3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits |
Andrea Terron |
Open for citation & comment |
Included in OECD Work Plan |
NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor |
Motor function, impaired |
TFHA/WNT Endorsed |
1.33 |
6 |
Antagonist binding to PPARα leading to body-weight loss |
Kurt A. Gust |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
starvation-like body-weight loss |
TFHA/WNT Endorsed |
2.3 |
10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain |
Ping Gong |
Open for citation & comment |
Included in OECD Work Plan |
GABA |
epileptic seizures |
TFHA/WNT Endorsed |
1.15 |
12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging |
Florianne Tschudi-Monnet |
Open for citation & comment |
Included in OECD Work Plan |
NMDAR |
neuroinflammation and lead to neurodegeneration |
TFHA/WNT Endorsed |
1.13 |
13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
NMDAR |
impairment of learning and memory abilities |
TFHA/WNT Endorsed |
1.22 |
15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations |
Carole Yauk |
Open for citation & comment |
Included in OECD Work Plan |
DNA alkylation |
heritable mutations |
TFHA/WNT Endorsed |
1.11 |
21 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 |
Markus Hecker |
Open for citation & comment |
Included in OECD Work Plan |
AhR |
embryo toxicity |
TFHA/WNT Endorsed |
1.27 |
23 |
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
AR |
reproductive dysfunction |
TFHA/WNT Endorsed |
1.12 |
25 |
Aromatase inhibition leading to reproductive dysfunction |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
Aromatate Inhib |
reproductive dysfunction |
TFHA/WNT Endorsed |
1.12 |
38 |
Protein Alkylation leading to Liver Fibrosis |
Brigitte Landesmann |
Open for citation & comment |
Included in OECD Work Plan |
Protein alkylation |
liver fibrosis |
TFHA/WNT Endorsed |
1.14 |
40 |
Covalent Protein binding leading to Skin Sensitisation |
Sharon Munn |
Open for citation & comment |
Included in OECD Work Plan |
Covalent Binding, Protein |
sensitisation, skin |
TFHA/WNT Endorsed |
1.1 |
42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
Open for citation & comment |
Included in OECD Work Plan |
TPO |
neurodevelopmental outcomes |
TFHA/WNT Endorsed |
1.10 |
48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
Glutamate Receptor |
learning and memory impairment. |
TFHA/WNT Endorsed |
1.23 |
54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
NIS |
learning and memory deficits in children |
TFHA/WNT Endorsed |
1.28 |
131 |
Aryl hydrocarbon receptor activation leading to uroporphyria |
Amani Farhat |
Open for citation & comment |
Included in OECD Work Plan |
AhR |
uroporphyria |
TFHA/WNT Endorsed |
1.7 |
150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF |
Amani Farhat |
Open for citation & comment |
Included in OECD Work Plan |
Activation, AhR |
Increase, Early Life Stage Mortality |
TFHA/WNT Endorsed |
1.7 |
7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female |
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
impaired fertility |
EAGMST Under Review |
1.21 |
17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory |
Marie-Gabrielle Zurich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
multiple |
neuroinflammation leading to neurodegeneration |
EAGMST Under Review |
1.13 |
18 |
PPARα activation in utero leading to impaired fertility in males |
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
impaired fertility |
EAGMST Under Review |
1.21 |
30 |
Estrogen receptor antagonism leading to reproductive dysfunction |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
ER |
reproductive dysfunction |
EAGMST Under Review |
1.12 |
41 |
Sustained AhR Activation leading to Rodent Liver Tumours |
Rick Becker |
Open for citation & comment |
Included in OECD Work Plan |
AhR |
liver tumors |
EAGMST Under Review |
1.7 |
43 |
Disruption of VEGFR Signaling Leading to Developmental Defects |
Tom Knudsen |
Open for citation & comment |
Included in OECD Work Plan |
VEGF |
developmental outcomes |
EAGMST Under Review |
1.6 |
46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) |
Ted Simon |
Open for citation & comment |
Included in OECD Work Plan |
AFB1 |
hepatocellular carcinoma |
EAGMST Under Review |
1.8 |
106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring |
Francesco Marchetti |
Open for citation & comment |
Included in OECD Work Plan |
tubulin? |
aneuploid offspring |
EAGMST Under Review |
1.11 |
107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat |
Kristin Lichti-Kaiser |
Open for citation & comment |
Included in OECD Work Plan |
CAR |
hepatocellular adenomas and carcinomas |
EAGMST Under Review |
1.17 |
136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors |
Justin Teeguarden |
Open for citation & comment |
Included in OECD Work Plan |
unclear |
contact nasal tumors |
EAGMST Under Review |
2.7 |
144 |
Endocytic lysosomal uptake leading to liver fibrosis |
Marina Kuburic |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
Liver, Inflammation |
EAGMST Under Review |
1.47 |
154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response |
Takumi Ohishi |
Open for comment. Do not cite |
Included in OECD Work Plan |
Calcineurin Activity, Inhibition |
|
EAGMST Under Review |
1.38 |
155 |
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.35 |
156 |
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.35 |
157 |
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.35 |
158 |
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.35 |
159 |
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.35 |
173 |
Substance interaction with the lung resident cell membrane components leading to lung fibrosis |
Sabina Halappanavar |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.32 |
202 |
Inhibitor binding to topoisomerase II leading to infant leukaemia |
Andrea Terron |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.53 |
212 |
Histone deacetylase inhibition leading to testicular atrophy |
Shihori Tanabe |
Open for citation & comment |
Included in OECD Work Plan |
Histone deacetylase, inhibition |
testicular toxicity |
EAGMST Under Review |
1.52 |
220 |
Cyp2E1 Activation Leading to Liver Cancer |
Francina Webster |
Open for citation & comment |
Included in OECD Work Plan |
Activation of Cyp2E1 |
liver cancer |
EAGMST Under Review |
1.24 |
272 |
Direct deposition of ionizing energy leading to lung cancer |
Vinita Chauhan |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.56 |
277 |
Impaired IL-1R1 signaling leading to increased susceptibility to infection |
Yutaka Kimura |
Open for citation & comment |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.48 |
282 |
Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions |
Satomi Onoue |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.49 |
296 |
Oxidative DNA damage leading to chromosomal aberrations and mutations |
Carole Yauk |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.76 |
298 |
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer |
Shihori Tanabe |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.58 |
8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Katie Paul Friedman |
Not under active development |
Included in OECD Work Plan |
mulitple |
neurodevelopmental outcomes |
Under Development |
1.9 |
11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol |
Jun Kanno |
Not under active development |
Included in OECD Work Plan |
|
case study |
Under Development |
2.5 |
16 |
Acetylcholinesterase inhibition leading to acute mortality |
Dan Villeneuve |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
AChE |
acute mortality |
Under Development |
1.3 |
27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Mathieu Vinken |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
ABCB11 |
cholestatic liver injury |
Under Development |
1.19 |
31 |
Oxidation of iron in hemoglobin leading to hematotoxicity |
Mitchell S. Wilbanks |
Open for adoption |
Included in OECD Work Plan |
heme oxidation ? |
hematotoxicity |
Under Development |
1.16 |
35 |
Narcosis leading to respiratory failure |
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
undefined |
sensitisation of the respiratory tract |
Under Development |
1.2 |
37 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Chris Corton |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
PPAR alpha |
liver cancer |
Under Development |
1.17 |
39 |
Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract |
Kristie Sullivan |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
unclear what proteins |
sensitisation of the respiratory tract |
Under Development |
1.20 |
51 |
PPARα activation leading to impaired fertility in adult male rodents |
Elise Grignard |
Not under active development |
Included in OECD Work Plan |
PPAR α |
impaired fertility |
Under Development |
1.21 |
117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Open for adoption |
Included in OECD Work Plan |
AR |
adenomas and carcinomas |
Under Development |
1.26 |
128 |
Kidney dysfunction by decreased thyroid hormone |
Jung-Hwa Oh |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
unclear - KE as MIE? |
kidnney dysfunction |
Under Development |
1.40 |
130 |
Phospholipase A inhibitors lead to hepatotoxicity |
Jung-Hwa Oh |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
phospolipase A |
hepatotoxicity |
Under Development |
1.39 |
148 |
EGFR Activation Leading to Decreased Lung Function |
Karsta Luettich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
EGFR |
|
Under Development |
1.51 |
149 |
Peptide Oxidation Leading to Hypertension |
Frazer Lowe |
Not under active development |
Included in OECD Work Plan |
|
|
Under Development |
1.50 |
151 |
AhR activation leading to preeclampsia |
Sabrina Tait |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.42 |
152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity |
Kristie Sullivan |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
Transthyretin |
|
Under Development |
1.41 |
187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage |
Barnett Rattner |
Not under active development |
Included in OECD Work Plan |
|
|
Under Development |
1.31 |
206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.54 |
237 |
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression |
Sarah Søs Poulsen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.55 |
256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Angela Mally |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.43 |
257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Angela Mally |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.43 |
258 |
Renal protein alkylation leading to kidney toxicity |
Angela Mally |
Not under active development |
Included in OECD Work Plan |
|
|
Under Development |
1.43 |
261 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
262 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
263 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (1) |
You Song |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.92 |
264 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (2) |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.92 |
265 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (3) |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.92 |
266 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (4) |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.92 |
267 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (5) |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.92 |
268 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (6) |
You Song |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.92 |
271 |
Inhibition of thyroid peroxidase leading to impaired fertility in fish |
June-Woo Park |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.59 |
283 |
L-type calcium channel blockade leading to hypotension |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
289 |
Inhibition of 5α-reductase leading to impaired fecundity in female fish |
Young Jun Kim |
Open for citation & comment |
Included in OECD Work Plan |
|
|
Under Development |
1.81 |
292 |
Inhibition of tyrosinase leads to decreased population in fish |
Young Jun Kim |
Open for citation & comment |
Included in OECD Work Plan |
|
|
Under Development |
1.78 |
293 |
Increased DNA damage leading to increased risk of breast cancer |
Jessica Helm |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.80 |
294 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Jessica Helm |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.80 |
295 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Andrea Hindman |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.79 |
297 |
Inhibition of retinaldehyde dehydrogenase leads to population decline |
Young Jun Kim |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
|
|
Under Development |
1.77 |
300 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
Thyroid Receptor Antagonism |
Cognitve function, Decreased |
Under Development |
1.84 |
302 |
Lung surfactant function inhibition leading to impaired lung function |
Jorid Birkelund Sørli |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.87 |
303 |
Frustrated phagocytosis-induced lung cancer |
Carole Seidel |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.86 |
305 |
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.90 |
306 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.90 |
307 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.90 |
313 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Hiroyuki Komatsu |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.75 |
314 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Yasuharu Otsubo |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.73 |
315 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Yasuhiro Yoshida |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.74 |
316 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Shigeru Hisada |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.60 |