| 259 |
Sensitization induction of the intestinal tract by food proteins |
Erwin Roggen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 260 |
CYP2E1 activation and formation of protein adducts leading to neurodegeneration |
Jelle Broeders |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 269 |
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development |
Christopher Goodchild |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 270 |
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity |
Christopher Goodchild |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 273 |
Mitochondrial complex inhibition leading to liver injury |
Wanda van der Stel |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 274 |
Histone deacetylase inhibition leads to impeded craniofacial development |
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 275 |
Histone deacetylase inhibition leads to neural tube defects |
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 276 |
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome |
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 278 |
IKK complex inhibition leading to liver injury |
Nanette Vrijenhoek |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 279 |
Microtubule interacting drugs lead to peripheral neuropathy |
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 280 |
α-diketone-induced bronchiolitis obliterans |
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 281 |
Acetylcholinesterase Inhibition Leading to Neurodegeneration |
Karen Watanabe |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 284 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease |
Frederic Y. Bois |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 285 |
Inhibition of N-linked glycosylation leads to liver injury |
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 288 |
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) |
Bérénice COLLET |
Open for citation & comment |
|
|
|
|
|
| 301 |
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 304 |
TBX1 inhibition leading to congenital cardiac conotruncal anomalies |
Jinsoo Lee |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 309 |
Luteinizing hormone receptor antagonism leading to reproductive dysfunction |
Young Jun Kim |
Under Development: Contributions and Comments Welcome |
|
|
|
|
|
| 310 |
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR |
Jon Doering |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 311 |
Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 312 |
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement |
Kristie Sullivan |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 318 |
Glucocorticoid Receptor activation leading to hepatic steatosis |
Chander K. Negi |
Under Development: Contributions and Comments Welcome |
|
|
|
|
|
| 319 |
ACE2 inhibition leading to lung fibrosis |
Young Jun Kim |
Open for comment. Do not cite |
|
|
|
|
|
| 320 |
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality |
Young Jun Kim |
Open for comment. Do not cite |
|
|
|
|
|
| 321 |
Reduced environmental pH leading to thinner shells in Mytilus edulis |
James Ducker |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 322 |
Alkylation of DNA leading to reduced sperm count |
Carole Yauk |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 323 |
PPARalpha Agonism Impairs Fish Reproduction |
Ashley Kittelson |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 324 |
Thermal stress leading to population decline (1) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 325 |
Thermal stress leading to population decline (2) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 326 |
Thermal stress leading to population decline (3) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 327 |
Excessive reactive oxygen species production leading to mortality (1) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 328 |
Excessive reactive oxygen species production leading to mortality (2) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 329 |
Excessive reactive oxygen species production leading to mortality (3) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 330 |
Excessive reactive oxygen species production leading to mortality (4) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 331 |
Formation of DNA photoproducts leading to growth inhibition (1) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 332 |
Formation of DNA photoproducts leading to growth inhibition (2) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 333 |
Formation of DNA photoproducts leading to growth inhibition (3) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 334 |
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration |
Alexander Cole |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 335 |
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment |
Nathalia Pereira Souza |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 338 |
DNA methyltransferase inhibition leading to population decline (3) |
You Song |
Under Development: Contributions and Comments Welcome |
|
|
|
|
|
| 342 |
S-adenosylmethionine depletion leading to population decline (1) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 343 |
S-adenosylmethionine depletion leading to population decline (2) |
You Song |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 344 |
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 345 |
Androgen receptor (AR) antagonism leading to decreased fertility in females |
Terje Svingen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 346 |
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation |
Kelvin Santana Rodriguez |
Under Development: Contributions and Comments Welcome |
|
|
|
|
|
| 347 |
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis |
Seokjoo Yoon |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 348 |
Inhibition of 11β-HSD leading to impaired spermatogenesis in fish |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 349 |
Inhibition of 11β-hydroxylase leading to male infertility in fish |
Young Jun Kim |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 358 |
Chitinase inhibition leading to mortality |
Simon Schmid |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 359 |
Chitobiase inhibition leading to mortality |
Simon Schmid |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 360 |
Chitin synthase 1 inhibition leading to mortality |
Simon Schmid |
Open for comment. Do not cite |
|
|
|
|
|
| 361 |
Sulfonylureareceptor binding leading to mortality |
Simon Schmid |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 362 |
Immune mediated hepatitis |
Jung-Hwa Oh |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 363 |
Thyroperoxidase inhibition leading to increased mortality via altered eye structure |
Lucia Vergauwen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 364 |
Thyroperoxidase inhibition leading to increased mortality via decreased eye size |
Lucia Vergauwen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 365 |
Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning |
Lucia Vergauwen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 366 |
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 367 |
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 203 |
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 204 |
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 205 |
AOP from chemical insult to cell death |
Mathieu Vinken |
Open for comment. Do not cite |
Under Development |
|
|
|
|
| 207 |
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans |
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 208 |
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure |
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 209 |
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP |
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 210 |
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building |
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 211 |
Handbook development AOP |
Dan Villeneuve |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 213 |
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 214 |
Network of SSRIs (selective serotonin reuptake inhibitors) |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 215 |
Molecular events lead to epilepsy |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 216 |
Excessive reactive oxygen species production leading to population decline via follicular atresia |
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 217 |
Gastric ulcer formation |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 218 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity |
Florence Pagé-Larivière |
Not under active development |
Under Development |
|
|
|
|
| 219 |
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior |
Florence Pagé-Larivière |
Not under active development |
Under Development |
|
|
|
|
| 221 |
Mental stress to depression |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 222 |
Mental stress to agitation |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 223 |
Serotonin transporter activation to seizure |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 224 |
Serotonin transporter activation to depression |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 225 |
Serotonin transporter activation to agitation |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 226 |
SSRI (Selective serotonin reuptake inhibitor) to hypertension |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 227 |
NSAID induced PTGS1 inactivation to gastric ulcer |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 228 |
NSAID induced PTGS2 inactivation to gastric ulcer |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 229 |
Helicobacter pylori to gastric ulcer |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 230 |
presynaptic neuron 1 activation to epilepsy |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 231 |
presynaptic neuron 2 repression to epilepsy |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 232 |
NFE2/Nrf2 repression to steatosis |
Lyle Burgoon |
Open for adoption |
Under Development |
|
|
|
|
| 238 |
Excessive reactive oxygen species production leading to population decline via lipid peroxidation |
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 241 |
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis |
Marvin Martens |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 242 |
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity |
Stefan Scholz |
Open for adoption |
|
|
|
|
|
| 245 |
Reduction in photophosphorylation leading to growth inhibition in aquatic plants |
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
|
|
|
|
|
| 256 |
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity |
Angela Mally |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.43 |
| 257 |
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity |
Angela Mally |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.43 |
| 258 |
Renal protein alkylation leading to kidney toxicity |
Angela Mally |
Not under active development |
Included in OECD Work Plan |
|
|
Under Development |
1.43 |
| 261 |
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
| 262 |
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
| 263 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (1) |
You Song |
Open for comment. Do not cite |
Under Development |
|
|
|
|
| 264 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (2) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 265 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (3) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 266 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (4) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 267 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (5) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 268 |
Uncoupling of oxidative phosphorylation leading to growth inhibition (6) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 271 |
Inhibition of thyroid peroxidase leading to impaired fertility in fish |
June-Woo Park |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.59 |
| 272 |
Direct deposition of ionizing energy leading to lung cancer |
Vinita Chauhan |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.56 |
| 277 |
Impaired IL-1R1 signaling leading to increased susceptibility to infection |
Yutaka Kimura |
Open for citation & comment |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.48 |
| 282 |
Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions |
Satomi Onoue |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.49 |
| 283 |
L-type calcium channel blockade leading to hypotension |
Luigi Margiotta-Casaluci |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.45 |
| 286 |
Mitochondrial complex III antagonism leading to growth inhibition (1) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 287 |
Mitochondrial complex III antagonism leading to growth inhibition (2) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 289 |
Inhibition of 5α-reductase leading to impaired fecundity in female fish |
Young Jun Kim |
Open for citation & comment |
Included in OECD Work Plan |
|
|
Under Development |
1.81 |
| 290 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (1) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 291 |
Mitochondrial ATP synthase antagonism leading to growth inhibition (2) |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 292 |
Inhibition of tyrosinase leads to decreased population in fish |
Young Jun Kim |
Open for citation & comment |
Included in OECD Work Plan |
|
|
Under Development |
1.78 |
| 293 |
Increased DNA damage leading to increased risk of breast cancer |
Jessica Helm |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.80 |
| 294 |
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer |
Jessica Helm |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.80 |
| 295 |
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk |
Andrea Hindman |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.79 |
| 296 |
Oxidative DNA damage leading to chromosomal aberrations and mutations |
Carole Yauk |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.76 |
| 297 |
Inhibition of retinaldehyde dehydrogenase leads to population decline |
Young Jun Kim |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
|
|
Under Development |
1.77 |
| 298 |
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer |
Shihori Tanabe |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
|
|
Under Development |
1.58 |
| 299 |
Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation |
You Song |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 302 |
Lung surfactant function inhibition leading to immediate adverse lung effects |
Jorid Birkelund Sørli |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.87 |
| 303 |
Frustrated phagocytosis-induced lung cancer |
Carole Seidel |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.86 |
| 305 |
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.90 |
| 306 |
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.90 |
| 307 |
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring |
Terje Svingen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.90 |
| 313 |
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease |
Hiroyuki Komatsu |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.75 |
| 314 |
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) |
Yasuharu Otsubo |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.73 |
| 315 |
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response |
Yasuhiro Yoshida |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.74 |
| 316 |
Trypsin inhibition leading to pancreatic acinar cell tumors |
Shigeru Hisada |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.60 |
| 336 |
DNA methyltransferase inhibition leading to population decline (1) |
You Song |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
|
| 337 |
DNA methyltransferase inhibition leading to population decline (2) |
You Song |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
|
| 339 |
DNA methyltransferase inhibition leading to population decline (4) |
You Song |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
|
| 340 |
DNA methyltransferase inhibition leading to transgenerational effects (1) |
You Song |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
|
| 341 |
DNA methyltransferase inhibition leading to transgenerational effects (2) |
You Song |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
|
| 146 |
Estrogen Receptor Activation and Female Precocious Puberty |
Jeff Welch |
Under Development: Contributions and Comments Welcome |
Under Development |
ER |
|
|
1.29 |
| 148 |
EGFR Activation Leading to Decreased Lung Function |
Karsta Luettich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
EGFR |
|
Under Development |
1.51 |
| 149 |
Peptide Oxidation Leading to Hypertension |
Frazer Lowe |
Not under active development |
Included in OECD Work Plan |
|
|
Under Development |
1.50 |
| 151 |
AhR activation leading to placental insufficiency |
Sabrina Tait |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.42 |
| 152 |
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity |
Erik Janus |
Open for adoption |
Included in OECD Work Plan |
Transthyretin |
|
Under Development |
1.41 |
| 153 |
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats |
Tammy Stoker |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 154 |
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response |
Takumi Ohishi |
Open for comment. Do not cite |
Included in OECD Work Plan |
Calcineurin Activity, Inhibition |
|
EAGMST Under Review |
1.38 |
| 155 |
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
| 156 |
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
| 157 |
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
| 158 |
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
| 159 |
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation |
Dries Knapen |
Open for adoption |
Included in OECD Work Plan |
|
|
Under Development |
1.35 |
| 160 |
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality |
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 161 |
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality |
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 162 |
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 163 |
PPARgamma activation leading to sarcomas in rats, mice, and hamsters |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 164 |
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 165 |
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 166 |
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 167 |
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 168 |
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 169 |
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 170 |
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 171 |
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 173 |
Substance interaction with the lung resident cell membrane components leading to lung fibrosis |
Sabina Halappanavar |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.32 |
| 175 |
Thyroperoxidase inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 176 |
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 177 |
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 178 |
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 179 |
Varroa mite infestation increases virus levels leading to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 180 |
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 181 |
Weather event contributes to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 182 |
Weather event contributes abnormal foraging leading to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 183 |
Nosema infection increases energetic demands leading to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 184 |
Nosema infection causes abnormal role change that leads to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 185 |
Queen egg-laying decrease leads to colony loss/failure |
Carlie LaLone |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 186 |
unknown MIE leading to renal failure and mortality |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 187 |
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage |
Barnett Rattner |
Not under active development |
Included in OECD Work Plan |
|
|
Under Development |
1.31 |
| 188 |
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 189 |
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 190 |
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 191 |
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 192 |
Pendrin inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 193 |
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 194 |
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis |
Jonathan Haselman |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 195 |
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 196 |
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation |
Jeanelle Martinez |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 197 |
Sodium channel (Nav1.1) inhibition leading to population decline |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
|
|
|
1.29 |
| 199 |
ER mediated breast cancer AOP |
Molly M Morgan |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 200 |
Estrogen receptor activation leading to breast cancer |
Molly M Morgan |
Open for adoption |
Under Development |
|
|
|
|
| 201 |
Juvenile hormone receptor agonism leading to male offspring induction associated population decline |
Knut Erik Tollefsen |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 202 |
Inhibitor binding to topoisomerase II leading to infant leukaemia |
Andrea Terron |
Open for comment. Do not cite |
Included in OECD Work Plan |
|
|
EAGMST Under Review |
1.53 |
| 206 |
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis |
Jinhee Choi |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.54 |
| 233 |
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening |
Timothy Allen |
Not under active development |
Under Development |
|
|
|
|
| 234 |
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition |
Timothy Allen |
Not under active development |
Under Development |
|
|
|
|
| 235 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening |
Timothy Allen |
Not under active development |
Under Development |
|
|
|
|
| 236 |
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition |
Timothy Allen |
Not under active development |
Under Development |
|
|
|
|
| 237 |
Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression |
Sarah Søs Poulsen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
|
Under Development |
1.55 |
| 239 |
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling |
Annie Jarabek |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 240 |
DNA Adducts Leading to Liver Hemangiosarcoma |
Annie Jarabek |
Under development: Not open for comment. Do not cite |
Under Development |
|
|
|
|
| 16 |
Acetylcholinesterase inhibition leading to acute mortality |
Dan Villeneuve |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
AChE |
acute mortality |
Under Development |
1.3 |
| 96 |
Axonal sodium channel modulation leading to acute mortality |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
sodium channel |
acute mortality |
|
1.29 |
| 113 |
Glutamate-gated chloride channel activation leading to acute mortality |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
GluCl Channel |
acute mortality |
|
1.29 |
| 105 |
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
Alpha2u |
adenomas and carcinomas |
|
1.29 |
| 117 |
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Open for adoption |
Included in OECD Work Plan |
AR |
adenomas and carcinomas |
Under Development |
1.26 |
| 72 |
Epigenetic modification of PPARG leading to adipogenesis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
PPARg |
adipogenesis |
|
1.29 |
| 19 |
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) |
Mukesh Patel |
Open for adoption |
Under Development |
AR |
adverse effects in the male foetus |
|
|
| 52 |
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males |
Tom Hutchinson |
Under Development: Contributions and Comments Welcome |
Under Development |
ER |
altered sexual differentiation |
|
1.29 |
| 106 |
Chemical binding to tubulin in oocytes leading to aneuploid offspring |
Francesco Marchetti |
Open for citation & comment |
Included in OECD Work Plan |
tubulin? |
aneuploid offspring |
EAGMST Under Review |
1.11 |
| 109 |
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
cytotox is not MIE |
bronchioloalveolar adenomas and carcinomas |
|
1.29 |
| 139 |
Alkylation of DNA leading to cancer 1 |
Carole Yauk |
Open for adoption |
Under Development |
DNA alkylation |
cancer |
|
|
| 11 |
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol |
Jun Kanno |
Not under active development |
Included in OECD Work Plan |
|
case study |
Under Development |
2.5 |
| 27 |
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) |
Mathieu Vinken |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
ABCB11 |
cholestatic liver injury |
Under Development |
1.19 |
| 300 |
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
Thyroid Receptor Antagonism |
Cognitve function, Decreased |
Under Development |
1.84 |
| 77 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 78 |
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 79 |
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 80 |
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 81 |
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
metabolic stress is not MIE |
colony loss/failure |
|
1.29 |
| 82 |
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
unk |
colony loss/failure |
|
1.29 |
| 84 |
Suppression of immune system contributes to impaired development and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
unclear |
colony loss/failure |
|
1.29 |
| 85 |
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
unclear |
colony loss/failure |
|
1.29 |
| 86 |
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
glucose oxidase |
colony loss/failure |
|
1.29 |
| 87 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 88 |
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 89 |
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 90 |
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 |
Carlie LaLone |
Open for comment. Do not cite |
Under Development |
nAChR |
colony loss/failure |
|
1.29 |
| 94 |
Sodium channel inhibition leading to congenital malformations |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
sodium channel |
congenital malformations |
|
1.29 |
| 136 |
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors |
Justin Teeguarden |
Open for citation & comment |
Included in OECD Work Plan |
unclear |
contact nasal tumors |
EAGMST Under Review |
2.7 |
| 114 |
HPPD inhibition leading to corneal papillomas and carcinomas (in rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
HPPD |
corneal papillomas and carcinomas |
|
1.29 |
| 124 |
HMG-CoA reductase inhibition leading to decreased fertility |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
HMG-CoA reductase |
decreased fertility |
|
1.29 |
| 64 |
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility |
Susan Laws |
Under Development: Contributions and Comments Welcome |
Under Development |
GR |
decreased male fertitlity |
|
1.29 |
| 126 |
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation |
Tammy Stoker |
Under Development: Contributions and Comments Welcome |
Under Development |
alpha Norad Receptors |
delayed ovulation |
|
1.29 |
| 43 |
Disruption of VEGFR Signaling Leading to Developmental Defects |
Tom Knudsen |
Open for citation & comment |
Included in OECD Work Plan |
VEGF |
developmental outcomes |
EAGMST Under Review |
1.6 |
| 21 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2 |
Markus Hecker |
Open for citation & comment |
Included in OECD Work Plan |
AhR |
embryo toxicity |
TFHA/WNT Endorsed |
1.27 |
| 112 |
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
dopamine?? |
endometrial adenocarcinomas |
|
1.29 |
| 26 |
Calcium-mediated neuronal ROS production and energy imbalance |
Lyle Burgoon |
Open for adoption |
Under Development |
unclear |
energy imbalance |
|
|
| 10 |
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain |
Ping Gong |
Open for citation & comment |
Included in OECD Work Plan |
GABA |
epileptic seizures |
TFHA/WNT Endorsed |
1.15 |
| 110 |
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
NIS |
follicular cell adenomas and carcinomas |
|
1.29 |
| 119 |
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
TPO |
follicular cell adenomas and carcinomas |
|
1.29 |
| 115 |
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
cytotox not MIE |
forestomach tumors |
|
1.29 |
| 31 |
Oxidation of iron in hemoglobin leading to hematotoxicity |
Mitchell S. Wilbanks |
Open for adoption |
Included in OECD Work Plan |
heme oxidation ? |
hematotoxicity |
Under Development |
1.16 |
| 57 |
AhR activation leading to hepatic steatosis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
AhR |
hepatic steatosis |
|
1.29 |
| 58 |
NR1I3 (CAR) suppression leading to hepatic steatosis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
CAR |
hepatic steatosis |
|
1.29 |
| 59 |
HNF4alpha suppression leading to hepatic steatosis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
HNF4alpha |
hepatic steatosis |
|
1.29 |
| 60 |
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
PXR |
hepatic steatosis |
|
1.29 |
| 61 |
NFE2L2/FXR activation leading to hepatic steatosis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
multiple |
hepatic steatosis |
|
1.29 |
| 62 |
AKT2 activation leading to hepatic steatosis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
AKT2 |
hepatic steatosis |
|
1.29 |
| 107 |
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat |
Kristin Lichti-Kaiser |
Open for citation & comment |
Included in OECD Work Plan |
CAR |
hepatocellular adenomas and carcinomas |
EAGMST Under Review |
1.17 |
| 118 |
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
cytotox is not MIE |
hepatocellular adenomas and carcinomas |
|
1.29 |
| 46 |
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) |
Ted Simon |
Open for citation & comment |
Included in OECD Work Plan |
AFB1 |
hepatocellular carcinoma |
EAGMST Under Review |
1.8 |
| 108 |
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
pyruvate dehydrogenase |
hepatocellular carcinoma |
|
1.29 |
| 130 |
Phospholipase A inhibitors lead to hepatotoxicity |
Jung-Hwa Oh |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
phospolipase A |
hepatotoxicity |
Under Development |
1.39 |
| 15 |
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations |
Carole Yauk |
Open for citation & comment |
Included in OECD Work Plan |
DNA alkylation |
heritable mutations |
TFHA/WNT Endorsed |
1.11 |
| 7 |
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female |
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
impaired fertility |
EAGMST Under Review |
1.21 |
| 18 |
PPARα activation in utero leading to impaired fertility in males |
Elise Grignard |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
impaired fertility |
EAGMST Under Review |
1.21 |
| 51 |
PPARα activation leading to impaired fertility in adult male rodents |
Elise Grignard |
Not under active development |
Included in OECD Work Plan |
PPAR α |
impaired fertility |
Under Development |
1.21 |
| 104 |
Altered ion channel activity leading impaired heart function |
Kevin Dreher |
Under Development: Contributions and Comments Welcome |
Under Development |
multiple |
impaired heart function |
|
1.29 |
| 13 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
NMDAR |
impairment of learning and memory abilities |
TFHA/WNT Endorsed |
1.22 |
| 150 |
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF |
Amani Farhat |
Open for citation & comment |
Included in OECD Work Plan |
Activation, AhR |
Increase, Early Life Stage Mortality |
TFHA/WNT Endorsed |
1.7 |
| 14 |
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility |
Carlie LaLone |
Open for comment. Do not cite |
|
GR |
increased disease susceptibility |
|
1.29 |
| 93 |
sodium channel inhibition leading to increased predation |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
sodium channel |
increased predation |
|
1.29 |
| 97 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
5-HTT |
increased predation |
|
1.29 |
| 98 |
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation |
Ksenia Groh |
Under Development: Contributions and Comments Welcome |
|
5-HTT |
increased predation |
|
1.29 |
| 33 |
Kidney toxicity induced by activation of 5HT2C |
Kevin Crofton |
Open for adoption |
Under Development |
5-HTT2c |
kidney toxicity |
|
|
| 128 |
Kidney dysfunction by decreased thyroid hormone |
Jung-Hwa Oh |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
unclear - KE as MIE? |
kidnney dysfunction |
Under Development |
1.40 |
| 54 |
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
NIS |
learning and memory deficits in children |
TFHA/WNT Endorsed |
1.28 |
| 48 |
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. |
Anna Price |
Open for citation & comment |
Included in OECD Work Plan |
Glutamate Receptor |
learning and memory impairment. |
TFHA/WNT Endorsed |
1.23 |
| 111 |
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
AR |
leydig cell tumors |
|
1.29 |
| 120 |
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
5α-reductase |
leydig cell tumors |
|
1.29 |
| 37 |
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents |
Chris Corton |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
PPAR alpha |
liver cancer |
Under Development |
1.17 |
| 220 |
Cyp2E1 Activation Leading to Liver Cancer |
Francina Webster |
Open for citation & comment |
Included in OECD Work Plan |
Activation of Cyp2E1 |
liver cancer |
EAGMST Under Review |
1.24 |
| 38 |
Protein Alkylation leading to Liver Fibrosis |
Brigitte Landesmann |
Open for citation & comment |
Included in OECD Work Plan |
Protein alkylation |
liver fibrosis |
TFHA/WNT Endorsed |
1.14 |
| 34 |
LXR activation leading to hepatic steatosis |
Marina Goumenou |
Not under active development |
Under Development |
LXR |
liver steatosis |
|
|
| 32 |
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors |
Michelle Embry |
Not under active development |
Under Development |
nitric oxide |
liver tumors |
|
|
| 41 |
Sustained AhR Activation leading to Rodent Liver Tumours |
Rick Becker |
Open for citation & comment |
Included in OECD Work Plan |
AhR |
liver tumors |
EAGMST Under Review |
1.7 |
| 144 |
Endocytic lysosomal uptake leading to liver fibrosis |
Marina Kuburic |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
|
Liver, Inflammation |
EAGMST Under Review |
1.47 |
| 66 |
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis |
Gary Klinefelter |
Under Development: Contributions and Comments Welcome |
Under Development |
GR |
modulation of leydig cell function |
|
1.29 |
| 67 |
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis |
Gary Klinefelter |
Under Development: Contributions and Comments Welcome |
Under Development |
estradiol |
modulation of leydig cell function |
|
1.29 |
| 68 |
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome |
Gary Klinefelter |
Under Development: Contributions and Comments Welcome |
Under Development |
proteins - undefined |
modulation of leydig cell function |
|
1.29 |
| 69 |
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell |
Gary Klinefelter |
Under Development: Contributions and Comments Welcome |
Under Development |
multiple |
modulation of leydig cell function |
|
1.29 |
| 70 |
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell |
Gary Klinefelter |
Under Development: Contributions and Comments Welcome |
Under Development |
|
modulation of leydig cell function |
|
1.29 |
| 71 |
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation |
Gary Klinefelter |
Under Development: Contributions and Comments Welcome |
Under Development |
GR |
modulation of leydig cell function |
|
1.29 |
| 74 |
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis |
Gary Klinefelter |
Under Development: Contributions and Comments Welcome |
Under Development |
unk |
modulation of leydig cell function |
|
1.29 |
| 4 |
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality |
Knut Erik Tollefsen |
Open for citation & comment |
Under Development |
EcR |
mortality |
|
|
| 3 |
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits |
Andrea Terron |
Open for citation & comment |
Included in OECD Work Plan |
NADH-ubiquinone oxidoreductase (complex I), Binding of inhibitor |
Motor function, impaired |
TFHA/WNT Endorsed |
1.33 |
| 8 |
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Katie Paul Friedman |
Not under active development |
Included in OECD Work Plan |
mulitple |
neurodevelopmental outcomes |
Under Development |
1.9 |
| 42 |
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Kevin Crofton |
Open for citation & comment |
Included in OECD Work Plan |
TPO |
neurodevelopmental outcomes |
TFHA/WNT Endorsed |
1.10 |
| 134 |
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals |
Mary Gilbert |
Under Development: Contributions and Comments Welcome |
Under Development |
NIS |
neurodevelopmental outcomes |
|
1.29 |
| 12 |
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging |
Florianne Tschudi-Monnet |
Open for citation & comment |
Included in OECD Work Plan |
NMDAR |
neuroinflammation and lead to neurodegeneration |
TFHA/WNT Endorsed |
1.13 |
| 17 |
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory |
Marie-Gabrielle Zurich |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
multiple |
neuroinflammation leading to neurodegeneration |
EAGMST Under Review |
1.13 |
| 73 |
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity |
Tammy Stoker |
Under Development: Contributions and Comments Welcome |
Under Development |
DBH |
reduced fecundity |
|
1.29 |
| 53 |
ER agonism leading to reduced survival due to renal failure |
Tom Hutchinson |
Under Development: Contributions and Comments Welcome |
Under Development |
ER |
reduced survival |
|
1.29 |
| 91 |
Sodium channel inhibition leading to reduced survival |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
sodium channel |
reduced survival |
|
1.29 |
| 95 |
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
ERG |
reduced survival |
|
1.29 |
| 99 |
Histamine (H2) receptor antagonism leading to reduced survival |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
H2 |
reduced survival |
|
1.29 |
| 138 |
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality |
Kellie Fay |
Under Development: Contributions and Comments Welcome |
Under Development |
p-amino hippuric acid |
renal failure and mortality |
|
1.29 |
| 116 |
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
cytotox is not MIE |
renal tubular adenomas and carcinomas |
|
1.29 |
| 23 |
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
AR |
reproductive dysfunction |
TFHA/WNT Endorsed |
1.12 |
| 25 |
Aromatase inhibition leading to reproductive dysfunction |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
Aromatate Inhib |
reproductive dysfunction |
TFHA/WNT Endorsed |
1.12 |
| 29 |
Estrogen receptor agonism leading to reproductive dysfunction |
Tom Hutchinson |
Under Development: Contributions and Comments Welcome |
Under Development |
ER |
reproductive dysfunction |
|
1.29 |
| 30 |
Estrogen receptor antagonism leading to reproductive dysfunction |
Dan Villeneuve |
Open for citation & comment |
Included in OECD Work Plan |
ER |
reproductive dysfunction |
EAGMST Under Review |
1.12 |
| 63 |
Cyclooxygenase inhibition leading to reproductive dysfunction |
Dalma Martinovic-Weigelt |
Under Development: Contributions and Comments Welcome |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
| 100 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior |
Dalma Martinovic-Weigelt |
Under Development: Contributions and Comments Welcome |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
| 101 |
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release |
Dalma Martinovic-Weigelt |
Under Development: Contributions and Comments Welcome |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
| 102 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition |
Dalma Martinovic-Weigelt |
Under Development: Contributions and Comments Welcome |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
| 103 |
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint |
Dalma Martinovic-Weigelt |
Under Development: Contributions and Comments Welcome |
Under Development |
cyclooxygenase |
reproductive dysfunction |
|
1.29 |
| 122 |
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation |
Dalma Martinovic-Weigelt |
Under Development: Contributions and Comments Welcome |
Under Development |
Prolyl hydroxylase |
reproductive dysfunction |
|
1.29 |
| 123 |
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription |
Dalma Martinovic-Weigelt |
Under Development: Contributions and Comments Welcome |
Under Development |
Unknown |
reproductive dysfunction |
|
1.29 |
| 28 |
Cyclooxygenase inhibition leading reproductive failure |
Dan Villeneuve |
Under Development: Contributions and Comments Welcome |
Under Development |
cyclooxygenase |
reproductive failure |
|
1.29 |
| 35 |
Narcosis leading to respiratory failure |
Dries Knapen |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
undefined |
sensitisation of the respiratory tract |
Under Development |
1.2 |
| 39 |
Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract |
Kristie Sullivan |
Under Development: Contributions and Comments Welcome |
Included in OECD Work Plan |
unclear what proteins |
sensitisation of the respiratory tract |
Under Development |
1.20 |
| 40 |
Covalent Protein binding leading to Skin Sensitisation |
Sharon Munn |
Open for citation & comment |
Included in OECD Work Plan |
Covalent Binding, Protein |
sensitisation, skin |
TFHA/WNT Endorsed |
1.1 |
| 6 |
Antagonist binding to PPARα leading to body-weight loss |
Kurt A. Gust |
Open for citation & comment |
Included in OECD Work Plan |
PPAR |
starvation-like body-weight loss |
TFHA/WNT Endorsed |
2.3 |
| 36 |
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis |
Michelle Angrish |
Under Development: Contributions and Comments Welcome |
Under Development |
b-oxidation fatty acid |
steatosis |
|
1.29 |
| 212 |
Histone deacetylase inhibition leading to testicular atrophy |
Shihori Tanabe |
Under development: Not open for comment. Do not cite |
Included in OECD Work Plan |
Histone deacetylase, inhibition |
testicular toxicity |
EAGMST Under Review |
1.52 |
| 131 |
Aryl hydrocarbon receptor activation leading to uroporphyria |
Amani Farhat |
Open for citation & comment |
Included in OECD Work Plan |
AhR |
uroporphyria |
TFHA/WNT Endorsed |
1.7 |
| 121 |
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) |
Charles Wood |
Under Development: Contributions and Comments Welcome |
Under Development |
unclear |
urothelial papillomas and carcinomas |
|
1.29 |