3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits |
Andrea Terron |
BY-SA |
- Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
|
- Parkinsonian motor deficits
| WPHA/WNT Endorsed |
1.33 |
6 |
Antagonist binding to PPARα leading to body-weight loss |
Kurt A. Gust |
BY-SA |
- Binding of antagonist, PPAR alpha
|
| WPHA/WNT Endorsed |
2.3 |
7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female |
Elise Grignard |
BY-SA |
- reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
|
- impaired, Fertility
- irregularities, ovarian cycle
| EAGMST Under Review |
1.21 |
8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Katie Paul Friedman |
Open for adoption |
- Activation, Pregnane-X receptor, NR1l2
|
| Under Development |
1.9 |
10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain |
Ping Gong |
BY-SA |
- Binding at picrotoxin site, iGABAR chloride channel
|
- Occurrence, Epileptic seizure
| WPHA/WNT Endorsed |
1.15 |
11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol |
Jun Kanno |
BY-SA |
|
| Under Development |
2.5 |
12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging |
Florianne Tschudi-Monnet |
BY-SA |
- Binding of antagonist, NMDA receptors
|
- N/A, Neurodegeneration
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.13 |
13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities |
Anna Price |
BY-SA |
- Binding of antagonist, NMDA receptors
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.22 |
15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations |
Carole Yauk |
BY-SA |
|
- Increase, Heritable mutations in offspring
| WPHA/WNT Endorsed |
1.11 |
16 |
Acetylcholinesterase inhibition leading to acute mortality |
Dan Villeneuve |
BY-SA |
- Acetylcholinesterase (AchE) Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.3 |
17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory |
Marie-Gabrielle Zurich |
BY-SA |
- Binding, Thiol/seleno-proteins involved in protection against oxidative stress
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.13 |
18 |
PPARα activation in utero leading to impaired fertility in males |
Elise Grignard |
BY-SA |
|
- impaired, Fertility
- Malformation, Male reproductive tract
| EAGMST Under Review |
1.21 |
21 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 |
Markus Hecker |
BY-SA |
|
| WPHA/WNT Endorsed |
1.27 |
23 |
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) |
Dan Villeneuve |
BY-SA |
- Agonism, Androgen receptor
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
25 |
Aromatase inhibition leading to reproductive dysfunction |
Dan Villeneuve |
BY-SA |
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Mathieu Vinken |
BY-SA |
- Inhibition, Bile Salt Export Pump (ABCB11)
|
| Under Development |
1.19 |
30 |
Estrogen receptor antagonism leading to reproductive dysfunction |
Dan Villeneuve |
BY-SA |
- Antagonism, Estrogen receptor
|
- Decrease, Population growth rate
| EAGMST Under Review |
1.12 |
31 |
Oxidation of iron in hemoglobin leading to hematotoxicity |
Mitchell S. Wilbanks |
Open for adoption |
- N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
|
| Under Development |
1.16 |
35 |
Narcosis leading to respiratory failure |
Dries Knapen |
BY-SA |
- Accumulation, Biological membranes
|
| Under Development |
1.2 |
37 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Chris Corton |
BY-SA |
|
- Increase, hepatocellular adenomas and carcinomas
| Under Development |
1.17 |
38 |
Protein Alkylation leading to Liver Fibrosis |
Brigitte Landesmann |
BY-SA |
|
| WPHA/WNT Endorsed |
1.14 |
39 |
Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response |
Jessica Ponder |
BY-SA |
- Covalent Binding, Protein
|
- Increase, Allergic Respiratory Hypersensitivity Response
| Under Development |
1.20 |
40 |
Covalent Protein binding leading to Skin Sensitisation |
Sharon Munn |
BY-SA |
- Covalent Binding, Protein
|
| WPHA/WNT Endorsed |
1.1 |
41 |
Sustained AhR Activation leading to Rodent Liver Tumours |
Rick Becker |
BY-SA |
- Activation, Long term AHR receptor driven direct and indirect gene expression changes
|
- Formation, Hepatocellular and Bile duct tumors
| EAGMST Under Review |
1.7 |
42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Cognitive Function, Decreased
| WPHA/WNT Endorsed |
1.10 |
43 |
Disruption of VEGFR Signaling Leading to Developmental Defects |
Tom Knudsen |
BY-SA |
|
- Increased, Developmental Defects
| WPHA/WNT Endorsed |
1.6 |
46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) |
Ted Simon |
BY-SA |
- Formation, Pro-mutagenic DNA Adducts
|
- Tumorigenesis, Hepatocellular carcinoma
| EAGMST Under Review |
1.8 |
48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. |
Anna Price |
BY-SA |
- Binding of agonist, Ionotropic glutamate receptors
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.23 |
51 |
PPARα activation leading to impaired fertility in adult male rodents |
Elise Grignard |
BY-SA |
|
| Under Development |
1.21 |
54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment |
Anna Price |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Impairment, Learning and memory
| WPHA/WNT Endorsed |
1.28 |
106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring |
Francesco Marchetti |
BY-SA |
|
- Increase, Aneuploid offspring
| EAGMST Under Review |
1.11 |
107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat |
Kristin Lichti-Kaiser |
BY-SA |
- Activation, Constitutive androstane receptor
|
- Increase, hepatocellular adenomas and carcinomas
| EAGMST Under Review |
1.17 |
117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Open for adoption |
- Activation, Androgen receptor
|
- Increase, hepatocellular adenomas and carcinomas
| Under Development |
1.26 |
128 |
Kidney dysfunction by decreased thyroid hormone |
Jung-Hwa Oh |
BY-SA |
- Thyroid hormone synthesis, Decreased
|
- Occurrence, Kidney toxicity
| Under Development |
1.40 |
130 |
Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity |
Jung-Hwa Oh |
BY-SA |
- Inhibition, Phospholipase A
|
- Formation, Liver fibrosis
| Under Development |
1.39 |
131 |
Aryl hydrocarbon receptor activation leading to uroporphyria |
Amani Farhat |
BY-SA |
|
| WPHA/WNT Endorsed |
1.7 |
136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors |
Justin Teeguarden |
BY-SA |
- Decrease, Intracellular pH
|
- Increase, Site of Contact Nasal Tumors
| EAGMST Under Review |
2.7 |
144 |
Endocytic lysosomal uptake leading to liver fibrosis |
Marina Kuburic |
BY-SA |
- Endocytotic lysosomal uptake
|
| EAGMST Under Review |
1.47 |
148 |
EGFR Activation Leading to Decreased Lung Function |
Karsta Luettich |
BY-SA |
|
| Under Development |
1.51 |
149 |
Peptide Oxidation Leading to Hypertension |
Frazer Lowe |
BY-SA |
|
| Under Development |
1.50 |
150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF |
Amani Farhat |
BY-SA |
|
- Increase, Early Life Stage Mortality
| WPHA/WNT Endorsed |
1.7 |
151 |
AhR activation leading to preeclampsia |
Sabrina Tait |
All rights reserved |
|
| Under Development |
1.42 |
152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity |
Kristie Sullivan |
BY-SA |
- Binding, Transthyretin in serum
|
- Cognitive Function, Decreased
| Under Development |
1.41 |
154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response |
Takumi Ohishi |
BY-SA |
- Inhibition, Calcineurin Activity
|
- Impairment, T-cell dependent antibody response
| WPHA/WNT Endorsed |
1.38 |
155 |
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
156 |
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
157 |
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
158 |
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
159 |
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.35 |
173 |
Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis |
Sabina Halappanavar |
All rights reserved |
- Substance interaction with the lung resident cell membrane components
|
| WPHA/WNT Endorsed |
1.32 |
187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage |
Barnett Rattner |
BY-SA |
- Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
- Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
- Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
|
- Impaired recruitment , Population trajectory
| Under Development |
1.31 |
202 |
Inhibitor binding to topoisomerase II leading to infant leukaemia |
Andrea Terron |
BY-SA |
- Binding to (interferes with) topoisomerase II enzyme
|
| WPHA/WNT Endorsed |
1.53 |
206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Jinhee Choi |
All rights reserved |
|
| Under Development |
1.54 |
212 |
Histone deacetylase inhibition leading to testicular atrophy |
Shihori Tanabe |
BY-SA |
- Histone deacetylase inhibition
|
| WPHA/WNT Endorsed |
1.52 |
220 |
Cyp2E1 Activation Leading to Liver Cancer |
Francina Webster |
BY-SA |
|
| WPHA/WNT Endorsed |
1.24 |
237 |
Substance interaction with lung resident cell membrane components leading to atherosclerosis |
Ulla Vogel |
BY-SA |
- Substance interaction with the lung resident cell membrane components
|
| Under Development |
1.55 |
256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Angela Mally |
BY-SA |
- Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Angela Mally |
BY-SA |
- Binding of substrate, endocytic receptor
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
258 |
Renal protein alkylation leading to kidney toxicity |
Angela Mally |
BY-SA |
|
- Occurrence, Kidney toxicity
| Under Development |
1.43 |
261 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Luigi Margiotta-Casaluci |
All rights reserved |
- Blockade, L-Type Calcium Channels
|
| Under Development |
1.45 |
262 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Luigi Margiotta-Casaluci |
All rights reserved |
|
| Under Development |
1.45 |
263 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| WPHA/WNT Endorsed |
1.92 |
264 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
265 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
266 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
267 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
268 |
Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling |
You Song |
BY-SA |
- Decrease, Coupling of oxidative phosphorylation
|
| Under Development |
1.92 |
271 |
Inhibition of thyroid peroxidase leading to impaired fertility in fish |
June-Woo Park |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Reduction, Cumulative fecundity and spawning
| Under Development |
1.59 |
272 |
Deposition of energy leading to lung cancer |
Vinita Chauhan |
BY-SA |
|
| WPHA/WNT Endorsed |
1.56 |
277 |
Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response |
Takao Ashikaga |
BY-SA |
- Impaired IL-1R1 signaling in T cell
|
- Impairment, T-cell dependent antibody response
| WPHA/WNT Endorsed |
1.48 |
282 |
Adverse outcome pathway on photochemical toxicity initiated by light exposure |
Satomi Onoue |
BY-SA |
- ROS generation from photoactivated chemicals
|
- Inflamatory events in light-exposed tissues
| EAGMST Under Review |
1.49 |
283 |
L-type calcium channel blockade leading to hypotension |
Luigi Margiotta-Casaluci |
All rights reserved |
|
| Under Development |
1.45 |
289 |
Inhibition of 5α-reductase leading to impaired fecundity in female fish |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.81 |
292 |
Inhibition of tyrosinase leads to decreased population in fish |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.78 |
293 |
Increased DNA damage leading to increased risk of breast cancer |
Jessica Helm |
BY-SA |
|
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
| Under Development |
1.80 |
294 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Jessica Helm |
BY-SA |
- Increase in reactive oxygen and nitrogen species (RONS)
|
- Increase, DNA damage
- Increase, Mutations
- Increased, Ductal Hyperplasia
- N/A, Breast Cancer
| Under Development |
1.80 |
295 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Andrea Hindman |
BY-SA |
|
| Under Development |
1.79 |
296 |
Oxidative DNA damage leading to chromosomal aberrations and mutations |
Carole Yauk |
BY-SA |
- Increase, Oxidative damage to DNA
|
- Increase, Mutations
- Increase, Chromosomal aberrations
| WPHA/WNT Endorsed |
1.76 |
297 |
Inhibition of retinaldehyde dehydrogenase leads to population decline |
Young Jun Kim |
BY-SA |
- Retinaldehyde dehydrogenase inhibition
|
- Decrease, Population growth rate
| Under Development |
1.77 |
298 |
Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer |
Shihori Tanabe |
BY-SA |
- Increases in cellular reactive oxygen species
- Chronic reactive oxygen species
|
- Treatment-resistant gastric cancer
| EAGMST Under Review |
1.58 |
300 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
BY-SA |
- Antagonism, Thyroid Receptor
|
- Cognitive Function, Decreased
| Under Development |
1.84 |
302 |
Lung surfactant function inhibition leading to decreased lung function |
Jorid Birkelund Sørli |
BY-SA |
- Inhibition of lung surfactant function
|
| Under Development |
1.87 |
303 |
Frustrated phagocytosis-induced lung cancer |
Carole Seidel |
BY-SA |
|
| Under Development |
1.86 |
305 |
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
306 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
307 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
|
- anogenital distance (AGD), decreased
| Under Development |
1.90 |
313 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Hiroyuki Komatsu |
BY-SA |
|
| Under Development |
1.75 |
314 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Yasuharu Otsubo |
BY-SA |
- Binding to estrogen receptor (ER)-α in immune cells
|
- Exacerbation of systemic lupus erythematosus (SLE)
| Under Development |
1.73 |
315 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Yasuhiro Yoshida |
BY-SA |
|
- Impairment of T-cell dependent antibody response
| Under Development |
1.74 |
316 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Shigeru Hisada |
BY-SA |
|
- Pancreatic acinar cell tumors
| Under Development |
1.60 |
319 |
Binding to ACE2 leading to lung fibrosis |
Young Jun Kim |
BY-SA |
- Induced dysregulation of ACE2
|
| Under Development |
1.96 |
320 |
Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality |
Young Jun Kim |
BY-SA |
|
| Under Development |
1.96 |
344 |
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
- Nipple retention (NR), increased
| Under Development |
1.108 |
345 |
Androgen receptor (AR) antagonism leading to decreased fertility in females |
Terje Svingen |
BY-SA |
- Antagonism, Androgen receptor
|
| Under Development |
1.109 |
346 |
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Kelvin Santana Rodriguez |
BY-SA |
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
348 |
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory |
Young Jun Kim |
BY-SA |
|
- Decrease, Population growth rate
| Under Development |
1.93 |
349 |
Inhibition of 11β-hydroxylase leading to decresed population trajectory |
Young Jun Kim |
BY-SA |
- 11β-hydroxylase inhibition
|
- Decrease, Population growth rate
| Under Development |
1.93 |
358 |
Chitinase inhibition leading to mortality |
Simon Schmid |
All rights reserved |
|
| Under Development |
1.94 |
359 |
Chitobiase inhibition leading to mortality |
Simon Schmid |
All rights reserved |
|
| Under Development |
1.94 |
360 |
Chitin synthase 1 inhibition leading to mortality |
Simon Schmid |
BY-SA |
- Inhibition, Chitin synthase 1
|
| WPHA/WNT Endorsed |
1.94 |
361 |
Sulfonylureareceptor binding leading to mortality |
Simon Schmid |
All rights reserved |
- Increase, Sulfonylurea receptor binding
|
| Under Development |
1.94 |
363 |
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure |
Lucia Vergauwen |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| EAGMST Under Review |
1.35 |
364 |
Thyroperoxidase inhibition leading to altered visual function via decreased eye size |
Lucia Vergauwen |
All rights reserved |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.35 |
365 |
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning |
Lucia Vergauwen |
All rights reserved |
- Thyroperoxidase, Inhibition
|
- Increased Mortality
- Decrease, Population growth rate
| Under Development |
1.35 |
374 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis |
Anna Price |
All rights reserved |
|
| Under Development |
1.96 |
376 |
Androgen receptor agonism leading to male-biased sex ratio |
Dan Villeneuve |
BY-SA |
- Agonism, Androgen receptor
|
- Decrease, Population growth rate
| WPHA/WNT Endorsed |
1.12 |
379 |
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation |
Shihori Tanabe |
All rights reserved |
|
- Thrombosis and Disseminated Intravascular Coagulation
| Under Development |
1.96 |
381 |
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia |
Young Jun Kim |
BY-SA |
|
| Under Development |
1.96 |
382 |
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis |
Young Jun Kim |
BY-SA |
- Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
|
| Under Development |
1.96 |
383 |
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis |
Young Jun Kim |
BY-SA |
- Induced dysregulation of ACE2
|
| Under Development |
1.96 |
392 |
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation |
Penny Nymark |
BY-SA |
- Fibrinolysis, decreased
- Bradykinin system, hyperactivated
|
| Under Development |
1.96 |
394 |
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) |
Sandra Coecke |
BY-SA |
|
- impaired olfactory function (anosmia)
| Under Development |
1.96 |
395 |
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) |
Magda Sachana |
BY-SA |
|
- Cerebrovascular disease (stroke)
| Under Development |
1.96 |
397 |
Bulky DNA adducts leading to mutations |
Carole Yauk |
BY-SA |
- Bulky DNA adducts, increase
|
| Under Development |
1.11 |
398 |
Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary |
Terje Svingen |
BY-SA |
- Inhibition of ALDH1A (RALDH)
|
| Under Development |
1.97 |
412 |
Endothelial cell dysfunction leading to thromboinflammation |
Luigi Margiotta-Casaluci |
All rights reserved |
|
- Thromboinflammation, Increased
| Under Development |
1.96 |
422 |
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption |
Laure-Alix Clerbaux |
BY-SA |
|
| Under Development |
1.96 |
428 |
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis |
Laure-Alix Clerbaux |
BY-SA |
|
| Under Development |
1.96 |
430 |
Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation |
Sally Mayasich |
All rights reserved |
|
- Viral infection and host-to-host transmission, proliferated
| Under Development |
1.96 |
437 |
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity |
Baki Sadi |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Occurrence, Kidney toxicity
| Under Development |
1.99 |
439 |
Activation of the AhR leading to metastatic breast cancer |
Louise Benoit |
BY-SA |
|
| Under Development |
1.105 |
440 |
Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia |
Kalyan Gayen |
All rights reserved |
- Suppression, Estrogen receptor (ER) activity
|
- Promotion, ovarian adenomas
- Promotion, Ovarian Cancer
| Under Development |
1.104 |
442 |
Binding to voltage gate sodium channels during development leads to cognitive impairment |
Iris Mangas |
BY-SA |
- Binding to voltage-gated sodium channel
|
- Impairment, Learning and memory
| Under Development |
1.91 |
443 |
DNA damage and mutations leading to Metastatic Breast Cancer |
Usha Adiga |
BY-SA |
- Increased, DNA damage and mutation
|
| Under Development |
1.103 |
455 |
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development |
Prarthana Shankar |
BY-SA |
|
- Increase, Early Life Stage Mortality
- Facial cartilage structures are reduced in size and morphologically distorted
| EAGMST Under Review |
|
456 |
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity |
Prarthana Shankar |
BY-SA |
|
- Increase, Early Life Stage Mortality
| EAGMST Under Review |
|
460 |
Antagonism of Smoothened receptor leading to orofacial clefting |
Jacob Reynolds |
All rights reserved |
- Antagonism, Smoothened receptor
|
| Under Development |
1.101 |
474 |
Succinate dehydrogenase inactivation leading to cancer |
Sylvie Bortoli |
BY-SA |
|
| Under Development |
1.106 |
475 |
Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons |
Shihori Tanabe |
All rights reserved |
- Binding of agonist, Ionotropic glutamate receptors
|
- Impairment, Learning and memory
| Under Development |
1.107 |
479 |
Mitochondrial complexes inhibition leading to heart failure via increased myocardial oxidative stress |
Sivakumar Murugadoss |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Heart failure
- Increase, Mortality
| Under Development |
1.102 |
480 |
Mitochondrial complexes inhibition leading to heart failure via decreased ATP production |
Alexandra Schaffert |
BY-SA |
- Inhibition, Mitochondrial Electron Transport Chain Complexes
|
- Heart failure
- Increase, Mortality
| Under Development |
1.102 |
491 |
Decrease, GLI1/2 target gene expression leads to orofacial clefting |
Jacob Reynolds |
All rights reserved |
- Decrease, GLI1/2 target gene expression
|
| Under Development |
1.101 |
502 |
Decrease, cholesterol synthesis leads to orofacial clefting |
Jacob Reynolds |
All rights reserved |
|
| Under Development |
1.101 |
4 |
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality |
Knut Erik Tollefsen |
BY-SA |
- Increase, Ecdysone receptor agonism
|
| |
|
19 |
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) |
Mukesh Patel |
Open for adoption |
- N/A, Androgen receptor, Antagonism
|
- N/A, Impairment of reproductive capacity
| |
|
26 |
Calcium-mediated neuronal ROS production and energy imbalance |
Lyle Burgoon |
Open for adoption |
|
- Increased, Oxidative damage
| |
|
28 |
Cyclooxygenase inhibition leading reproductive failure |
Dan Villeneuve |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- N/A, Reproductive failure
| |
1.29 |
29 |
Estrogen receptor agonism leading to reproductive dysfunction |
Tom Hutchinson |
BY-SA |
- Agonism, Estrogen receptor
|
- Decrease, Population growth rate
- Altered, Reproductive behaviour
- Altered, Larval development
- Impaired development of, Reproductive organs
| |
1.29 |
32 |
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors |
Michelle Embry |
BY-SA |
|
| |
|
33 |
Kidney toxicity induced by activation of 5HT2C |
Kevin Crofton |
Open for adoption |
|
- Increased, Kidney Failure
| |
|
34 |
LXR activation leading to hepatic steatosis |
Marina Goumenou |
BY-SA |
- Activation, LXR
- peroxisome proliferator activated receptor promoter demethylation
|
| |
|
36 |
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis |
Michelle Angrish |
BY-SA |
- Decreased, PPAR-alpha activation
- Decreased, PPAR-beta activation
- Decreased, PPAR-gamma activation
|
- Increased, Liver Steatosis
| |
1.29 |
52 |
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males |
Tom Hutchinson |
BY-SA |
- Agonism, Estrogen receptor
|
| |
1.29 |
53 |
ER agonism leading to reduced survival due to renal failure |
Tom Hutchinson |
BY-SA |
- Agonism, Estrogen receptor
|
| |
1.29 |
57 |
AhR activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
|
- Accumulation, Liver lipid
| |
1.29 |
58 |
NR1I3 (CAR) suppression leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
- Suppression, Constitutive androstane receptor, NR1l3
- Inhibition, PPAR alpha
- Activation, LXR
- peroxisome proliferator activated receptor promoter demethylation
|
- Increased, Liver Steatosis
| |
1.29 |
59 |
HNF4alpha suppression leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
|
| |
1.29 |
60 |
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
|
- Increased, Liver Steatosis
| |
1.29 |
61 |
NFE2L2/FXR activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
- Activation, NRF2
- Activation, NR1H4
|
- Increased, Liver Steatosis
| |
1.29 |
62 |
AKT2 activation leading to hepatic steatosis |
Michelle Angrish |
BY-SA |
- systemic inflammation leading to hepatic steatosis
|
- Increased, Liver Steatosis
| |
1.29 |
63 |
Cyclooxygenase inhibition leading to reproductive dysfunction |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
64 |
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility |
Susan Laws |
BY-SA |
- Glucocorticoid Receptor Agonist, Activation
|
| |
1.29 |
66 |
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis |
Gary Klinefelter |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Increased corticosterone
- Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
| |
1.29 |
67 |
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis |
Gary Klinefelter |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Increased estradiol
- Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
| |
1.29 |
68 |
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome |
Gary Klinefelter |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
|
- Decreased sperm quantity / quality in the adult, Decreased fertility
| |
1.29 |
69 |
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell |
Gary Klinefelter |
BY-SA |
- Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
- Decreased Cholesterol, Decreased Uptake of Lipoproteins
- Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
|
- Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
| |
1.29 |
70 |
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell |
Gary Klinefelter |
BY-SA |
- Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
| |
1.29 |
71 |
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation |
Gary Klinefelter |
BY-SA |
- Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
|
- Decreased sperm quantity or quality in the adult, Decreased fertility
| |
1.29 |
72 |
Epigenetic modification of PPARG leading to adipogenesis |
Michelle Angrish |
BY-SA |
- peroxisome proliferator activated receptor promoter demethylation
- chronic high fat diet
|
| |
1.29 |
73 |
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity |
Tammy Stoker |
BY-SA |
- Inhibition, Inhibition of Dopamine-beta-hydroxylase
|
- Decreased, Decreased fecundity
| |
1.29 |
74 |
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis |
Gary Klinefelter |
BY-SA |
- Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
|
- Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
| |
1.29 |
77 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
78 |
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
79 |
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
80 |
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
- Decrease, Number of worker bees
- impaired, Hive thermoregulation
- Death/Failure, Colony
| |
1.29 |
81 |
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- Decrease, Number of worker bees
- Death/Failure, Colony
| |
1.29 |
82 |
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
84 |
Suppression of immune system contributes to impaired development and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- Decrease, Number of worker bees
- impaired, Hive thermoregulation
- Death/Failure, Colony
| |
1.29 |
85 |
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- Decrease, Number of worker bees
- Death/Failure, Colony
| |
1.29 |
86 |
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
87 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
88 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
89 |
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
90 |
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
- impaired, Larval development
- Death/Failure, Colony
| |
1.29 |
91 |
Sodium channel inhibition leading to reduced survival |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
- Reduced, feeding 1
- Increased, predation
- Reduced, survival
| |
1.29 |
93 |
sodium channel inhibition leading to increased predation |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
| |
1.29 |
94 |
Sodium channel inhibition leading to congenital malformations |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
| |
1.29 |
95 |
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival |
Kellie Fay |
BY-SA |
- Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
|
| |
1.29 |
96 |
Axonal sodium channel modulation leading to acute mortality |
Kellie Fay |
BY-SA |
- modulation, sodium channel
|
| |
1.29 |
97 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Increase, predation
- Decrease, Population growth rate
| |
1.29 |
99 |
Histamine (H2) receptor antagonism leading to reduced survival |
Kellie Fay |
BY-SA |
- Antagonism, Histamine Receptor (H2)
|
- Decreased, survival
- Increased, predation
| |
1.29 |
100 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
101 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
102 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
103 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Cyclooxygenase activity
|
- Reduced, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
104 |
Altered ion channel activity leading impaired heart function |
Kevin Dreher |
BY-SA |
|
| |
1.29 |
105 |
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
BY-SA |
- Increased, Binding of chemicals to 2u (serum)
|
- Increase, Adenomas/carcinomas (renal tubular)
| |
1.29 |
108 |
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
BY-SA |
- Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
|
- Increase, hepatocellular adenomas and carcinomas
| |
1.29 |
109 |
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (club cells)
|
- Increase, Adenomas/carcinomas (bronchioloalveolar)
| |
1.29 |
110 |
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Increase, Adenomas/carcinomas (follicular cell)
| |
1.29 |
111 |
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) |
Charles Wood |
BY-SA |
- Decreased, Androgen receptor activity
|
- Increase, Leydig cell tumors
| |
1.29 |
112 |
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) |
Charles Wood |
BY-SA |
- Increase, Dopaminergic activity
|
- Increase, Endometrial adenocarcinomas
| |
1.29 |
113 |
Glutamate-gated chloride channel activation leading to acute mortality |
Helen Poynton |
BY-SA |
- Activation, Glutamate-gated chloride channel
|
- Increased Mortality
- Decreased, population 1
| |
1.29 |
114 |
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) |
Charles Wood |
BY-SA |
- Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
|
- Increase, Papillomas/carcinomas (squamous cells)
| |
1.29 |
115 |
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (epithelial cells)
|
- Increase, Papillomas/carcinomas (squamous cells)
| |
1.29 |
116 |
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (tubular epithelial cells)
|
- Increase, Adenomas/carcinomas (renal tubular)
| |
1.29 |
118 |
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
BY-SA |
- Increase, Cytotoxicity (hepatocytes)
|
- Increase, hepatocellular adenomas and carcinomas
| |
1.29 |
119 |
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Increase, Adenomas/carcinomas (follicular cell)
| |
1.29 |
120 |
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) |
Charles Wood |
BY-SA |
- Inhibition, 5α-reductase activity
|
- Increase, Leydig cell tumors
| |
1.29 |
121 |
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) |
Charles Wood |
BY-SA |
- Increase, Urinary bladder calculi
|
- Increase, Adenomas/carcinomas (urothelial)
| |
1.29 |
122 |
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation |
Dalma Martinovic-Weigelt |
BY-SA |
- Inhibition, Prolyl hydroxylases
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
1.29 |
123 |
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription |
Dalma Martinovic-Weigelt |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
1.29 |
124 |
HMG-CoA reductase inhibition leading to decreased fertility |
Kellie Fay |
BY-SA |
- Inhibition, HMG-CoA reductase
|
| |
1.29 |
126 |
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation |
Tammy Stoker |
BY-SA |
- Inhibition, Antgonism of NE receptor
|
- Decreased, Decreased fecundity
| |
1.29 |
134 |
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Mary Gilbert |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Cognitive Function, Decreased
| |
1.29 |
138 |
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality |
Kellie Fay |
BY-SA |
- Inhibition, organic anion transporter 1 (OAT1)
|
- Increased Mortality
- Decrease, Population growth rate
| |
1.29 |
139 |
Alkylation of DNA leading to cancer 1 |
Carole Yauk |
Open for adoption |
|
| |
|
146 |
Estrogen Receptor Activation and Female Precocious Puberty |
Jeff Welch |
BY-SA |
|
| |
1.29 |
153 |
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats |
Tammy Stoker |
BY-SA |
- Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
|
- Decreased fertility, Reduced number of oocytes ovulated
| |
1.29 |
160 |
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality |
Knut Erik Tollefsen |
BY-SA |
- Activation, ionotropic GABA Receptor chloride channel
|
| |
|
161 |
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality |
Knut Erik Tollefsen |
BY-SA |
- Activation, Glutamate-gated chloride channels
|
| |
|
162 |
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse |
Charles Wood |
BY-SA |
|
- Increase, Adenomas/carcinomas (follicular cell)
| |
1.29 |
163 |
PPARgamma activation leading to sarcomas in rats, mice, and hamsters |
Charles Wood |
BY-SA |
- Activation of specific nuclear receptors, PPAR-gamma activation
|
| |
1.29 |
164 |
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse |
Charles Wood |
BY-SA |
- Activation, beta-2 adrenergic receptor
|
- Promotion, mesovarian leiomyomas
| |
1.29 |
165 |
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse |
Charles Wood |
BY-SA |
|
- Promotion, ovarian adenomas
- Promotion, ovarian granular cell tumors
| |
1.29 |
166 |
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse |
Charles Wood |
BY-SA |
|
- Increased, Pancreatic acinar tumors
| |
1.29 |
167 |
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. |
Charles Wood |
BY-SA |
- prepubertal increase, Estrogen receptor (ER) activity
|
- Increased, adenosquamous carcinomas of endometrium
| |
1.29 |
168 |
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. |
Charles Wood |
BY-SA |
|
- Increased, Adenomas/carcinomas (mammary)
| |
1.29 |
169 |
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. |
Charles Wood |
BY-SA |
|
- Increased, adenomas (pituitary)
| |
1.29 |
170 |
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat |
Charles Wood |
BY-SA |
|
- Increased, Adenomas/carcinomas (mammary)
| |
1.29 |
171 |
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. |
Charles Wood |
BY-SA |
|
| |
1.29 |
175 |
Thyroperoxidase inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Thyroperoxidase, Inhibition
|
- Altered, Amphibian metamorphosis
| |
1.29 |
176 |
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Inhibition, Na+/I- symporter (NIS)
|
- Altered, Amphibian metamorphosis
| |
1.29 |
177 |
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality |
Kellie Fay |
BY-SA |
- Inhibition, Cyclooxygenase 1 activity
|
- Increased Mortality
- Decrease, Population growth rate
| |
1.29 |
178 |
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure |
Carlie LaLone |
BY-SA |
- Activation, Nicotinic acetylcholine receptor
|
| |
1.29 |
179 |
Varroa mite infestation increases virus levels leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
180 |
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
181 |
Weather event contributes to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
182 |
Weather event contributes abnormal foraging leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
183 |
Nosema infection increases energetic demands leading to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
184 |
Nosema infection causes abnormal role change that leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
185 |
Queen egg-laying decrease leads to colony loss/failure |
Carlie LaLone |
BY-SA |
|
| |
1.29 |
186 |
unknown MIE leading to renal failure and mortality |
Kellie Fay |
BY-SA |
|
| |
1.29 |
188 |
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Inhibition, Iodotyrosine deiodinase (IYD)
|
- Altered, Amphibian metamorphosis
| |
1.29 |
189 |
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
190 |
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
191 |
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
192 |
Pendrin inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
193 |
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
|
- Altered, Amphibian metamorphosis
| |
1.29 |
194 |
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis |
Jonathan Haselman |
BY-SA |
- Activation, Hepatic nuclear receptor(s)
|
- Altered, Amphibian metamorphosis
| |
1.29 |
195 |
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
| |
1.29 |
196 |
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation |
Jeanelle Martinez |
BY-SA |
- TRPA1 activation, TRPA1 Receptor
|
- Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
- Irritation of nasal mucosa inducing sneeze reflex
- Increased Respiratory irritability and Chronic Cough,
| |
|
197 |
Sodium channel (Nav1.1) inhibition leading to population decline |
Kellie Fay |
BY-SA |
- Inhibition, sodium channel
|
| |
1.29 |
199 |
ER mediated breast cancer AOP |
Molly M Morgan |
BY-SA |
|
| |
|
200 |
Estrogen receptor activation leading to breast cancer |
Molly M Morgan |
Open for adoption |
- Activation, Estrogen receptor
|
| |
|
201 |
Juvenile hormone receptor agonism leading to male offspring induction associated population decline |
Knut Erik Tollefsen |
BY-SA |
- Activation, Juvenile hormone receptor
|
- Increased, Male offspring
- Decline, Population
- Alteration, Food-web structures
| |
|
203 |
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Decreased, Reproductive Success
- Decrease, Population growth rate
| |
1.29 |
204 |
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase |
Kellie Fay |
BY-SA |
- Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
|
- Increased, Reproductive Success
- Increased, Population
| |
1.29 |
205 |
AOP from chemical insult to cell death |
Mathieu Vinken |
BY-SA |
- Decompartmentalization
- Direct mitochondrial inhibition
- narcosis
|
| |
|
207 |
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans |
Jinhee Choi |
All rights reserved |
- Activation, NADPH Oxidase
|
| |
|
208 |
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure |
Jinhee Choi |
All rights reserved |
|
| |
|
209 |
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP |
Jinhee Choi |
All rights reserved |
|
| |
|
210 |
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building |
Jinhee Choi |
All rights reserved |
|
| |
|
211 |
Handbook development AOP |
Dan Villeneuve |
BY-SA |
|
| |
1.29 |
213 |
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) |
Lyle Burgoon |
Open for adoption |
- Inhibition, Fatty Acid Beta Oxidation
|
| |
|
214 |
Network of SSRIs (selective serotonin reuptake inhibitors) |
Lyle Burgoon |
Open for adoption |
|
- Increased, seizure
- Increased, agitation
- Increased, depression
- Increase, hypertension
| |
|
215 |
Molecular events lead to epilepsy |
Lyle Burgoon |
Open for adoption |
|
- Increase, seizure
- Increased, hippocampal hyperdepolarization
- Increased, epilepsy
| |
|
216 |
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia |
Knut Erik Tollefsen |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
|
217 |
Gastric ulcer formation |
Lyle Burgoon |
Open for adoption |
|
- Inhibit, gastric ulcer formation
- Activated, gastric ulcer formation
| |
|
218 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity |
Florence Pagé-Larivière |
BY-SA |
- CYP7B activity, inhibition
|
- Decrease, Population growth rate
| |
|
219 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior |
Florence Pagé-Larivière |
BY-SA |
- CYP7B activity, inhibition
|
- Decrease, Population growth rate
| |
|
221 |
Mental stress to depression |
Lyle Burgoon |
Open for adoption |
- Increased, glucocorticoid receptor activity
|
| |
|
222 |
Mental stress to agitation |
Lyle Burgoon |
Open for adoption |
- Increased, glucocorticoid receptor activity
|
| |
|
223 |
Serotonin transporter activation to seizure |
Lyle Burgoon |
Open for adoption |
- Increased, serotonin transporter activity
|
| |
|
224 |
Serotonin transporter activation to depression |
Lyle Burgoon |
Open for adoption |
- Increased, serotonin transporter activity
|
| |
|
225 |
Serotonin transporter activation to agitation |
Lyle Burgoon |
Open for adoption |
|
| |
|
226 |
SSRI (Selective serotonin reuptake inhibitor) to hypertension |
Lyle Burgoon |
Open for adoption |
- Decreased, serotonin transporter activity
|
| |
|
227 |
NSAID induced PTGS1 inactivation to gastric ulcer |
Lyle Burgoon |
Open for adoption |
|
- Activated, gastric ulcer formation
| |
|
228 |
NSAID induced PTGS2 inactivation to gastric ulcer |
Lyle Burgoon |
Open for adoption |
|
- Activated, gastric ulcer formation
| |
|
229 |
Helicobacter pylori to gastric ulcer |
Lyle Burgoon |
Open for adoption |
- Helicobacter pylori infection
|
- Activated, gastric ulcer formation
| |
|
230 |
presynaptic neuron 1 activation to epilepsy |
Lyle Burgoon |
Open for adoption |
- Activated, presynaptic neuron 1
|
| |
|
231 |
presynaptic neuron 2 repression to epilepsy |
Lyle Burgoon |
Open for adoption |
- Reduced, presynaptic neuron 2 activity
|
| |
|
232 |
NFE2/Nrf2 repression to steatosis |
Lyle Burgoon |
Open for adoption |
|
| |
|
233 |
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening |
Timothy Allen |
BY-SA |
- Mu Opioid Receptor Agonism
|
| |
|
234 |
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition |
Timothy Allen |
BY-SA |
- Mu Opioid Receptor Agonism
|
| |
|
235 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening |
Timothy Allen |
BY-SA |
- Serotonin 1A Receptor Agonism
|
| |
|
236 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition |
Timothy Allen |
BY-SA |
- Serotonin 1A Receptor Agonism
|
| |
|
239 |
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling |
Annie Jarabek |
BY-SA |
|
| |
|
240 |
DNA Adducts Leading to Liver Hemangiosarcoma |
Annie Jarabek |
BY-SA |
|
| |
|
286 |
Mitochondrial complex III antagonism leading to growth inhibition (1) |
You Song |
BY-SA |
- Increase, Mitochondrial complex III antagonism
|
| |
|
287 |
Mitochondrial complex III antagonism leading to growth inhibition (2) |
You Song |
BY-SA |
- Increase, Mitochondrial complex III antagonism
|
| |
|
290 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) |
You Song |
BY-SA |
- Increase, Mitochondrial ATP synthase antagonism
|
| |
|
291 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) |
You Song |
BY-SA |
- Increase, Mitochondrial ATP synthase antagonism
|
| |
|
299 |
Deposition of energy leading to population decline via DNA oxidation and follicular atresia |
You Song |
BY-SA |
|
- Reduction, Cumulative fecundity and spawning
- Decrease, Population growth rate
| |
|
336 |
DNA methyltransferase inhibition leading to population decline (1) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
| |
|
337 |
DNA methyltransferase inhibition leading to population decline (2) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
| |
|
339 |
DNA methyltransferase inhibition leading to population decline (4) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity
- Decrease, Population growth rate
| |
|
340 |
DNA methyltransferase inhibition leading to transgenerational effects (1) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity (F3)
- Decrease, Population growth rate
| |
|
341 |
DNA methyltransferase inhibition leading to transgenerational effects (2) |
You Song |
BY-SA |
- Increase, DNA methyltransferase inhibition
|
- Decrease, Fecundity (F3)
- Decrease, Population growth rate
| |
|