included in OECD Work Plan alpha Norad Receptors delayed ovulation Under Development 1.29
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
243 Alkylation of DNA in male prebiotic germ cells leading to heritable mutations Kristie Sullivan Under development: Not open for comment. Do not cite
39 Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
151 AhR signalling leading to placental vascular disruption Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired EAGMST Under Review 1.33
202 In-utero DNA topoisomerase II poisons leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
238 Excessive reactive oxygen species production leading to reproductive failure Knut Erik Tollefsen Under development: Not open for comment. Do not cite
245 Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition Knut Erik Tollefsen Under development: Not open for comment. Do not cite
4 Ecdysone receptor agonism leading to mortality Knut Erik Tollefsen Open for citation & comment Under Development EcR mortality
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
216 Excessive reactive oxygen species production leading to reproductive dysfunction Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration EAGMST Approved 1.13
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins during brain development leads to impairment of learning and memory Florianne Tschudi-Monnet Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration Under Development 1.13
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under development: Not open for comment. Do not cite Included in OECD Work Plan AChE acute mortality Under Development 1.3
23 Androgen receptor agonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction EAGMST Approved 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve Under development: Not open for comment. Do not cite Included in OECD Work Plan cyclooxygenase reproductive failure Under Development 1.29
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
211 Handbook development AOP Dan Villeneuve Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
205 AOP from chemical insult to cell death Mathieu Vinken Open for comment. Do not cite Under Development
146 Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch Under development: Not open for comment. Do not cite Included in OECD Work Plan ER Under Development 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Alpha2u adenomas and carcinomas Under Development 1.29
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan pyruvate dehydrogenase hepatocellular carcinoma Under Development 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan cytotox is not MIE bronchioloalveolar adenomas and carcinomas Under Development 1.29
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan NIS follicular cell adenomas and carcinomas Under Development 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan AR leydig cell tumors Under Development 1.29
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan dopamine?? endometrial adenocarcinomas Under Development 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan HPPD corneal papillomas and carcinomas Under Development 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan cytotox not MIE forestomach tumors Under Development 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan cytotox is not MIE renal tubular adenomas and carcinomas Under Development 1.29
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan cytotox is not MIE hepatocellular adenomas and carcinomas Under Development 1.29
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan TPO follicular cell adenomas and carcinomas Under Development 1.29
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan 5α-reductase leydig cell tumors Under Development 1.29
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear urothelial papillomas and carcinomas Under Development 1.29
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.29
212 Histone deacetylase inhibition leading to testicular toxicity Takashi Yamada Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.52
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
220 Chronic Cyp2E1 Activation Leading to Liver Cancer Carole Yauk Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.24
139 Alkylation of DNA leading to cancer 1 Carole Yauk Under development: Not open for comment. Do not cite Under Development DNA alkylation cancer
128 Kidney dysfunction by decreased thyroid hormone Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
130 Phospholipase A inhibitors lead to hepatotoxicity Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39