AOPs

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Showing 226 to 250 of 593 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
396 Deposition of ionizing energy leads to population decline via impaired meiosis Erica Maremonti BY-SA 1550: Deposition of Ionizing Energy
389 Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1865: Increase, Oxygen-evolving complex damage
388 Deposition of ionising energy leading to population decline via programmed cell death Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
387 Deposition of ionising energy leading to population decline via mitochondrial dysfunction Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
386 Deposition of ionizing energy leading to population decline via inhibition of photosynthesis Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
384 Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease Young Jun Kim BY-SA 1853: Hyperactivation of ACE/Ang-II/AT1R axis 1603: Chronic kidney disease
325 Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
326 Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
327 Excessive reactive oxygen species production leading to mortality (1) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
331 Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
332 Increase in reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
322 Alkylation of DNA leading to decreased sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Decrease, Sperm count
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARα
324 Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
275 Histone deacetylase inhibition leads to neural tube defects Marvin Martens BY-SA 1502: Histone deacetylase inhibition 1561: Neural tube defects
310 Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR Jon Doering BY-SA 18: Activation, AhR
309 Luteinizing hormone receptor antagonism leading to reproductive dysfunction Young Jun Kim BY-SA 1691: Antagonism,LH receptor 679: Decline, Population trajectory
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee BY-SA 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
301 Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis Young Jun Kim BY-SA 1657: Inhibition of cystathionine beta-synthase 1667: Impaired,anterior-posterior axis development
288 Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) Bérénice COLLET BY-SA 1609: Inhibition, Cytochrome P450 enzyme (CYP17A1) activity 1616: Malformation, cryptorchidism - maldescended testis
285 Inhibition of N-linked glycosylation leads to liver injury Marvin Martens BY-SA 1604: Inhibition of N-linked glycosylation 1549: Liver Injury
284 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease Frederic Y. Bois BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 1603: Chronic kidney disease