3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits |
Andrea Terron |
Open for citation & comment |
Included in OECD Work Plan |
888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) |
896: Parkinsonian motor deficits |
WPHA/WNT Endorsed |
1.33 |
6 |
Antagonist binding to PPARα leading to body-weight loss |
Kurt A. Gust |
Open for citation & comment |
Included in OECD Work Plan |
998: Binding of antagonist, PPAR alpha |
864: Decreased, Body Weight |
WPHA/WNT Endorsed |
2.3 |
10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain |
Ping Gong |
Open for citation & comment |
Included in OECD Work Plan |
667: Binding at picrotoxin site, iGABAR chloride channel |
613: Occurrence, Epileptic seizure |
WPHA/WNT Endorsed |
1.15 |
12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging |
Florianne Tschudi-Monnet |
Open for citation & comment |
Included in OECD Work Plan |
201: Binding of antagonist, NMDA receptors |
352: N/A, Neurodegeneration and 341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.13 |
13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
201: Binding of antagonist, NMDA receptors |
341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.22 |
15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations |
Carole Yauk |
Open for citation & comment |
Included in OECD Work Plan |
97: Alkylation, DNA |
336: Increase, Heritable mutations in offspring |
WPHA/WNT Endorsed |
1.11 |
21 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 |
Markus Hecker |
Open for citation & comment |
Included in OECD Work Plan |
18: Activation, AhR |
947: Increase, early life stage mortality |
WPHA/WNT Endorsed |
1.27 |
23 |
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
25: Agonism, Androgen receptor |
360: Decrease, Population trajectory |
WPHA/WNT Endorsed |
1.12 |
25 |
Aromatase inhibition leading to reproductive dysfunction |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
36: Inhibition, Aromatase |
360: Decrease, Population trajectory |
WPHA/WNT Endorsed |
1.12 |
38 |
Protein Alkylation leading to Liver Fibrosis |
Brigitte Landesmann |
Open for citation & comment |
Included in OECD Work Plan |
244: Alkylation, Protein |
344: N/A, Liver fibrosis |
WPHA/WNT Endorsed |
1.14 |
40 |
Covalent Protein binding leading to Skin Sensitisation |
Sharon Munn |
Open for citation & comment |
Included in OECD Work Plan |
396: Covalent Binding, Protein |
827: sensitisation, skin |
WPHA/WNT Endorsed |
1.1 |
42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
Open for citation & comment |
Included in OECD Work Plan |
279: Thyroperoxidase, Inhibition |
402: Cognitive Function, Decreased |
WPHA/WNT Endorsed |
1.10 |
48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
875: Binding of agonist, Ionotropic glutamate receptors |
341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.23 |
54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
424: Inhibition, Na+/I- symporter (NIS) |
341: Impairment, Learning and memory |
WPHA/WNT Endorsed |
1.28 |
131 |
Aryl hydrocarbon receptor activation leading to uroporphyria |
Amani Farhat |
Open for citation & comment |
Included in OECD Work Plan |
18: Activation, AhR |
369: Uroporphyria |
WPHA/WNT Endorsed |
1.7 |
150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF |
Amani Farhat |
Open for citation & comment |
Included in OECD Work Plan |
18: Activation, AhR |
947: Increase, Early Life Stage Mortality |
WPHA/WNT Endorsed |
1.7 |
154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response |
Takumi Ohishi |
Open for comment. Do not cite |
Included in OECD Work Plan |
980: Inhibition, Calcineurin Activity |
984: Impairment, T-cell dependent antibody response |
WPHA/WNT Endorsed |
1.38 |
212 |
Histone deacetylase inhibition leading to testicular atrophy |
Shihori Tanabe |
Open for citation & comment |
Included in OECD Work Plan |
1502: Histone deacetylase inhibition |
1506: Testicular atrophy |
WPHA/WNT Endorsed |
1.52 |
220 |
Cyp2E1 Activation Leading to Liver Cancer |
Francina Webster |
Open for citation & comment |
Included in OECD Work Plan |
1391: Activation of Cyp2E1 |
1395: Liver Cancer |
WPHA/WNT Endorsed |
1.24 |
263 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation |
You Song |
Open for citation & comment |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
WPHA/WNT Endorsed |
1.92 |
360 |
Chitin synthase 1 inhibition leading to mortality |
Simon Schmid |
Open for citation & comment |
Included in OECD Work Plan |
1522: Inhibition, Chitin synthase 1 |
350: Increase, Mortality |
WPHA/WNT Endorsed |
1.94 |
17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory |
Marie-Gabrielle Zurich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress |
341: Impairment, Learning and memory |
EAGMST Approved |
1.13 |
