AOPs

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Showing 276 to 300 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Undefined BY-SA 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility
72 Epigenetic modification of PPARG leading to adipogenesis Michelle Angrish BY-SA 1447: obesity
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Undefined BY-SA 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA 798: Inhibition, Prolyl hydroxylases
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood BY-SA None 741: Increase, Adenomas/carcinomas (follicular cell)
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen BY-SA 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen BY-SA 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Undefined BY-SA 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol 972: Decreased fertility, Reduced number of oocytes ovulated
146 Estrogen Receptor Activation and Female Precocious Puberty Undefined Open for adoption None None
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption 97: Alkylation, DNA 885: Increase, Cancer
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 877: Inhibition, organic anion transporter 1 (OAT1)
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert BY-SA 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive function, decreased
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Undefined BY-SA 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood BY-SA 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar)
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1617: Inhibition, 5α-reductase 745: Increase, Leydig cell tumors
119 Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) Charles Wood BY-SA 279: Thyroperoxidase, Inhibition 741: Increase, Adenomas/carcinomas (follicular cell)
118 Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 786: Increase, Cytotoxicity (hepatocytes) 719: Increase, hepatocellular adenomas and carcinomas
116 Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) Charles Wood BY-SA 783: Increase, Cytotoxicity (tubular epithelial cells) 713: Increase, Adenomas/carcinomas (renal tubular)
115 Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) Charles Wood BY-SA 780: Increase, Cytotoxicity (epithelial cells) 779: Increase, Papillomas/carcinomas (squamous cells)
114 HPPD inhibition leading to corneal papillomas and carcinomas (in rat) Charles Wood BY-SA 766: Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme 779: Increase, Papillomas/carcinomas (squamous cells)
113 Glutamate-gated chloride channel activation leading to acute mortality Helen Poynton BY-SA 760: Activation, Glutamate-gated chloride channel
112 Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) Charles Wood BY-SA 746: Increase, Dopaminergic activity 773: Increase, Endometrial adenocarcinomas