AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 251 to 275 of 591 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA 461: Suppression, HNF4alpha None
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Knut Erik Tollefsen BY-SA 103: Increase, Ecdysone receptor hyperactivation
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption 51: Inhibition, Ca++ ATPase 1392: Increase, Oxidative Stress
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve BY-SA 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
29 Estrogen receptor agonism leading to reproductive dysfunction Undefined BY-SA 111: Agonism, Estrogen receptor
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Undefined BY-SA None None
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption 9: Activation, 5HT2c 759: Increased, Kidney Failure
34 LXR activation leading to hepatic steatosis Undefined BY-SA 345: N/A, Liver Steatosis
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Undefined BY-SA 111: Agonism, Estrogen receptor 417: skewed, sex ratio
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA 111: Agonism, Estrogen receptor None
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA 18: Activation, AhR 459: Increase, Liver steatosis
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
74 Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis Undefined BY-SA 662: Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis 543: Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish BY-SA 245: Activation, PXR/SXR 459: Increase, Liver steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
62 AKT2 activation leading to hepatic steatosis Michelle Angrish BY-SA 486: systemic inflammation leading to hepatic steatosis 459: Increase, Liver steatosis
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Undefined BY-SA 494: Glucocorticoid Receptor Agonist, Activation 406: decreased, Fertility
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Undefined BY-SA 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Undefined BY-SA 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Undefined BY-SA 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility