AOPs

ID Title Point of Contact License MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA
  • Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
  • Parkinsonian motor deficits
WPHA/WNT Endorsed 1.33
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust BY-SA
  • Binding of antagonist, PPAR alpha
  • Decreased, Body Weight
WPHA/WNT Endorsed 2.3
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong BY-SA
  • Binding at picrotoxin site, iGABAR chloride channel
  • Occurrence, Epileptic seizure
WPHA/WNT Endorsed 1.15
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet BY-SA
  • Binding of antagonist, NMDA receptors
  • N/A, Neurodegeneration
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA
  • Binding of antagonist, NMDA receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk BY-SA
  • Alkylation, DNA
  • Increase, Heritable mutations in offspring
WPHA/WNT Endorsed 1.11
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA
  • Binding, Thiol/seleno-proteins involved in protection against oxidative stress
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.13
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker BY-SA
  • Activation, AhR
WPHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve BY-SA
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve BY-SA
  • Inhibition, Aromatase
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann BY-SA
  • Alkylation, Protein
  • N/A, Liver fibrosis
WPHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Sharon Munn BY-SA
  • Covalent Binding, Protein
  • sensitisation, skin
WPHA/WNT Endorsed 1.1
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA
  • Thyroperoxidase, Inhibition
  • Cognitive Function, Decreased
WPHA/WNT Endorsed 1.10
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen BY-SA
  • Inhibition, VegfR2
  • Increased, Developmental Defects
WPHA/WNT Endorsed 1.6
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price BY-SA
  • Binding of agonist, Ionotropic glutamate receptors
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.23
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price BY-SA
  • Inhibition, Na+/I- symporter (NIS)
  • Impairment, Learning and memory
WPHA/WNT Endorsed 1.28
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA
  • Activation, AhR
  • Uroporphyria
WPHA/WNT Endorsed 1.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA
  • Activation, AhR
  • Increase, Early Life Stage Mortality
WPHA/WNT Endorsed 1.7
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi BY-SA
  • Inhibition, Calcineurin Activity
  • Impairment, T-cell dependent antibody response
WPHA/WNT Endorsed 1.38
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 2
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA
  • Inhibition, Deiodinase 1
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.35
173 Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis Sabina Halappanavar All rights reserved
  • Substance interaction with the lung resident cell membrane components
  • Pulmonary fibrosis
WPHA/WNT Endorsed 1.32
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron BY-SA
  • Binding to (interferes with) topoisomerase II enzyme
  • Infant leukaemia
WPHA/WNT Endorsed 1.53
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe BY-SA
  • Histone deacetylase inhibition
  • Testicular atrophy
WPHA/WNT Endorsed 1.52
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA
  • Activation of Cyp2E1
  • Liver Cancer
WPHA/WNT Endorsed 1.24
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
WPHA/WNT Endorsed 1.92
272 Deposition of energy leading to lung cancer Vinita Chauhan BY-SA
  • Deposition of Energy
  • Increase, lung cancer
WPHA/WNT Endorsed 1.56
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga BY-SA
  • Impaired IL-1R1 signaling in T cell
  • Impairment, T-cell dependent antibody response
WPHA/WNT Endorsed 1.48
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA
  • Increase, Oxidative damage to DNA
  • Increase, Mutations
  • Increase, Chromosomal aberrations
WPHA/WNT Endorsed 1.76
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez BY-SA
  • Inhibition, Aromatase
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid BY-SA
  • Inhibition, Chitin synthase 1
  • Increase, Mortality
WPHA/WNT Endorsed 1.94
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve BY-SA
  • Agonism, Androgen receptor
  • Decrease, Population growth rate
WPHA/WNT Endorsed 1.12
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard BY-SA
  • reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
  • impaired, Fertility
  • irregularities, ovarian cycle
EAGMST Under Review 1.21
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard BY-SA
  • Activation, PPARα
  • impaired, Fertility
  • Malformation, Male reproductive tract
EAGMST Under Review 1.21
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve BY-SA
  • Antagonism, Estrogen receptor
  • Decrease, Population growth rate
EAGMST Under Review 1.12
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker BY-SA
  • Activation, Long term AHR receptor driven direct and indirect gene expression changes
  • Formation, Hepatocellular and Bile duct tumors
EAGMST Under Review 1.7
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA
  • Formation, Pro-mutagenic DNA Adducts
  • Tumorigenesis, Hepatocellular carcinoma
EAGMST Under Review 1.8
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti BY-SA
  • Binding, Tubulin
  • Increase, Aneuploid offspring
EAGMST Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA
  • Activation, Constitutive androstane receptor
  • Increase, hepatocellular adenomas and carcinomas
EAGMST Under Review 1.17
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden BY-SA
  • Decrease, Intracellular pH
  • Increase, Site of Contact Nasal Tumors
EAGMST Under Review 2.7
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA
  • Endocytotic lysosomal uptake
  • N/A, Liver fibrosis
EAGMST Under Review 1.47
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA
  • ROS generation from photoactivated chemicals
  • Inflamatory events in light-exposed tissues
EAGMST Under Review 1.49
298 Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA
  • Increases in cellular reactive oxygen species
