AOPs

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Showing 1 to 25 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
646 Binding and activation of AhR/PPARγ lead to lipid metabolism disorders Shiheng Gui BY-SA 1995: Abnormal lipid metabolism
645 Binding and activation of AhR lead to cardiovascular aging Shiheng Gui BY-SA 2430: Aryl hydrocarbon receptor（AhR）activation 2438: Increase, Cardiovascular aging
644 Bulky DNA adducts leading to chromosomal aberrations and mutations Beckner Andersano BY-SA 1879: Bulky DNA adducts, increase
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2418: Increased, phenotypic female-biased sex ratio
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle John Frisch BY-SA 1065: Activation, estrogen receptor alpha 406: decreased, Fertility
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2415: Precocious puberty
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2413: Increased, uterine weight
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) You Song BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) You Song BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) You Song BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) You Song BY-SA None None
631 Decreased thyroid hormone receptor beta transcriptional activity leading to MASLD progression via endoplasmic reticulum stress You Song BY-SA None None
630 Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2409: Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity None Under Development
629 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
628 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
627 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
625 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
624 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
623 Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2306: Persistent vaginal cornification
622 Calcineurin inhibitor induced nephrotoxicity leading to kidney failure Kate Liang BY-SA None 759: Increased, Kidney Failure
621 NOX2 Driven Oxidative Stress-Induced α-Synuclein Radical Formation and Tau Nitration Leading to Neurodegeneration Tejasvi kumar Open for adoption None None