155 |
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1002: Inhibition, Deiodinase 2 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
156 |
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1002: Inhibition, Deiodinase 2 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
157 |
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1009: Inhibition, Deiodinase 1 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
158 |
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1009: Inhibition, Deiodinase 1 |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
159 |
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
279: Thyroperoxidase, Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
EAGMST Approved |
1.35 |
202 |
Inhibitor binding to topoisomerase II leading to infant leukaemia |
Andrea Terron |
Open for comment. Do not cite |
Included in OECD Work Plan |
1252: Binding to (interferes with) topoisomerase II enzyme |
1254: Infant leukaemia |
EAGMST Approved |
1.53 |
272 |
Deposition of energy leading to lung cancer |
Vinita Chauhan |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1686: Direct Deposition of Energy |
1556: Increase, lung cancer |
EAGMST Approved |
1.56 |
296 |
Oxidative DNA damage leading to chromosomal aberrations and mutations |
Carole Yauk |
Open for comment. Do not cite |
Included in OECD Work Plan |
1634: Increase, Oxidative damage to DNA |
185: Increase, Mutations and 1636: Increase, Chromosomal aberrations |
EAGMST Approved |
1.76 |
7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female |
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1) |
406: impaired, Fertility and 405: irregularities, ovarian cycle |
EAGMST Under Review |
1.21 |
18 |
PPARα activation in utero leading to impaired fertility in males |
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
227: Activation, PPARα |
406: impaired, Fertility and 348: Malformation, Male reproductive tract |
EAGMST Under Review |
1.21 |
30 |
Estrogen receptor antagonism leading to reproductive dysfunction |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
112: Antagonism, Estrogen receptor |
360: Decrease, Population trajectory |
EAGMST Under Review |
1.12 |
41 |
Sustained AhR Activation leading to Rodent Liver Tumours |
Rick Becker |
Open for citation & comment |
Included in OECD Work Plan |
165: Activation, Long term AHR receptor driven direct and indirect gene expression changes |
856: Formation, Hepatocellular and Bile duct tumors |
EAGMST Under Review |
1.7 |
43 |
Disruption of VEGFR Signaling Leading to Developmental Defects |
Tom Knudsen |
Open for citation & comment |
Included in OECD Work Plan |
305: Inhibition, VegfR2 |
1001: Increased, Developmental Defects |
EAGMST Under Review |
1.6 |
46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) |
Ted Simon |
Open for citation & comment |
Included in OECD Work Plan |
373: Formation, Pro-mutagenic DNA Adducts |
378: Tumorigenesis, Hepatocellular carcinoma |
EAGMST Under Review |
1.8 |
106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring |
Francesco Marchetti |
Open for citation & comment |
Included in OECD Work Plan |
718: Binding, Tubulin |
728: Increase, Aneuploid offspring |
EAGMST Under Review |
1.11 |
107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat |
Kristin Lichti-Kaiser |
Open for citation & comment |
Included in OECD Work Plan |
715: Activation, Constitutive androstane receptor |
719: Increase, hepatocellular adenomas and carcinomas |
EAGMST Under Review |
1.17 |
136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors |
Justin Teeguarden |
Open for citation & comment |
Included in OECD Work Plan |
867: Decrease, Intracellular pH |
872: Increase, Site of Contact Nasal Tumors |
EAGMST Under Review |
2.7 |
144 |
Endocytic lysosomal uptake leading to liver fibrosis |
Marina Kuburic |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1539: Endocytotic lysosomal uptake |
344: N/A, Liver fibrosis |
EAGMST Under Review |
1.47 |
173 |
Substance interaction with the lung resident cell membrane components leading to lung fibrosis |
Sabina Halappanavar |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1495: Interaction with the lung resident cell membrane components |
1458: Pulmonary fibrosis |
EAGMST Under Review |
1.32 |
277 |
Impaired IL-1R1 signaling leading to increased susceptibility to infection |
Yutaka Kimura |
Open for citation & comment |
Included in OECD Work Plan |
1700: Impaired IL-1R1 signaling |
986: Increase, Increased susceptibility to infection |
EAGMST Under Review |
1.48 |
282 |
Adverse outcome pathway on photochemical toxicity initiated by light exposure |
Satomi Onoue |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1592: ROS generation from photoactivated chemicals |
1599: Inflamatory events in light-exposed tissues |
EAGMST Under Review |
1.49 |
298 |
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer |
Shihori Tanabe |
Open for comment. Do not cite |
Included in OECD Work Plan |
1753: Chronic reactive oxygen species |
1651: Treatment-resistant gastric cancer |
EAGMST Under Review |
1.58 |
8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Katie Paul Friedman |
Open for adoption |
Included in OECD Work Plan |
239: Activation, Pregnane-X receptor, NR1l2 |
319: Loss, Cochlear function |
Under Development |
1.9 |
11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol |
Jun Kanno |
Not under active development |
Included in OECD Work Plan |
245: Activation, PXR/SXR |
|
Under Development |
2.5 |
16 |
Acetylcholinesterase inhibition leading to acute mortality |
Dan Villeneuve |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
12: Acetylcholinesterase (AchE) Inhibition |
351: Increased Mortality and 360: Decrease, Population trajectory |
Under Development |
1.3 |
27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Mathieu Vinken |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
41: Inhibition, Bile Salt Export Pump (ABCB11) |
357: Cholestasis, Pathology |
Under Development |
1.19 |
31 |
Oxidation of iron in hemoglobin leading to hematotoxicity |
Mitchell S. Wilbanks |
Open for adoption |
Included in OECD Work Plan |
213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) |
321: N/A, Cyanosis occurs |
Under Development |
1.16 |
35 |
Narcosis leading to respiratory failure |
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
46: Accumulation, Biological membranes |
|
Under Development |
1.2 |
37 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Chris Corton |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
227: Activation, PPARα |
719: Increase, hepatocellular adenomas and carcinomas |
Under Development |
1.17 |
39 |
Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract |
Kristie Sullivan |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
396: Covalent Binding, Protein |
313: Increase, Allergic Respiratory Hypersensitivity Response |
Under Development |
1.20 |
51 |
PPARα activation leading to impaired fertility in adult male rodents |
Elise Grignard |
Not under active development |
Included in OECD Work Plan |
227: Activation, PPARα |
406: impaired, Fertility |
Under Development |
1.21 |
117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Open for adoption |
Included in OECD Work Plan |
785: Activation, Androgen receptor |
719: Increase, hepatocellular adenomas and carcinomas |
Under Development |
1.26 |
128 |
Kidney dysfunction by decreased thyroid hormone |
Jung-Hwa Oh |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
277: Thyroid hormone synthesis, Decreased |
814: Occurrence, Kidney toxicity |
Under Development |
1.40 |
130 |
Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity |
Jung-Hwa Oh |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
828: Inhibition, Phospholipase A |
840: Formation, Liver fibrosis |
Under Development |
1.39 |
148 |
EGFR Activation Leading to Decreased Lung Function |
Karsta Luettich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
941: Activation, EGFR |
1250: Decrease, Lung function |
Under Development |
1.51 |
149 |
Peptide Oxidation Leading to Hypertension |
Frazer Lowe |
Not under active development |
Included in OECD Work Plan |
209: Peptide Oxidation |
952: Hypertension |
Under Development |
1.50 |
151 |
AhR activation leading to preeclampsia |
Sabrina Tait |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
18: Activation, AhR |
1893: increase, Preeclampsia |
Under Development |
1.42 |
152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity |
Kristie Sullivan |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
957: Binding, Transthyretin in serum |
402: Cognitive Function, Decreased |
Under Development |
1.41 |
187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage |
Barnett Rattner |
Not under active development |
Included in OECD Work Plan |
1134: Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone and 1138: Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP and 1169: |
1136: Impaired recruitment , Population trajectory |
Under Development |
1.31 |
206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1270: Inactivation of PPARγ |
1276: Lung fibrosis |
Under Development |
1.54 |
237 |
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression |
Sarah Søs Poulsen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1437: Sensing of the stressor by pulmonary cells |
1443: Plaque progression in arteries |
Under Development |
1.55 |
256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Angela Mally |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1481: Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) |
814: Occurrence, Kidney toxicity |
Under Development |
1.43 |
257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Angela Mally |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1486: Binding of substrate, endocytic receptor |
814: Occurrence, Kidney toxicity |
Under Development |
1.43 |
258 |
Renal protein alkylation leading to kidney toxicity |
Angela Mally |
Not under active development |
Included in OECD Work Plan |
244: Alkylation, Protein |
814: Occurrence, Kidney toxicity |
Under Development |
1.43 |
261 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1529: Blockade, L-Type Calcium Channels |
1535: Heart failure |
Under Development |
1.45 |
262 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
264 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cell death |
You Song |
Open for citation & comment |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
265 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased lipid storage |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
266 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via oxidative DNA damage |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
267 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased lipid peroxidation |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
268 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased protein oxidation |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1446: Decrease, Coupling of oxidative phosphorylation |
1521: Decrease, Growth |
Under Development |
1.92 |
271 |
Inhibition of thyroid peroxidase leading to impaired fertility in fish |
June-Woo Park |
Open for comment. Do not cite |
Included in OECD Work Plan |
279: Thyroperoxidase, Inhibition |
78: Reduction, Cumulative fecundity and spawning |
Under Development |
1.59 |
283 |
L-type calcium channel blockade leading to hypotension |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
289 |
Inhibition of 5α-reductase leading to impaired fecundity in female fish |
Young Jun Kim |
Open for citation & comment |
Included in OECD Work Plan |
1617: 5α-reductase, inhibition |
360: Decrease, Population trajectory |
Under Development |
1.81 |
292 |
Inhibition of tyrosinase leads to decreased population in fish |
Young Jun Kim |
Open for citation & comment |
Included in OECD Work Plan |
1627: Inhibition of tyrosinase |
360: Decrease, Population trajectory |
Under Development |
1.78 |
293 |
Increased DNA damage leading to increased risk of breast cancer |
Jessica Helm |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1194: Increase, DNA damage |
185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer |
Under Development |
1.80 |
294 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Jessica Helm |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1632: Increase in reactive oxygen and nitrogen species (RONS) |
1194: Increase, DNA damage and 185: Increase, Mutations and 1192: Increased, Ductal Hyperplasia and 1193: N/A, Breast Cancer |
Under Development |
1.80 |
295 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Andrea Hindman |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.79 |
297 |
Inhibition of retinaldehyde dehydrogenase leads to population decline |
Young Jun Kim |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
1637: Retinaldehyde dehydrogenase inhibition |
360: Decrease, Population trajectory |
Under Development |
1.77 |
300 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1656: Antagonism, Thyroid Receptor |
402: Cognitive Function, Decreased |
Under Development |
1.84 |
302 |
Lung surfactant function inhibition leading to decreased lung function |
Jorid Birkelund Sørli |
Open for comment. Do not cite |
Included in OECD Work Plan |
1672: Inhibition of lung surfactant function |
1250: Decrease, Lung function |
Under Development |
1.87 |
303 |
Frustrated phagocytosis-induced lung cancer |
Carole Seidel |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1668: Frustrated phagoytosis |
1670: Lung cancer |
Under Development |
1.86 |
305 |
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1617: 5α-reductase, inhibition |
1688: decrease, male anogenital distance |
Under Development |
1.90 |
306 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
26: Antagonism, Androgen receptor |
1688: decrease, male anogenital distance |
Under Development |
1.90 |
307 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
1688: decrease, male anogenital distance |
Under Development |
1.90 |
313 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Hiroyuki Komatsu |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1706: Stimulation, TLR7/8 |
1709: Psoriatic skin disease |
Under Development |
1.75 |
314 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Yasuharu Otsubo |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1710: Binding to estrogen receptor (ER)-α in immune cells |
1714: Exacerbation of systemic lupus erythematosus (SLE) |
Under Development |
1.73 |
315 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Yasuhiro Yoshida |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1715: Inhibition of JAK3 |
1719: Impairment of T-cell dependent antibody response |
Under Development |
1.74 |
316 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Shigeru Hisada |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1720: Trypsin inhibition |
1725: Pancreatic acinar cell tumors |
Under Development |
1.60 |
319 |
Binding to ACE2 leading to lung fibrosis |
Young Jun Kim |
Open for comment. Do not cite |
Included in OECD Work Plan |
1740: ACE2 inhibition |
1276: Lung fibrosis |
Under Development |
1.96 |
320 |
Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality |
Young Jun Kim |
Open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
351: Increased Mortality |
Under Development |
1.96 |
348 |
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1799: Inhibition of 11β-HSD |
360: Decrease, Population trajectory |
Under Development |
1.93 |
349 |
Inhibition of 11β-hydroxylase leading to decresed population trajectory |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1796: 11β-hydroxylase inhibition |
360: Decrease, Population trajectory |
Under Development |
1.93 |
358 |
Chitinase inhibition leading to mortality |
Simon Schmid |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1806: Increase, Chitinase inhibition |
350: Increase, Mortality |
Under Development |
1.94 |
359 |
Chitobiase inhibition leading to mortality |
Simon Schmid |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1807: Increase, Chitobiase inhibition |
350: Increase, Mortality |
Under Development |
1.94 |
361 |
Sulfonylureareceptor binding leading to mortality |
Simon Schmid |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1525: Increase, Sulfonylurea receptor binding |
350: Increase, Mortality |
Under Development |
1.94 |
374 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Anna Price |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1841: Encephalitis |
Under Development |
1.96 |
379 |
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation |
Shihori Tanabe |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1738: Increased susceptibility to viral entry |
1847: Increased coronavirus production and 1846: Thrombosis and Disseminated Intravascular Coagulation |
Under Development |
1.96 |
381 |
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1850: dysgeusia |
Under Development |
1.96 |
382 |
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) |
1276: Lung fibrosis |
Under Development |
1.96 |
383 |
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1740: ACE2 inhibition |
344: N/A, Liver fibrosis |
Under Development |
1.96 |
392 |
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation |
Penny Nymark |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1866: Fibrinolysis, decreased and 1867: Bradykinin system, hyperactivated |
1868: Hyperinflammation |
Under Development |
1.96 |
394 |
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) |
Sandra Coecke |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1873: impaired olfactory function (anosmia) |
Under Development |
1.96 |
395 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) |
Magda Sachana |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1875: Cerebrovascular disease (stroke) |
Under Development |
1.96 |
398 |
Inhibition of ALDH1A (RALDH) causing reduced all-trans retinoic acid levels leading to impaired fertility, females |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1880: Inhibition of ALDH1A2 (RALDH2) |
972: Decreased fertility, Reduced number of oocytes ovulated |
Under Development |
1.97 |
412 |
Endothelial cell dysfunction leading to thromboinflammation |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1916: Thromboinflammation, Increased |
Under Development |
1.96 |
422 |
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption |
Laure-Alix Clerbaux |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1932: Gastrointestinal disorders |
Under Development |
1.96 |
428 |
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis |
Laure-Alix Clerbaux |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
|
Under Development |
1.96 |
430 |
Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation |
Sally Mayasich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
1739: ACE2 binding to viral S-protein |
1939: Viral infection and host-to-host transmission, proliferated |
Under Development |
1.96 |