3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits |
Andrea Terron |
BY-SA |
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
|
- Parkinsonian motor deficits
| WPHA/WNT Endorsed |
1.33 |
6 |
Antagonist binding to PPARα leading to body-weight loss |
Kurt A. Gust |
BY-SA |
- Binding of antagonist, PPAR alpha
|
| WPHA/WNT Endorsed |
2.3 |
10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain |
Ping Gong |
BY-SA |
- Binding at picrotoxin site, iGABAR chloride channel
|
- Occurrence, Epileptic seizure
| WPHA/WNT Endorsed |
1.15 |
12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging |
Florianne Tschudi-Monnet |
BY-SA |
- Binding of antagonist, NMDA receptors
|
- N/A, Neurodegeneration
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.13 |
13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities |
Anna Price |
BY-SA |
- Binding of antagonist, NMDA receptors
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.22 |
15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations |
Carole Yauk |
BY-SA |
|
- Increase, Heritable mutations in offspring
| WPHA/WNT Endorsed |
1.11 |
17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory |
Marie-Gabrielle Zurich |
BY-SA |
- Binding, Thiol/seleno-proteins involved in protection against oxidative stress
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.13 |
21 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 |
Markus Hecker |
BY-SA |
|
| WPHA/WNT Endorsed |
1.27 |
23 |
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) |
Dan Villeneuve |
BY-SA |
- Agonism, Androgen receptor
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
25 |
Aromatase inhibition leading to reproductive dysfunction |
Dan Villeneuve |
BY-SA |
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
38 |
Protein Alkylation leading to Liver Fibrosis |
Brigitte Landesmann |
BY-SA |
|
| WPHA/WNT Endorsed |
1.14 |
40 |
Covalent Protein binding leading to Skin Sensitisation |
Sharon Munn |
BY-SA |
- Covalent Binding, Protein
|
| WPHA/WNT Endorsed |
1.1 |
42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Cognitive Function, Decreased
| WPHA/WNT Endorsed |
1.10 |
43 |
Disruption of VEGFR Signaling Leading to Developmental Defects |
Tom Knudsen |
BY-SA |
|
- Increased, Developmental Defects
| WPHA/WNT Endorsed |
1.6 |
48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. |
Anna Price |
BY-SA |
- Binding of agonist, Ionotropic glutamate receptors
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.23 |
54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment |
Anna Price |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.28 |
131 |
Aryl hydrocarbon receptor activation leading to uroporphyria |
Amani Farhat |
BY-SA |
|
| WPHA/WNT Endorsed |
1.7 |
150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF |
Amani Farhat |
BY-SA |
|
- Increase, Early Life Stage Mortality
| WPHA/WNT Endorsed |
1.7 |
154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response |
Takumi Ohishi |
BY-SA |
- Inhibition, Calcineurin Activity
|
- Impairment, T-cell dependent antibody response
| WPHA/WNT Endorsed |
1.38 |
155 |
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
156 |
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
157 |
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
158 |
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
159 |
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
173 |
Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis |
Sabina Halappanavar |
All rights reserved |
- Substance interaction with the lung resident cell membrane components
|
| WPHA/WNT Endorsed |
1.32 |
202 |
Inhibitor binding to topoisomerase II leading to infant leukaemia |
Andrea Terron |
BY-SA |
- Binding to (interferes with) topoisomerase II enzyme
|
| WPHA/WNT Endorsed |
1.53 |
212 |
Histone deacetylase inhibition leading to testicular atrophy |
Shihori Tanabe |
BY-SA |
- Histone deacetylase inhibition
|
| WPHA/WNT Endorsed |
1.52 |
220 |
Cyp2E1 Activation Leading to Liver Cancer |
Francina Webster |
BY-SA |
|
| WPHA/WNT Endorsed |
1.24 |
263 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| WPHA/WNT Endorsed |
1.92 |
