AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired TFHA/WNT Endorsed 1.33
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for citation & comment Included in OECD Work Plan PPAR starvation-like body-weight loss TFHA/WNT Endorsed 2.3
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong Open for citation & comment Included in OECD Work Plan GABA epileptic seizures TFHA/WNT Endorsed 1.15
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration TFHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker Open for citation & comment Included in OECD Work Plan AhR embryo toxicity TFHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction TFHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Sharon Munn Open for citation & comment Included in OECD Work Plan Covalent Binding, Protein sensitisation, skin TFHA/WNT Endorsed 1.1
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes TFHA/WNT Endorsed 1.10
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for citation & comment Included in OECD Work Plan NIS learning and memory deficits in children TFHA/WNT Endorsed 1.28
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for citation & comment Included in OECD Work Plan AhR uroporphyria TFHA/WNT Endorsed 1.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Open for citation & comment Included in OECD Work Plan Activation, AhR Increase, Early Life Stage Mortality TFHA/WNT Endorsed 1.7
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration EAGMST Under Review 1.13
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti Open for citation & comment Included in OECD Work Plan tubulin? aneuploid offspring EAGMST Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.17
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation EAGMST Under Review 1.47
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi Open for comment. Do not cite Included in OECD Work Plan Calcineurin Activity, Inhibition EAGMST Under Review 1.38
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Sabina Halappanavar Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.32
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe Under development: Not open for comment. Do not cite Included in OECD Work Plan Histone deacetylase, inhibition testicular toxicity EAGMST Under Review 1.52
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster Open for citation & comment Included in OECD Work Plan Activation of Cyp2E1 liver cancer EAGMST Under Review 1.24
272 Direct deposition of ionizing energy leading to lung cancer Vinita Chauhan Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.56
277 Inhibition of IL-1 binding to IL-1 receptor leading to increased susceptibility to infection Yutaka Kimura Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.48
282 Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Satomi Onoue Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.49
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.76
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Not under active development Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Not under active development Included in OECD Work Plan case study Under Development 2.5
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under Development: Contributions and Comments Welcome Included in OECD Work Plan AChE acute mortality Under Development 1.3
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Open for adoption Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
37 PPARalpha-dependent liver cancer Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
39 Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan Under Development: Contributions and Comments Welcome Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Not under active development Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
130 Phospholipase A inhibitors lead to hepatotoxicity Jung-Hwa Oh Under Development: Contributions and Comments Welcome Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Not under active development Included in OECD Work Plan Under Development 1.50
151 AhR activation leading to placental insufficiency Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus Open for adoption Included in OECD Work Plan Under Development 1.41
155 Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
156 Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
157 Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
158 Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
159 Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Not under active development Included in OECD Work Plan Under Development 1.31
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.54
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.55
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
258 Renal protein alkylation leading to kidney toxicity Angela Mally Not under active development Included in OECD Work Plan Under Development 1.43
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park Open for comment. Do not cite Included in OECD Work Plan Under Development 1.59
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim Open for citation & comment Included in OECD Work Plan Under Development 1.81
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim Open for citation & comment Included in OECD Work Plan Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.79
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim Under Development: Contributions and Comments Welcome Included in OECD Work Plan Under Development 1.77
298 Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Shihori Tanabe Under Development: Contributions and Comments Welcome Included in OECD Work Plan Under Development 1.58
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Under development: Not open for comment. Do not cite Included in OECD Work Plan Thyroid Receptor Antagonism Cognitve function, Decreased Under Development 1.84
302 Lung surfactant function disruption leading to sudden adverse lung effects Jorid Birkelund Sørli Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Carole Seidel Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.86
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.74
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.60