AOPs

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Showing 301 to 325 of 594 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
343 Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade You Song BY-SA 2374: Increase, Ecdysone receptor antagonism
342 Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade You Song BY-SA 103: Increase, Ecdysone receptor hyperactivation
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
340 DNA methyltransferase inhibition leading to transgenerational effects (1) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
339 DNA methyltransferase inhibition leading to population decline (4) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
338 DNA methyltransferase inhibition leading to population decline (3) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
337 DNA methyltransferase inhibition leading to population decline (2) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
336 DNA methyltransferase inhibition leading to population decline (1) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza BY-SA 177: Increase, Mitochondrial dysfunction 1763: Urothelial Tumor
334 Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration Alexander Cole BY-SA 122: Increase, Glucocorticoid receptor activation 360: Decrease, Population growth rate
333 Increase in reactive oxygen species leading to growth inhibition via protein oxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
332 Increase in reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
331 Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
327 Excessive reactive oxygen species production leading to mortality (1) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
326 Increase in reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
325 Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
324 Increase in reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth Under Development
323 PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone Jennifer Olker BY-SA 227: Activation, PPARĪ±
322 Alkylation of DNA leading to decreased sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Decrease, Sperm count
321 Reduced environmental pH leading to thinner shells in Mytilus edulis James Ducker BY-SA None None
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA 1739: Binding to ACE2 351: Increased Mortality Under Development 1.96
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 1276: Lung fibrosis Under Development 1.96