API
With OECD status With SAAOP status Recent AOPs

AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired TFHA/WNT Endorsed 1.33
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen Open for citation & comment Under Development EcR mortality
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for citation & comment Included in OECD Work Plan PPAR starvation-like body-weight loss TFHA/WNT Endorsed 2.3
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong Open for citation & comment Included in OECD Work Plan GABA epileptic seizures TFHA/WNT Endorsed 1.15
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration TFHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
21 Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker Open for citation & comment Included in OECD Work Plan AhR embryo toxicity TFHA/WNT Endorsed 1.27
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction TFHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Sharon Munn Open for citation & comment Included in OECD Work Plan Covalent Binding, Protein sensitisation, skin TFHA/WNT Endorsed 1.1
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes TFHA/WNT Endorsed 1.10
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for citation & comment Included in OECD Work Plan NIS learning and memory deficits in children TFHA/WNT Endorsed 1.28
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti Open for citation & comment Included in OECD Work Plan tubulin? aneuploid offspring EAGMST Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.17
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for citation & comment Included in OECD Work Plan AhR uroporphyria TFHA/WNT Endorsed 1.7
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Open for citation & comment Included in OECD Work Plan Activation, AhR Increase, Early Life Stage Mortality TFHA/WNT Endorsed 1.7
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe Open for citation & comment Included in OECD Work Plan Histone deacetylase, inhibition testicular toxicity EAGMST Under Review 1.52
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster Open for citation & comment Included in OECD Work Plan Activation of Cyp2E1 liver cancer EAGMST Under Review 1.24
277 Impaired IL-1R1 signaling leading to increased susceptibility to infection Yutaka Kimura Open for citation & comment Included in OECD Work Plan EAGMST Under Review 1.48
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET Open for citation & comment
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim Open for citation & comment Included in OECD Work Plan Under Development 1.81
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim Open for citation & comment Included in OECD Work Plan Under Development 1.78
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone Open for comment. Do not cite GR increased disease susceptibility 1.29
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development metabolic stress is not MIE colony loss/failure 1.29
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development unk colony loss/failure 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development glucose oxidase colony loss/failure 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Takumi Ohishi Open for comment. Do not cite Included in OECD Work Plan Calcineurin Activity, Inhibition EAGMST Under Review 1.38
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
205 AOP from chemical insult to cell death Mathieu Vinken Open for comment. Do not cite Under Development
263 Uncoupling of oxidative phosphorylation leading to growth inhibition (1) You Song Open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park Open for comment. Do not cite Included in OECD Work Plan Under Development 1.59
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.76
298 Chronic reactive oxygen species leading to human treatment-resistant gastric cancer Shihori Tanabe Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.58
319 Inhibition of Angiotensin-converting enzyme 2 leading to lung fibrosis Young Jun Kim Open for comment. Do not cite
320 Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim Open for comment. Do not cite
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid Open for comment. Do not cite
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption Under Development AR adverse effects in the male foetus
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption Under Development unclear energy imbalance
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Open for adoption Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption Under Development 5-HTT2c kidney toxicity
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption Under Development DNA alkylation cancer
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen Open for adoption Included in OECD Work Plan EAGMST Under Review 1.35
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption Under Development
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption Under Development
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption Under Development
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption Under Development
217 Gastric ulcer formation Lyle Burgoon Open for adoption Under Development
221 Mental stress to depression Lyle Burgoon Open for adoption Under Development
222 Mental stress to agitation Lyle Burgoon Open for adoption Under Development
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption Under Development
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption Under Development
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption Under Development
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption Under Development
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption Under Development
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption Under Development
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption Under Development
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption Under Development
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption Under Development
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption Under Development
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Not under active development Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Not under active development Included in OECD Work Plan case study Under Development 2.5
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry Not under active development Under Development nitric oxide liver tumors
34 LXR activation leading to hepatic steatosis Marina Goumenou Not under active development Under Development LXR liver steatosis
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Not under active development Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Not under active development Included in OECD Work Plan Under Development 1.50
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Not under active development Included in OECD Work Plan Under Development 1.31
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière Not under active development Under Development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière Not under active development Under Development
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen Not under active development Under Development
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen Not under active development Under Development
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen Not under active development Under Development
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen Not under active development Under Development
258 Renal protein alkylation leading to kidney toxicity Angela Mally Not under active development Included in OECD Work Plan Under Development 1.43
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration EAGMST Under Review 1.13
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
37 PPARα activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
128 Kidney dysfunction by decreased thyroid hormone Jung-Hwa Oh Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation EAGMST Under Review 1.47
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
151 AhR activation leading to preeclampsia Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
173 Substance interaction with the lung resident cell membrane components leading to lung fibrosis Sabina Halappanavar Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.32
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez Under development: Not open for comment. Do not cite Under Development
199 ER mediated breast cancer AOP Molly M Morgan Under development: Not open for comment. Do not cite Under Development
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.54
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi Under development: Not open for comment. Do not cite Under Development
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi Under development: Not open for comment. Do not cite Under Development
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi Under development: Not open for comment. Do not cite Under Development
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi Under development: Not open for comment. Do not cite Under Development
216 Excessive reactive oxygen species production leading to population decline via follicular atresia Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.55
238 Excessive reactive oxygen species production leading to population decline via lipid peroxidation Knut Erik Tollefsen Under development: Not open for comment. Do not cite
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek Under development: Not open for comment. Do not cite Under Development
240 DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek Under development: Not open for comment. Do not cite Under Development
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens Under development: Not open for comment. Do not cite
245 Reduction in photophosphorylation leading to growth inhibition in aquatic plants Knut Erik Tollefsen Under development: Not open for comment. Do not cite
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.43
259 Sensitization induction of the intestinal tract by food proteins Erwin Roggen Under development: Not open for comment. Do not cite
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders Under development: Not open for comment. Do not cite
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
264 Uncoupling of oxidative phosphorylation leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition (3) You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition (4) You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition (5) You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition (6) You Song Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.92
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild Under development: Not open for comment. Do not cite
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild Under development: Not open for comment. Do not cite
272 Direct deposition of ionizing energy leading to lung cancer Vinita Chauhan Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.56
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel Under development: Not open for comment. Do not cite
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens Under development: Not open for comment. Do not cite
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens Under development: Not open for comment. Do not cite
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens Under development: Not open for comment. Do not cite
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek Under development: Not open for comment. Do not cite
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens Under development: Not open for comment. Do not cite
280 α-diketone-induced bronchiolitis obliterans Marvin Martens Under development: Not open for comment. Do not cite
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Karen Watanabe Under development: Not open for comment. Do not cite
282 Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Satomi Onoue Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.49
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.45
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois Under development: Not open for comment. Do not cite
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens Under development: Not open for comment. Do not cite
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite Under Development
287 Mitochondrial complex III antagonism leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite Under Development
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite Under Development
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite Under Development
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.79
299 Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation You Song Under development: Not open for comment. Do not cite Under Development
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Under development: Not open for comment. Do not cite Included in OECD Work Plan Thyroid Receptor Antagonism Cognitve function, Decreased Under Development 1.84
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim Under development: Not open for comment. Do not cite
302 Lung surfactant function inhibition leading to impaired lung function Jorid Birkelund Sørli Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Carole Seidel Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.86
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee Under development: Not open for comment. Do not cite
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.90
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering Under development: Not open for comment. Do not cite
311 Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction You Song Under development: Not open for comment. Do not cite
312 Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​ Kristie Sullivan Under development: Not open for comment. Do not cite
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.74
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.60
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker Under development: Not open for comment. Do not cite
322 Alkylation of DNA leading to reduced sperm count Carole Yauk Under development: Not open for comment. Do not cite
323 PPARalpha Agonism Impairs Fish Reproduction Ashley Kittelson Under development: Not open for comment. Do not cite
324 Thermal stress leading to population decline (1) You Song Under development: Not open for comment. Do not cite
325 Thermal stress leading to population decline (2) You Song Under development: Not open for comment. Do not cite
326 Thermal stress leading to population decline (3) You Song Under development: Not open for comment. Do not cite
327 Excessive reactive oxygen species production leading to mortality (1) You Song Under development: Not open for comment. Do not cite
328 Excessive reactive oxygen species production leading to mortality (2) You Song Under development: Not open for comment. Do not cite
329 Excessive reactive oxygen species production leading to mortality (3) You Song Under development: Not open for comment. Do not cite
330 Excessive reactive oxygen species production leading to mortality (4) You Song Under development: Not open for comment. Do not cite
331 Formation of DNA photoproducts leading to growth inhibition (1) You Song Under development: Not open for comment. Do not cite
332 Formation of DNA photoproducts leading to growth inhibition (2) You Song Under development: Not open for comment. Do not cite
333 Formation of DNA photoproducts leading to growth inhibition (3) You Song Under development: Not open for comment. Do not cite
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole Under development: Not open for comment. Do not cite
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza Under development: Not open for comment. Do not cite
342 S-adenosylmethionine depletion leading to population decline (1) You Song Under development: Not open for comment. Do not cite
343 S-adenosylmethionine depletion leading to population decline (2) You Song Under development: Not open for comment. Do not cite
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen Under development: Not open for comment. Do not cite
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen Under development: Not open for comment. Do not cite
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon Under development: Not open for comment. Do not cite
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased trajectory in fish Young Jun Kim Under development: Not open for comment. Do not cite
349 Inhibition of 11β-hydroxylase leading to decresed trajectory in fish Young Jun Kim Under development: Not open for comment. Do not cite
358 Chitinase inhibition leading to mortality Simon Schmid Under development: Not open for comment. Do not cite
359 Chitobiase inhibition leading to mortality Simon Schmid Under development: Not open for comment. Do not cite
361 Sulfonylureareceptor binding leading to mortality Simon Schmid Under development: Not open for comment. Do not cite
362 Immune mediated hepatitis Jung-Hwa Oh Under development: Not open for comment. Do not cite
363 Thyroperoxidase inhibition leading to increased mortality via altered eye structure Lucia Vergauwen Under development: Not open for comment. Do not cite
364 Thyroperoxidase inhibition leading to increased mortality via decreased eye size Lucia Vergauwen Under development: Not open for comment. Do not cite
365 Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning Lucia Vergauwen Under development: Not open for comment. Do not cite
366 Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite
367 Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite
368 Cytochrome oxidase inhibition leading to olfactory nasal lesions Katy Goyak Under development: Not open for comment. Do not cite
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song Under development: Not open for comment. Do not cite
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song Under development: Not open for comment. Do not cite
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song Under development: Not open for comment. Do not cite
372 Androgen receptor antagonism leading to testicular cancer Chander K. Negi Under development: Not open for comment. Do not cite
374 Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis Anna Price Under development: Not open for comment. Do not cite
375 test AOP Kevin Crofton Under development: Not open for comment. Do not cite
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve Under development: Not open for comment. Do not cite
377 Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD) Gillina Bezemer Under development: Not open for comment. Do not cite
378 Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load Gillina Bezemer Under development: Not open for comment. Do not cite
379 Increased susceptibility to viral entry and coronavirus production leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe Under development: Not open for comment. Do not cite
381 Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia Young Jun Kim Under development: Not open for comment. Do not cite
382 Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis Young Jun Kim Under development: Not open for comment. Do not cite
383 Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis Young Jun Kim Under development: Not open for comment. Do not cite
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim Under development: Not open for comment. Do not cite
385 ACE2 dysregulation leading to microvascular disfunction Julija Filipovska Under development: Not open for comment. Do not cite
386 Increased reactive oxygen species production leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen Under development: Not open for comment. Do not cite
387 Increased reactive oxygen species production leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen Under development: Not open for comment. Do not cite
388 DNA damage leading to population decline via programmed cell death Knut Erik Tollefsen Under development: Not open for comment. Do not cite
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen Under development: Not open for comment. Do not cite
392 Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation Penny Nymark Under development: Not open for comment. Do not cite
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under Development: Contributions and Comments Welcome Included in OECD Work Plan AChE acute mortality Under Development 1.3
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive failure 1.29
29 Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development ER reproductive dysfunction 1.29
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development b-oxidation fatty acid steatosis 1.29
39 Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract Kristie Sullivan Under Development: Contributions and Comments Welcome Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development ER altered sexual differentiation 1.29
53 ER agonism leading to reduced survival due to renal failure Tom Hutchinson Under Development: Contributions and Comments Welcome Under Development ER reduced survival 1.29
57 AhR activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development AhR hepatic steatosis 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development CAR hepatic steatosis 1.29
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development HNF4alpha hepatic steatosis 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development PXR hepatic steatosis 1.29
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development multiple hepatic steatosis 1.29
62 AKT2 activation leading to hepatic steatosis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development AKT2 hepatic steatosis 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws Under Development: Contributions and Comments Welcome Under Development GR decreased male fertitlity 1.29
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development GR modulation of leydig cell function 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development estradiol modulation of leydig cell function 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development proteins - undefined modulation of leydig cell function 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development multiple modulation of leydig cell function 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development modulation of leydig cell function 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development GR modulation of leydig cell function 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish Under Development: Contributions and Comments Welcome Under Development PPARg adipogenesis 1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker Under Development: Contributions and Comments Welcome Under Development DBH reduced fecundity 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter Under Development: Contributions and Comments Welcome Under Development unk modulation of leydig cell function 1.29
91 Sodium channel inhibition leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development sodium channel reduced survival 1.29
93 sodium channel inhibition leading to increased predation Kellie Fay Under Development: Contributions and Comments Welcome Under Development sodium channel increased predation 1.29
94 Sodium channel inhibition leading to congenital malformations Kellie Fay Under Development: Contributions and Comments Welcome Under Development sodium channel congenital malformations 1.29
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development ERG reduced survival 1.29
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development sodium channel acute mortality 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development 5-HTT increased predation 1.29
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh Under Development: Contributions and Comments Welcome 5-HTT increased predation 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay Under Development: Contributions and Comments Welcome Under Development H2 reduced survival 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development cyclooxygenase reproductive dysfunction 1.29
104 Altered ion channel activity leading impaired heart function Kevin Dreher Under Development: Contributions and Comments Welcome Under Development multiple impaired heart function 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development Alpha2u adenomas and carcinomas 1.29
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development pyruvate dehydrogenase hepatocellular carcinoma 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE bronchioloalveolar adenomas and carcinomas 1.29
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development NIS follicular cell adenomas and carcinomas 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development AR leydig cell tumors 1.29
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development dopamine?? endometrial adenocarcinomas 1.29
113 Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development GluCl Channel acute mortality 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development HPPD corneal papillomas and carcinomas 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development cytotox not MIE forestomach tumors 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE renal tubular adenomas and carcinomas 1.29
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development cytotox is not MIE hepatocellular adenomas and carcinomas 1.29
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under Development: Contributions and Comments Welcome Under Development TPO follicular cell adenomas and carcinomas 1.29
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development 5α-reductase leydig cell tumors 1.29
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood Under Development: Contributions and Comments Welcome Under Development unclear urothelial papillomas and carcinomas 1.29
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development Prolyl hydroxylase reproductive dysfunction 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Under Development: Contributions and Comments Welcome Under Development Unknown reproductive dysfunction 1.29
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay Under Development: Contributions and Comments Welcome Under Development HMG-CoA reductase decreased fertility 1.29
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker Under Development: Contributions and Comments Welcome Under Development alpha Norad Receptors delayed ovulation 1.29
130 Phospholipase A inhibitors lead to hepatotoxicity Jung-Hwa Oh Under Development: Contributions and Comments Welcome Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert Under Development: Contributions and Comments Welcome Under Development NIS neurodevelopmental outcomes 1.29
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development p-amino hippuric acid renal failure and mortality 1.29
146 Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch Under Development: Contributions and Comments Welcome Under Development ER 1.29
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Kristie Sullivan Under Development: Contributions and Comments Welcome Included in OECD Work Plan Transthyretin Under Development 1.41
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker Under Development: Contributions and Comments Welcome Under Development 1.29
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood Under Development: Contributions and Comments Welcome Under Development 1.29
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
181 Weather event contributes to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone Under Development: Contributions and Comments Welcome Under Development 1.29
186 unknown MIE leading to renal failure and mortality Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1.29
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman Under Development: Contributions and Comments Welcome Under Development 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1.29
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1.29
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay Under Development: Contributions and Comments Welcome Under Development 1.29
211 Handbook development AOP Dan Villeneuve Under Development: Contributions and Comments Welcome Under Development 1.29
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim Under Development: Contributions and Comments Welcome Included in OECD Work Plan Under Development 1.77
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim Under Development: Contributions and Comments Welcome
318 Glucocorticoid Receptor activation leading to hepatic steatosis Chander K. Negi Under Development: Contributions and Comments Welcome
336 DNA methyltransferase inhibition leading to population decline (1) You Song Under Development: Contributions and Comments Welcome Under Development
337 DNA methyltransferase inhibition leading to population decline (2) You Song Under Development: Contributions and Comments Welcome Under Development
338 DNA methyltransferase inhibition leading to population decline (3) You Song Under Development: Contributions and Comments Welcome
339 DNA methyltransferase inhibition leading to population decline (4) You Song Under Development: Contributions and Comments Welcome Under Development
340 DNA methyltransferase inhibition leading to transgenerational effects (1) You Song Under Development: Contributions and Comments Welcome Under Development
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song Under Development: Contributions and Comments Welcome Under Development
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez Under Development: Contributions and Comments Welcome
373 Mitochondrial dysfunction to metabolic diseases Chander K. Negi Under Development: Contributions and Comments Welcome