272 |
Deposition of energy leading to lung cancer |
Vinita Chauhan |
BY-SA |
|
| WPHA/WNT Endorsed |
1.56 |
277 |
Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response |
Takao Ashikaga |
BY-SA |
- Impaired IL-1R1 signaling in T cell
|
- Impairment, T-cell dependent antibody response
| WPHA/WNT Endorsed |
1.48 |
296 |
Oxidative DNA damage leading to chromosomal aberrations and mutations |
Carole Yauk |
BY-SA |
- Increase, Oxidative damage to DNA
|
- Increase, Mutations
- Increase, Chromosomal aberrations
| WPHA/WNT Endorsed |
1.76 |
346 |
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Kelvin Santana Rodriguez |
BY-SA |
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
360 |
Chitin synthase 1 inhibition leading to mortality |
Simon Schmid |
BY-SA |
- Inhibition, Chitin synthase 1
|
| WPHA/WNT Endorsed |
1.94 |
376 |
Androgen receptor agonism leading to male-biased sex ratio |
Dan Villeneuve |
BY-SA |
- Agonism, Androgen receptor
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female |
Elise Grignard |
BY-SA |
- reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
|
- impaired, Fertility
- irregularities, ovarian cycle
| EAGMST Under Review |
1.21 |
18 |
PPARα activation in utero leading to impaired fertility in males |
Elise Grignard |
BY-SA |
|
- impaired, Fertility
- Malformation, Male reproductive tract
| EAGMST Under Review |
1.21 |
30 |
Estrogen receptor antagonism leading to reproductive dysfunction |
Dan Villeneuve |
BY-SA |
- Antagonism, Estrogen receptor
|
- Decrease, Population growth rate
| EAGMST Under Review |
1.12 |
41 |
Sustained AhR Activation leading to Rodent Liver Tumours |
Rick Becker |
BY-SA |
- Activation, Long term AHR receptor driven direct and indirect gene expression changes
|
- Formation, Hepatocellular and Bile duct tumors
| EAGMST Under Review |
1.7 |
46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) |
Ted Simon |
BY-SA |
- Formation, Pro-mutagenic DNA Adducts
|
- Tumorigenesis, Hepatocellular carcinoma
| EAGMST Under Review |
1.8 |
106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring |
Francesco Marchetti |
BY-SA |
|
- Increase, Aneuploid offspring
| EAGMST Under Review |
1.11 |
107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat |
Kristin Lichti-Kaiser |
BY-SA |
- Activation, Constitutive androstane receptor
|
- Increase, hepatocellular adenomas and carcinomas
| EAGMST Under Review |
1.17 |
136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors |
Justin Teeguarden |
BY-SA |
- Decrease, Intracellular pH
|
- Increase, Site of Contact Nasal Tumors
| EAGMST Under Review |
2.7 |
144 |
Endocytic lysosomal uptake leading to liver fibrosis |
Marina Kuburic |
BY-SA |
- Endocytotic lysosomal uptake
|
| EAGMST Under Review |
1.47 |
282 |
Adverse outcome pathway on photochemical toxicity initiated by light exposure |
Satomi Onoue |
BY-SA |
- ROS generation from photoactivated chemicals
|
- Inflamatory events in light-exposed tissues
| EAGMST Under Review |
1.49 |
298 |
Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer |
Shihori Tanabe |
BY-SA |
- Increases in cellular reactive oxygen species
- Chronic reactive oxygen species
|
- Treatment-resistant gastric cancer
| EAGMST Under Review |
1.58 |
363 |
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure |
Lucia Vergauwen |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| EAGMST Under Review |
1.35 |
455 |
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development |
Prarthana Shankar |
BY-SA |
|
- Increase, Early Life Stage Mortality
- Facial cartilage structures are reduced in size and morphologically distorted
| EAGMST Under Review |
|
456 |
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity |
Prarthana Shankar |
BY-SA |
|
- Increase, Early Life Stage Mortality
| EAGMST Under Review |
|
8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Katie Paul Friedman |
Open for adoption |
- Activation, Pregnane-X receptor, NR1l2
|
| Under Development |
1.9 |
11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol |
Jun Kanno |
BY-SA |
|
| Under Development |
2.5 |
16 |
Acetylcholinesterase inhibition leading to acute mortality |
Dan Villeneuve |
BY-SA |
- Acetylcholinesterase (AchE) Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.3 |
27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Mathieu Vinken |
BY-SA |
- Inhibition, Bile Salt Export Pump (ABCB11)
|
| Under Development |
1.19 |
31 |
Oxidation of iron in hemoglobin leading to hematotoxicity |
Mitchell S. Wilbanks |
Open for adoption |
- N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
|
| Under Development |
1.16 |
35 |
Narcosis leading to respiratory failure |
Dries Knapen |
BY-SA |
- Accumulation, Biological membranes
|
| Under Development |
1.2 |
37 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Chris Corton |
BY-SA |
|
- Increase, hepatocellular adenomas and carcinomas
| Under Development |
1.17 |
39 |
Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response |
Jessica Ponder |
BY-SA |
- Covalent Binding, Protein
|
- Increase, Allergic Respiratory Hypersensitivity Response
| Under Development |
1.20 |
51 |
PPARα activation leading to impaired fertility in adult male rodents |
Elise Grignard |
BY-SA |
|
| Under Development |
1.21 |
117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Open for adoption |
- Activation, Androgen receptor
|
- Increase, hepatocellular adenomas and carcinomas
| Under Development |
1.26 |
128 |
Kidney dysfunction by decreased thyroid hormone |
Jung-Hwa Oh |
BY-SA |
- Thyroid hormone synthesis, Decreased
|
- Occurrence, Kidney toxicity
| Under Development |
1.40 |
130 |
Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity |
Jung-Hwa Oh |
BY-SA |
- Inhibition, Phospholipase A
|
- Formation, Liver fibrosis
| Under Development |
1.39 |
148 |
EGFR Activation Leading to Decreased Lung Function |
Karsta Luettich |
BY-SA |
|
| Under Development |
1.51 |
149 |
Peptide Oxidation Leading to Hypertension |
Frazer Lowe |
BY-SA |
|
| Under Development |
1.50 |
151 |
AhR activation leading to preeclampsia |
Sabrina Tait |
All rights reserved |
|
| Under Development |
1.42 |
152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity |
Kristie Sullivan |
BY-SA |
- Binding, Transthyretin in serum
|
- Cognitive Function, Decreased
| Under Development |
1.41 |
187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage |
Barnett Rattner |
BY-SA |
- Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
- Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
- Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
|
- Impaired recruitment , Population trajectory
| Under Development |
1.31 |
206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Jinhee Choi |
All rights reserved |
|
| Under Development |
1.54 |
237 |
Substance interaction with lung resident cell membrane components leading to atherosclerosis |
Ulla Vogel |
BY-SA |
- Substance interaction with the lung resident cell membrane components
|
| Under Development |
1.55 |
256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Angela Mally |
BY-SA |
- Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Angela Mally |
BY-SA |
- Binding of substrate, endocytic receptor
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
258 |
Renal protein alkylation leading to kidney toxicity |
Angela Mally |
BY-SA |
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
261 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Luigi Margiotta-Casaluci |
All rights reserved |
- Blockade, L-Type Calcium Channels
|
| Under Development |
1.45 |
262 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Luigi Margiotta-Casaluci |
All rights reserved |
|
| Under Development |
1.45 |
264 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
265 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
266 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
267 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
268 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
271 |
Inhibition of thyroid peroxidase leading to impaired fertility in fish |
June-Woo Park |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Reduction, Cumulative fecundity and spawning
| Under Development |
1.59 |
283 |
L-type calcium channel blockade leading to hypotension |
Luigi Margiotta-Casaluci |
All rights reserved |
|
| Under Development |
1.45 |
289 |
Inhibition of 5α-reductase leading to impaired fecundity in female fish |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.81 |
292 |
Inhibition of tyrosinase leads to decreased population in fish |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.78 |
293 |
Increased DNA damage leading to increased risk of breast cancer |
Jessica Helm |
BY-SA |
|
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
| Under Development |
1.80 |
294 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Jessica Helm |
BY-SA |
- Increase in reactive oxygen and nitrogen species (RONS)
|
- Increase, DNA damage
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
| Under Development |
1.80 |
295 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Andrea Hindman |
BY-SA |
|
| Under Development |
1.79 |
297 |
Inhibition of retinaldehyde dehydrogenase leads to population decline |
Young Jun Kim |
BY-SA |
- Retinaldehyde dehydrogenase inhibition
|
- Decrease, Population growth rate
| Under Development |
1.77 |
300 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
BY-SA |
- Antagonism, Thyroid Receptor
|
- Cognitive Function, Decreased
| Under Development |
1.84 |
302 |
Lung surfactant function inhibition leading to decreased lung function |
Jorid Birkelund Sørli |
BY-SA |
- Inhibition of lung surfactant function
|
| Under Development |
1.87 |
303 |
Frustrated phagocytosis-induced lung cancer |
Carole Seidel |
BY-SA |
|
| Under Development |
1.86 |
305 |
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
306 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
307 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
313 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Hiroyuki Komatsu |
BY-SA |
|
| Under Development |
1.75 |
314 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Yasuharu Otsubo |
BY-SA |
- Binding to estrogen receptor (ER)-α in immune cells
|
- Exacerbation of systemic lupus erythematosus (SLE)
| Under Development |
1.73 |
315 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Yasuhiro Yoshida |
BY-SA |
|
- Impairment of T-cell dependent antibody response
| Under Development |
1.74 |
316 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Shigeru Hisada |
BY-SA |
|
- Pancreatic acinar cell tumors
| Under Development |
1.60 |
319 |
Binding to ACE2 leading to lung fibrosis |
Young Jun Kim |
BY-SA |
- Induced dysregulation of ACE2
|
| Under Development |
1.96 |
320 |
Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality |
Young Jun Kim |
BY-SA |
|
| Under Development |
1.96 |
344 |
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
- Nipple retention (NR), increased
| Under Development |
1.108 |
345 |
Androgen receptor (AR) antagonism leading to decreased fertility in females |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
| Under Development |
1.109 |
348 |
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.93 |
349 |
Inhibition of 11β-hydroxylase leading to decresed population trajectory |
Young Jun Kim |
BY-SA |
- 11β-hydroxylase inhibition
|
- Decrease, Population growth rate
| Under Development |
1.93 |
358 |
Chitinase inhibition leading to mortality |
Simon Schmid |
All rights reserved |
|
| Under Development |
1.94 |
359 |
Chitobiase inhibition leading to mortality |
Simon Schmid |
All rights reserved |
|
| Under Development |
1.94 |
361 |
Sulfonylureareceptor binding leading to mortality |
Simon Schmid |
All rights reserved |
- Increase, Sulfonylurea receptor binding
|
| Under Development |
1.94 |
364 |
Thyroperoxidase inhibition leading to altered visual function via decreased eye size |
Lucia Vergauwen |
All rights reserved |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.35 |
365 |
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning |
Lucia Vergauwen |
All rights reserved |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.35 |
374 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Anna Price |
All rights reserved |
|
| Under Development |
1.96 |
379 |
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation |
Shihori Tanabe |
All rights reserved |
|
- Thrombosis and Disseminated Intravascular Coagulation
| Under Development |
1.96 |
381 |
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Young Jun Kim |
BY-SA |
|
| Under Development |
1.96 |
382 |
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Young Jun Kim |
BY-SA |
- Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
|
| Under Development |
1.96 |
383 |
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Young Jun Kim |
BY-SA |
- Induced dysregulation of ACE2
|
| Under Development |
1.96 |
392 |
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation |
Penny Nymark |
BY-SA |
- Fibrinolysis, decreased
- Bradykinin system, hyperactivated
|
| Under Development |
1.96 |
394 |
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) |
Sandra Coecke |
BY-SA |
|
- impaired olfactory function (anosmia)
| Under Development |
1.96 |
395 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) |
Magda Sachana |
BY-SA |
|
- Cerebrovascular disease (stroke)
| Under Development |
1.96 |
397 |
Bulky DNA adducts leading to mutations |
Carole Yauk |
BY-SA |
- Bulky DNA adducts, increase
|
| Under Development |
1.11 |
398 |
Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary |
Terje Svingen |
BY-SA |
- Inhibition of ALDH1A (RALDH)
|
| Under Development |
1.97 |
412 |
Endothelial cell dysfunction leading to thromboinflammation |
Luigi Margiotta-Casaluci |
All rights reserved |
|
- Thromboinflammation, Increased
| Under Development |
1.96 |
422 |
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption |
Laure-Alix Clerbaux |
BY-SA |
|
| Under Development |
1.96 |
428 |
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis |
Laure-Alix Clerbaux |
BY-SA |
|
| Under Development |
1.96 |
430 |
Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation |
Sally Mayasich |
All rights reserved |
|
- Viral infection and host-to-host transmission, proliferated
| Under Development |
1.96 |
437 |
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity |
Baki Sadi |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Occurrence, Kidney toxicity
| Under Development |
1.99 |
439 |
Activation of the AhR leading to metastatic breast cancer |
Louise Benoit |
BY-SA |
|
| Under Development |
1.105 |
440 |
Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia |
Kalyan Gayen |
All rights reserved |
- Suppression, Estrogen receptor (ER) activity
|
- Promotion, ovarian adenomas
- Promotion, Ovarian Cancer
| Under Development |
1.104 |
442 |
Binding to voltage gate sodium channels during development leads to cognitive impairment |
Iris Mangas |
BY-SA |
- Binding to voltage-gated sodium channel
|
- Impairment, Learning and memory
| Under Development |
1.91 |
443 |
DNA damage and mutations leading to Metastatic Breast Cancer |
Usha Adiga |
BY-SA |
- Increased, DNA damage and mutation
|
| Under Development |
1.103 |
460 |
Antagonism of Smoothened receptor leading to orofacial clefting |
Jacob Reynolds |
All rights reserved |
- Antagonism, Smoothened receptor
|
| Under Development |
1.101 |
474 |
Succinate dehydrogenase inactivation leading to cancer |
Sylvie Bortoli |
BY-SA |
|
| Under Development |
1.106 |
475 |
Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons |
Shihori Tanabe |
All rights reserved |
- Binding of agonist, Ionotropic glutamate receptors
|
- Impairment, Learning and memory
| Under Development |
1.107 |
479 |
Mitochondrial complexes inhibition leading to heart failure via increased myocardial oxidative stress |
Sivakumar Murugadoss |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Heart failure
- Increase, Mortality
| Under Development |
1.102 |
480 |
Mitochondrial complexes inhibition leading to heart failure via decreased ATP production |
Alexandra Schaffert |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Heart failure
- Increase, Mortality
| Under Development |
1.102 |
491 |
Decrease, GLI1/2 target gene expression leads to orofacial clefting |
Jacob Reynolds |
All rights reserved |
- Decrease, GLI1/2 target gene expression
|
| Under Development |
1.101 |
502 |
Decrease, cholesterol synthesis leads to orofacial clefting |
Jacob Reynolds |
All rights reserved |
|
| Under Development |
1.101 |