API
With OECD status With SAAOP status Recent AOPs

AOPs

Id Title Point of Contact Author Status SAAOP Status MIE AO OECD Status OECD Project
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron Open for citation & comment Included in OECD Work Plan NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor Motor function, impaired TFHA/WNT Endorsed 1.33
4 Ecdysone receptor agonism leading to incomplete ecdysis associated mortality Knut Erik Tollefsen Open for citation & comment Under Development EcR mortality
7 Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
12 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging Florianne Tschudi-Monnet Open for citation & comment Included in OECD Work Plan NMDAR neuroinflammation and lead to neurodegeneration TFHA/WNT Endorsed 1.13
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price Open for citation & comment Included in OECD Work Plan NMDAR impairment of learning and memory abilities TFHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk Open for citation & comment Included in OECD Work Plan DNA alkylation heritable mutations TFHA/WNT Endorsed 1.11
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard Open for citation & comment Included in OECD Work Plan PPAR impaired fertility EAGMST Under Review 1.21
23 Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) Dan Villeneuve Open for citation & comment Included in OECD Work Plan AR reproductive dysfunction TFHA/WNT Endorsed 1.12
25 Aromatase inhibition leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan Aromatate Inhib reproductive dysfunction TFHA/WNT Endorsed 1.12
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve Open for citation & comment Included in OECD Work Plan ER reproductive dysfunction EAGMST Under Review 1.12
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann Open for citation & comment Included in OECD Work Plan Protein alkylation liver fibrosis TFHA/WNT Endorsed 1.14
40 Covalent Protein binding leading to Skin Sensitisation Sharon Munn Open for citation & comment Included in OECD Work Plan Covalent Binding, Protein sensitisation, skin TFHA/WNT Endorsed 1.1
41 Sustained AhR Activation leading to Rodent Liver Tumours Rick Becker Open for citation & comment Included in OECD Work Plan AhR liver tumors EAGMST Under Review 1.7
42 Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Open for citation & comment Included in OECD Work Plan TPO neurodevelopmental outcomes EAGMST Approved 1.10
43 Disruption of VEGFR Signaling Leading to Developmental Defects Tom Knudsen Open for citation & comment Included in OECD Work Plan VEGF developmental outcomes EAGMST Under Review 1.6
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon Open for citation & comment Included in OECD Work Plan AFB1 hepatocellular carcinoma EAGMST Under Review 1.8
48 Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. Anna Price Open for citation & comment Included in OECD Work Plan Glutamate Receptor learning and memory impairment. TFHA/WNT Endorsed 1.23
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price Open for citation & comment Included in OECD Work Plan NIS learning and memory deficits in children EAGMST Approved 1.28
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser Open for citation & comment Included in OECD Work Plan CAR hepatocellular adenomas and carcinomas EAGMST Under Review 1.18
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Justin Teeguarden Open for citation & comment Included in OECD Work Plan unclear contact nasal tumors EAGMST Under Review 2.7
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster Open for citation & comment Included in OECD Work Plan Activation of Cyp2E1 liver cancer EAGMST Under Review 1.24
6 Antagonist binding to PPARα leading to body-weight loss Kurt A. Gust Open for comment. Do not cite Included in OECD Work Plan PPAR starvation-like body-weight loss EAGMST Approved 2.3
10 Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain Ping Gong Open for comment. Do not cite Included in OECD Work Plan GABA epileptic seizures EAGMST Approved 1.15
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone Open for comment. Do not cite Under Development GR increased disease susceptibility 1.29
21 aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 Markus Hecker Open for comment. Do not cite Included in OECD Work Plan AhR embryo toxicity EAGMST Approved 1.27
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
78 Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
79 Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
80 Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
81 Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development metabolic stress is not MIE colony loss/failure 1.29
82 Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development unk colony loss/failure 1.29
84 Suppression of immune system contributes to impaired development and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
85 Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development unclear colony loss/failure 1.29
86 Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development glucose oxidase colony loss/failure 1.29
87 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
88 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
89 Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone Open for comment. Do not cite Under Development nAChR colony loss/failure 1.29
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat Open for comment. Do not cite Included in OECD Work Plan AhR uroporphyria EAGMST Approved 1.7
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat Open for comment. Do not cite Included in OECD Work Plan Activation, AhR Increase, Early Life Stage Mortality EAGMST Approved 1.7
154 Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response Kiyoshi Kushima Open for comment. Do not cite Included in OECD Work Plan Calcineurin Activity, Inhibition EAGMST Under Review 1.38
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron Open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.53
205 AOP from chemical insult to cell death Mathieu Vinken Open for comment. Do not cite Under Development
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Under development: Not open for comment. Do not cite Included in OECD Work Plan mulitple neurodevelopmental outcomes Under Development 1.9
11 Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol Jun Kanno Under development: Not open for comment. Do not cite Included in OECD Work Plan case study Under Development 2.5
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve Under development: Not open for comment. Do not cite Included in OECD Work Plan AChE acute mortality Under Development 1.3
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich Under development: Not open for comment. Do not cite Included in OECD Work Plan multiple neuroinflammation leading to neurodegeneration EAGMST Under Review 1.13
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Under development: Not open for comment. Do not cite Under Development AR adverse effects in the male foetus
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Under development: Not open for comment. Do not cite Under Development unclear energy imbalance
27 Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Mathieu Vinken Under development: Not open for comment. Do not cite Included in OECD Work Plan ABCB11 cholestatic liver injury Under Development 1.19
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive failure 1.29
29 Estrogen receptor agonism leading to reproductive dysfunction Tom Hutchinson Under development: Not open for comment. Do not cite Under Development ER reproductive dysfunction 1.29
31 Oxidation of iron in hemoglobin leading to hematotoxicity Mitchell S. Wilbanks Under development: Not open for comment. Do not cite Included in OECD Work Plan heme oxidation ? hematotoxicity Under Development 1.16
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Michelle Embry Under development: Not open for comment. Do not cite Under Development nitric oxide liver tumors
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Under development: Not open for comment. Do not cite Under Development 5-HTT2c kidney toxicity
34 LXR activation leading to hepatic steatosis Marina Goumenou Under development: Not open for comment. Do not cite Under Development LXR liver steatosis
35 Narcosis leading to respiratory failure Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan undefined sensitisation of the respiratory tract Under Development 1.2
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development b-oxidation fatty acid steatosis 1.29
37 PPARalpha-dependent liver cancer Chris Corton Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR alpha liver cancer Under Development 1.17
39 Sensitisation of the Respiratory Tract induced by Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins Kristie Sullivan Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear what proteins sensitisation of the respiratory tract Under Development 1.20
51 PPARα activation leading to impaired fertility in adult male rodents Elise Grignard Under development: Not open for comment. Do not cite Included in OECD Work Plan PPAR α impaired fertility Under Development 1.21
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Tom Hutchinson Under development: Not open for comment. Do not cite Under Development ER altered sexual differentiation 1.29
53 ER agonism leading to reduced survival due to renal failure Tom Hutchinson Under development: Not open for comment. Do not cite Under Development ER reduced survival 1.29
57 AhR activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development AhR hepatic steatosis 1.29
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development CAR hepatic steatosis 1.29
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development HNF4alpha hepatic steatosis 1.29
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development PXR hepatic steatosis 1.29
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development multiple hepatic steatosis 1.29
62 AKT2 activation leading to hepatic steatosis Michelle Angrish Under development: Not open for comment. Do not cite Under Development AKT2 hepatic steatosis 1.29
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Susan Laws Under development: Not open for comment. Do not cite Under Development GR decreased male fertitlity 1.29
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Under Development GR modulation of leydig cell function 1.29
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Under Development estradiol modulation of leydig cell function 1.29
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Gary Klinefelter Under development: Not open for comment. Do not cite Under Development proteins - undefined modulation of leydig cell function 1.29
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Gary Klinefelter Under development: Not open for comment. Do not cite Under Development multiple modulation of leydig cell function 1.29
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Gary Klinefelter Under development: Not open for comment. Do not cite Under Development modulation of leydig cell function 1.29
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Gary Klinefelter Under development: Not open for comment. Do not cite Under Development GR modulation of leydig cell function 1.29
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish Under development: Not open for comment. Do not cite Under Development PPARg adipogenesis 1.29
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Tammy Stoker Under development: Not open for comment. Do not cite Under Development DBH reduced fecundity 1.29
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Gary Klinefelter Under development: Not open for comment. Do not cite Under Development unk modulation of leydig cell function 1.29
91 Sodium channel inhibition leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel reduced survival 1.29
93 sodium channel inhibition leading to increased predation Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel increased predation 1.29
94 Sodium channel inhibition leading to congenital malformations Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel congenital malformations 1.29
95 Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Under Development ERG reduced survival 1.29
96 Axonal sodium channel modulation leading to acute mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development sodium channel acute mortality 1.29
97 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Kellie Fay Under development: Not open for comment. Do not cite Under Development 5-HTT increased predation 1.29
98 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation Ksenia Groh Under development: Not open for comment. Do not cite Under Development 5-HTT increased predation 1.29
99 Histamine (H2) receptor antagonism leading to reduced survival Kellie Fay Under development: Not open for comment. Do not cite Under Development H2 reduced survival 1.29
100 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
101 Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
102 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
103 Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development cyclooxygenase reproductive dysfunction 1.29
104 Altered ion channel activity leading impaired heart function Kevin Dreher Under development: Not open for comment. Do not cite Under Development multiple impaired heart function 1.29
105 Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under development: Not open for comment. Do not cite Under Development Alpha2u adenomas and carcinomas 1.29
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti Under development: Not open for comment. Do not cite Under Development tubulin? aneuploid offspring
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development pyruvate dehydrogenase hepatocellular carcinoma 1.29
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox is not MIE bronchioloalveolar adenomas and carcinomas 1.29
110 Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under development: Not open for comment. Do not cite Under Development NIS follicular cell adenomas and carcinomas 1.29
111 Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) Charles Wood Under development: Not open for comment. Do not cite Under Development AR leydig cell tumors 1.29
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood Under development: Not open for comment. Do not cite Under Development dopamine?? endometrial adenocarcinomas 1.29
113 Glutamate-gated chloride channel activation leading to acute mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development GluCl Channel acute mortality 1.29
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood Under development: Not open for comment. Do not cite Under Development HPPD corneal papillomas and carcinomas 1.29
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox not MIE forestomach tumors 1.29
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox is not MIE renal tubular adenomas and carcinomas 1.29
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Included in OECD Work Plan AR adenomas and carcinomas Under Development 1.26
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development cytotox is not MIE hepatocellular adenomas and carcinomas 1.29
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood Under development: Not open for comment. Do not cite Under Development TPO follicular cell adenomas and carcinomas 1.29
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood Under development: Not open for comment. Do not cite Under Development 5α-reductase leydig cell tumors 1.29
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood Under development: Not open for comment. Do not cite Under Development unclear urothelial papillomas and carcinomas 1.29
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development Prolyl hydroxylase reproductive dysfunction 1.29
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt Under development: Not open for comment. Do not cite Under Development Unknown reproductive dysfunction 1.29
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay Under development: Not open for comment. Do not cite Under Development HMG-CoA reductase decreased fertility 1.29
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Tammy Stoker Under development: Not open for comment. Do not cite Under Development alpha Norad Receptors delayed ovulation 1.29
128 Kidney dysfunction by decreased thyroid hormone Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan unclear - KE as MIE? kidnney dysfunction Under Development 1.40
130 Phospholipase A inhibitors lead to hepatotoxicity Seokjoo Yoon Under development: Not open for comment. Do not cite Included in OECD Work Plan phospolipase A hepatotoxicity Under Development 1.39
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert Under development: Not open for comment. Do not cite Under Development NIS neurodevelopmental outcomes 1.29
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development p-amino hippuric acid renal failure and mortality 1.29
139 Alkylation of DNA leading to cancer 1 Carole Yauk Under development: Not open for comment. Do not cite Under Development DNA alkylation cancer
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic Under development: Not open for comment. Do not cite Included in OECD Work Plan Liver, Inflammation Under Development 1.47
146 Estrogen Receptor Activation and Female Precocious Puberty Jeff Welch Under development: Not open for comment. Do not cite Under Development ER 1.29
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich Under development: Not open for comment. Do not cite Included in OECD Work Plan EGFR Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Frazer Lowe Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.50
151 AhR signalling leading to placental vascular disruption Sabrina Tait Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.42
152 Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity Erik Janus Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.41
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Tammy Stoker Under development: Not open for comment. Do not cite Under Development 1.29
155 Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
156 Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
157 Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
158 Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
159 Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation Dries Knapen Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.35
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
164 Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
165 Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
166 PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
167 Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood Under development: Not open for comment. Do not cite Under Development 1.29
173 Increased substance interaction with the resident cell membrane components leading to lung fibrosis Sabina Halappanavar Under development: Not open for comment. Do not cite Included in OECD Work Plan EAGMST Under Review 1.32
175 Thyroperoxidase inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
181 Weather event contributes to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone Under development: Not open for comment. Do not cite Under Development 1.29
186 unknown MIE leading to renal failure and mortality Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
187 Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage Barnett Rattner Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.31
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman Under development: Not open for comment. Do not cite Under Development 1.29
195 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
196 Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation Jeanelle Martinez Under development: Not open for comment. Do not cite Under Development
197 Sodium channel (Nav1.1) inhibition leading to population decline Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
199 ER mediated breast cancer AOP Molly M Morgan Under development: Not open for comment. Do not cite Under Development
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Under development: Not open for comment. Do not cite Under Development
201 Juvenile hormone receptor agonism leading to male offspring induction associated population decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
203 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
204 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase Kellie Fay Under development: Not open for comment. Do not cite Under Development 1.29
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi Under development: Not open for comment. Do not cite Included in OECD Work Plan Under Development 1.54
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi Under development: Not open for comment. Do not cite Under Development
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi Under development: Not open for comment. Do not cite Under Development
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi Under development: Not open for comment. Do not cite Under Development
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi Under development: Not open for comment. Do not cite Under Development
211 Handbook development AOP Dan Villeneuve Under development: Not open for comment. Do not cite Under Development 1.29
212 Histone deacetylase inhibition leading to testicular toxicity Shihori Tanabe Under development: Not open for comment. Do not cite Included in OECD Work Plan Histone deacetylase, inhibition testicular toxicity EAGMST Under Review 1.52
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
215 Molecular events lead to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
216 Excessive reactive oxygen species production leading to oocyte apoptosis-associated reproduction decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite Under Development
217 Gastric ulcer formation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière Under development: Not open for comment. Do not cite Under Development
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière Under development: Not open for comment. Do not cite Under Development
221 Mental stress to depression Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
222 Mental stress to agitation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
223 Serotonin transporter activation to seizure Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
224 Serotonin transporter activation to depression Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
225 Serotonin transporter activation to agitation Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Under development: Not open for comment. Do not cite Under Development
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen Under development: Not open for comment. Do not cite Under Development
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen Under development: Not open for comment. Do not cite Under Development
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen Under development: Not open for comment. Do not cite Under Development
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen Under development: Not open for comment. Do not cite Under Development
237 Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression Sarah Søs Poulsen Under development: Not open for comment. Do not cite
238 Excessive reactive oxygen species production leading to reduced ATP production-associated reproduction decline Knut Erik Tollefsen Under development: Not open for comment. Do not cite
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Annie Jarabek Under development: Not open for comment. Do not cite Under Development
240 DNA Adducts Leading to Liver Hemangiosarcoma Annie Jarabek Under development: Not open for comment. Do not cite Under Development
241 Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis Marvin Martens Under development: Not open for comment. Do not cite
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Under development: Not open for comment. Do not cite
245 Uncoupling of photophosphorylation leading to reduced ATP production associated growth inhibition Knut Erik Tollefsen Under development: Not open for comment. Do not cite
256 Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
257 Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
258 Renal protein alkylation leading to kidney toxicity Angela Mally Under development: Not open for comment. Do not cite
259 Sensitization induction of the intestinal tract by food proteins Erwin Roggen Under development: Not open for comment. Do not cite
260 CYP2E1 activation and formation of protein adducts leading to neurodegeneration Jelle Broeders Under development: Not open for comment. Do not cite
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite
263 Chitin synthase inhibition leading to premature molting associated mortality You Song Under development: Not open for comment. Do not cite
264 Sulfonylurea receptor binding leading to premature molting associated mortality You Song Under development: Not open for comment. Do not cite
265 D1 protein blockage leading to photosystem II (PSII)-inhibition associated growth reduction You Song Under development: Not open for comment. Do not cite
266 D1 protein blockage leading to apoptosis associated growth inhibition You Song Under development: Not open for comment. Do not cite
267 Uncoupling of oxidative phosphorylation leading to mortality You Song Under development: Not open for comment. Do not cite
268 Uncoupling of oxidative phosphorylation leading to reproduction decline You Song Under development: Not open for comment. Do not cite
269 Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development Christopher Goodchild Under development: Not open for comment. Do not cite
270 Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity Christopher Goodchild Under development: Not open for comment. Do not cite
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park Under development: Not open for comment. Do not cite
272 Direct deposition of ionizing energy onto DNA leading to lung cancer Vinita Chauhan Under development: Not open for comment. Do not cite
273 Mitochondrial complex inhibition leading to liver injury Wanda van der Stel Under development: Not open for comment. Do not cite
274 Histone deacetylase inhibition leads to impeded craniofacial development Marvin Martens Under development: Not open for comment. Do not cite
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens Under development: Not open for comment. Do not cite
276 Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome Marvin Martens Under development: Not open for comment. Do not cite
277 Inhibition of IL-1 signaling Yutaka Kimura Under development: Not open for comment. Do not cite
278 IKK complex inhibition leading to liver injury Nanette Vrijenhoek Under development: Not open for comment. Do not cite
279 Microtubule interacting drugs lead to peripheral neuropathy Marvin Martens Under development: Not open for comment. Do not cite
280 α-diketone-induced bronchiolitis obliterans Marvin Martens Under development: Not open for comment. Do not cite
281 Acetylcholinesterase Inhibition Leading to Neurodegeneration Kendra Conrow Under development: Not open for comment. Do not cite
282 Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions Satomi Onoue Under development: Not open for comment. Do not cite
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci Under development: Not open for comment. Do not cite
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois Under development: Not open for comment. Do not cite
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens Under development: Not open for comment. Do not cite
286 Mitochondrila Complex III inhibition leading to ATP depletion associated mortality You Song Under development: Not open for comment. Do not cite
287 Mitochondrila Complex III inhibition leading to oxidative stress associated mortality You Song Under development: Not open for comment. Do not cite
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET Under development: Not open for comment. Do not cite
289 Inhibition of 5α-reductase leading to impaired fertility in female fish Young Jun Kim Under development: Not open for comment. Do not cite
290 DNA methyltransferase inhibition leading to reduced fecundity associated population decline You Song Under development: Not open for comment. Do not cite
291 DNA methyltransferase inhibition leading to transgenerational DNA methylation associated population decline You Song Under development: Not open for comment. Do not cite
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim Under development: Not open for comment. Do not cite
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm Under development: Not open for comment. Do not cite
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman Under development: Not open for comment. Do not cite
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk Under development: Not open for comment. Do not cite
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim Under development: Not open for comment. Do not cite
298 Wnt ligand stimulation and Wnt signalling activation lead to cancer malignancy Shihori Tanabe Under development: Not open for comment. Do not cite
299 S-adenosylmethionine depletion leading to reduced fecundity You Song Under development: Not open for comment. Do not cite
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton Under development: Not open for comment. Do not cite
301 Inhibition of homocysteine clearance leading to neuronal dysfunctions Young Jun Kim Under development: Not open for comment. Do not cite