AOPs

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Showing 301 to 325 of 568 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
549 Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish Hongling Liu BY-SA 36: Inhibition, Aromatase
496 Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） Hongling Liu BY-SA 25: Agonism, Androgen receptor 442: Decreased, Population trajectory
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas Under Review 1.17
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA None None
495 Androgen receptor activation leading to prostate cancer Jianxiang Li BY-SA 25: Agonism, Androgen receptor 2135: Prostate cancer
531 VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction Hui Li BY-SA None None
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li BY-SA None None
408 Imbalance in redox homeostasis leading to structural damage to tissues Fei Li BY-SA None None
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA 1817: Apoptotic cell death
393 AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation Fei Li BY-SA 1158: Increased, Hepatic thyroid hormone uptake/transport None
401 G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects Fei Li BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 1489: Increase, Steatohepatitis
304 TBX1 inhibition leading to congenital cardiac conotruncal anomalies Jinsoo Lee BY-SA 1680: Inhibition, TBX1 1685: Anomalies, Congenital cardiac conotruncal
38 Protein Alkylation leading to Liver Fibrosis Brigitte Landesmann BY-SA 244: Alkylation, Protein 344: Increase, Liver fibrosis WPHA/WNT Endorsed 1.14
14 Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility Carlie LaLone BY-SA 122: Increase, Glucocorticoid receptor activation 323: Increased, Disease susceptibility
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
181 Weather event contributes to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony