AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Brigitte Landesmann Open for citation & comment Included in OECD Work Plan TFHA/WNT Endorsed 1.1
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired EAGMST Approved 1.33
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration EAGMST Approved 1.13
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction EAGMST Approved 1.12
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes EAGMST Approved 1.10
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for comment. Do not cite Included in OECD Work Plan PPAR starvation-like body-weight loss EAGMST Under Review 2.3
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong Open for comment. Do not cite Included in OECD Work Plan GABA epileptic seizures EAGMST Under Review 1.15
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
21 aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker Open for comment. Do not cite Included in OECD Work Plan AhR embryo toxicity EAGMST Under Review 1.27
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for comment. Do not cite Included in OECD Work Plan NIS learning and memory deficits in children EAGMST Under Review 1.28
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Richard C. Peffer, Ph.D., DABT Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.18
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for comment. Do not cite Included in OECD Work Plan AhR uroporphyria EAGMST Under Review 1.7
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.7
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Kiyoshi Kushima Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.38
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
220 Cyp2E1 Activation Leading to Liver Cancer Carole Yauk Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.24
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Under development: Not open for comment. Do not cite Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Under development: Not open for comment. Do not cite Included in OECD Work Plan case study Under Development 2.5
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under development: Not open for comment. Do not cite Included in OECD Work Plan AChE acute mortality Under Development 1.3
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration Under Development 1.13
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Under development: Not open for comment. Do not cite Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
37 PPARalpha-dependent liver cancer Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
39 Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
128 Kidney dysfunction by decreased thyroid hormone Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
130 Phospholipase A inhibitors lead to hepatotoxicity Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation Under Development 1.47
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.50
151 AhR signalling leading to placental vascular disruption Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.41
155 Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
156 Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
157 Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
158 Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
159 Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
173 Increased substance interaction with the resident cell membrane components leading to lung fibrosis Sabina Halappanavar Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.32
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.31
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.54
212 Histone deacetylase inhibition leading to testicular toxicity Takashi Yamada Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.52