  • Chronic reactive oxygen species
  • Treatment-resistant gastric cancer
EAGMST Under Review 1.58
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen BY-SA
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
EAGMST Under Review 1.35
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA
  • Activation, AhR
  • Increase, Early Life Stage Mortality
  • Facial cartilage structures are reduced in size and morphologically distorted
EAGMST Under Review
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Prarthana Shankar BY-SA
  • Activation, AhR
  • Increase, Early Life Stage Mortality
EAGMST Under Review
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption
  • Activation, Pregnane-X receptor, NR1l2
  • Loss, Cochlear function
Under Development 1.9
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno BY-SA
  • Activation, PXR/SXR
Under Development 2.5
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve BY-SA
  • Acetylcholinesterase (AchE) Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.3
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken BY-SA
  • Inhibition, Bile Salt Export Pump (ABCB11)
  • Cholestasis, Pathology
Under Development 1.19
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Open for adoption
  • N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
  • N/A, Cyanosis occurs
Under Development 1.16
35 Narcosis leading to respiratory failure Dries Knapen BY-SA
  • Accumulation, Biological membranes
Under Development 1.2
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA
  • Activation, PPARα
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.17
39 Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response Jessica Ponder BY-SA
  • Covalent Binding, Protein
  • Increase, Allergic Respiratory Hypersensitivity Response
Under Development 1.20
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard BY-SA
  • Activation, PPARα
  • impaired, Fertility
Under Development 1.21
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption
  • Activation, Androgen receptor
  • Increase, hepatocellular adenomas and carcinomas
Under Development 1.26
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh BY-SA
  • Thyroid hormone synthesis, Decreased
  • Occurrence, Kidney toxicity
Under Development 1.40
130 Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity Jung-Hwa Oh BY-SA
  • Inhibition, Phospholipase A
  • Formation, Liver fibrosis
Under Development 1.39
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich BY-SA
  • Activation, EGFR
  • Decrease, Lung function
Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA
  • Peptide Oxidation
  • Hypertension
Under Development 1.50
151 AhR activation leading to preeclampsia Sabrina Tait All rights reserved
  • Activation, AhR
  • increase, Preeclampsia
Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan BY-SA
  • Binding, Transthyretin in serum
  • Cognitive Function, Decreased
Under Development 1.41
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner BY-SA
  • Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
  • Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
  • Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
  • Impaired recruitment , Population trajectory
Under Development 1.31
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi All rights reserved
  • Inactivation of PPARγ
  • Lung fibrosis
Under Development 1.54
237 Substance interaction with lung resident cell membrane components leading to atherosclerosis Ulla Vogel BY-SA
  • Substance interaction with the lung resident cell membrane components
  • Atherosclerosis
Under Development 1.55
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally BY-SA
  • Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
  • Occurrence, Kidney toxicity
Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally BY-SA
  • Binding of substrate, endocytic receptor
  • Occurrence, Kidney toxicity
Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Angela Mally BY-SA
  • Alkylation, Protein
  • Occurrence, Kidney toxicity
Under Development 1.43
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci All rights reserved
  • Blockade, L-Type Calcium Channels
  • Heart failure
Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci All rights reserved
Under Development 1.45
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA
  • Decrease, Coupling of oxidative phosphorylation
  • Decrease, Growth
Under Development 1.92
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park BY-SA
  • Thyroperoxidase, Inhibition
  • Reduction, Cumulative fecundity and spawning
Under Development 1.59
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci All rights reserved
Under Development 1.45
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim BY-SA
  • Inhibition, 5α-reductase
  • Decrease, Population growth rate
Under Development 1.81
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim BY-SA
  • Inhibition of tyrosinase
  • Decrease, Population growth rate
Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA
  • Increase in reactive oxygen and nitrogen species (RONS)
  • Increase, DNA damage
  • Increase, Mutations
  • Increased, Ductal Hyperplasia
  • N/A, Breast Cancer
Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA
Under Development 1.79
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim BY-SA
  • Retinaldehyde dehydrogenase inhibition
  • Decrease, Population growth rate
Under Development 1.77
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA
  • Antagonism, Thyroid Receptor
  • Cognitive Function, Decreased
Under Development 1.84
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA
  • Inhibition of lung surfactant function
  • Decrease, Lung function
Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA
  • Frustrated phagocytosis
  • Lung cancer
Under Development 1.86
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA
  • Inhibition, 5α-reductase
  • anogenital distance (AGD), decreased
Under Development 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA
  • Antagonism, Androgen receptor
  • anogenital distance (AGD), decreased
Under Development 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA
  • anogenital distance (AGD), decreased
Under Development 1.90
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu BY-SA
  • Stimulation, TLR7/8
  • Psoriatic skin disease
Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA
  • Binding to estrogen receptor (ER)-α in immune cells
  • Exacerbation of systemic lupus erythematosus (SLE)
Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA
  • Inhibition of JAK3
  • Impairment of T-cell dependent antibody response
Under Development 1.74
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA
  • Trypsin inhibition
  • Pancreatic acinar cell tumors
Under Development 1.60
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA
  • Induced dysregulation of ACE2
  • Lung fibrosis
Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA
  • Binding to ACE2
  • Increased Mortality
Under Development 1.96
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA
  • Antagonism, Androgen receptor
  • Nipple retention (NR), increased
Under Development 1.108
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA
  • Antagonism, Androgen receptor
  • impaired, Fertility
Under Development 1.109
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim BY-SA
  • Inhibition of 11β-HSD
  • Decrease, Population growth rate
Under Development 1.93
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim BY-SA
  • 11β-hydroxylase inhibition
  • Decrease, Population growth rate
Under Development 1.93
358 Chitinase inhibition leading to mortality Simon Schmid All rights reserved
  • Inhibition, Chitinase
  • Increase, Mortality
Under Development 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid All rights reserved
  • Inhibition, Chitobiase
  • Increase, Mortality
Under Development 1.94
361 Sulfonylureareceptor binding leading to mortality Simon Schmid All rights reserved
  • Increase, Sulfonylurea receptor binding
  • Increase, Mortality
Under Development 1.94
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.35
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen All rights reserved
  • Thyroperoxidase, Inhibition
  • Increased Mortality
  • Decrease, Population growth rate
Under Development 1.35
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price All rights reserved
  • Binding to ACE2
  • Encephalitis
Under Development 1.96
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved
  • Binding to ACE2
  • Thrombosis and Disseminated Intravascular Coagulation
Under Development 1.96
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim BY-SA
  • Binding to ACE2
  • dysgeusia
Under Development 1.96
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim BY-SA
  • Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
  • Lung fibrosis
Under Development 1.96
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim BY-SA
  • Induced dysregulation of ACE2
  • N/A, Liver fibrosis
Under Development 1.96
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark BY-SA
  • Fibrinolysis, decreased
  • Bradykinin system, hyperactivated
  • Hyperinflammation
Under Development 1.96
394 SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) Sandra Coecke BY-SA
  • Binding to ACE2
  • impaired olfactory function (anosmia)
Under Development 1.96
395 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) Magda Sachana BY-SA
  • Binding to ACE2
  • Cerebrovascular disease (stroke)
Under Development 1.96
397 Bulky DNA adducts leading to mutations Carole Yauk BY-SA
  • Bulky DNA adducts, increase
  • Increase, Mutations
Under Development 1.11
398 Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary Terje Svingen BY-SA
  • Inhibition of ALDH1A (RALDH)
  • impaired, Fertility
Under Development 1.97
412 Endothelial cell dysfunction leading to thromboinflammation Luigi Margiotta-Casaluci All rights reserved
  • Thromboinflammation, Increased
Under Development 1.96
422 Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA
  • Binding to ACE2
Under Development 1.96
428 Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis Laure-Alix Clerbaux BY-SA
  • Binding to ACE2
Under Development 1.96
430 Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation Sally Mayasich All rights reserved
  • Binding to ACE2
  • Viral infection and host-to-host transmission, proliferated
Under Development 1.96
437 Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity Baki Sadi BY-SA
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Occurrence, Kidney toxicity
Under Development 1.99
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA
  • Activation, AhR
  • metastatic breast cancer
Under Development 1.105
440 Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia Kalyan Gayen All rights reserved
  • Suppression, Estrogen receptor (ER) activity
  • Promotion, ovarian adenomas
  • Promotion, Ovarian Cancer
Under Development 1.104
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA
  • Binding to voltage-gated sodium channel
  • Impairment, Learning and memory
Under Development 1.91
443 DNA damage and mutations leading to Metastatic Breast Cancer Usha Adiga BY-SA
  • Increased, DNA damage and mutation
  • metastatic breast cancer
Under Development 1.103
460 Antagonism of Smoothened receptor leading to orofacial clefting Jacob Reynolds All rights reserved
  • Antagonism, Smoothened receptor
  • Orofacial clefting
Under Development 1.101
474 Succinate dehydrogenase inactivation leading to cancer Sylvie Bortoli BY-SA
Under Development 1.106
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved
  • Binding of agonist, Ionotropic glutamate receptors
  • Impairment, Learning and memory
Under Development 1.107
479 Mitochondrial complexes inhibition leading to heart failure via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Heart failure
  • Increase, Mortality
Under Development 1.102
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA
  • Inhibition, Mitochondrial Electron Transport Chain Complexes
  • Heart failure
  • Increase, Mortality
Under Development 1.102
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds All rights reserved
  • Decrease, GLI1/2 target gene expression
  • Orofacial clefting
Under Development 1.101
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds All rights reserved
  • Orofacial clefting
Under Development 1.101