AOPs

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Showing 1 to 25 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
211 Handbook development AOP Dan Villeneuve BY-SA None None
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation None
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
186 unknown MIE leading to renal failure and mortality Kellie Fay BY-SA 1114: Unknown, MIE 351: Increased Mortality
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1164: Increased, Population
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay BY-SA 584: Inhibition, sodium channel None
199 ER mediated breast cancer AOP Molly M Morgan BY-SA None None
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood BY-SA None 1079: Increased, Adenomas/carcinomas (mammary)
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood BY-SA 1038: Activation, beta-2 adrenergic receptor 1044: Promotion, mesovarian leiomyomas
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood BY-SA None
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood BY-SA None 1063: Increased, Pancreatic acinar tumors
167 Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells Travis Karschnik BY-SA 111: Agonism, Estrogen receptor 1070: Increased, adenosquamous carcinomas of endometrium
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood BY-SA None 1079: Increased, Adenomas/carcinomas (mammary)
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood BY-SA None 1082: Increased, adenomas (pituitary)