AOPs

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Showing 301 to 325 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA 111: Agonism, Estrogen receptor None
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA 18: Activation, AhR 459: Increase, Liver steatosis
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Undefined BY-SA 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA 461: Suppression, HNF4alpha None
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish BY-SA 245: Activation, PXR/SXR 459: Increase, Liver steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
62 AKT2 activation leading to hepatic steatosis Michelle Angrish BY-SA 486: systemic inflammation leading to hepatic steatosis 459: Increase, Liver steatosis
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Undefined BY-SA 494: Glucocorticoid Receptor Agonist, Activation 406: decreased, Fertility
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Undefined BY-SA 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Undefined BY-SA 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Undefined BY-SA 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Undefined BY-SA 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility
194 Hepatic nuclear receptor activation leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1157: Activation, Hepatic nuclear receptor(s) 1101: Altered, Amphibian metamorphosis
185 Queen egg-laying decrease leads to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
186 unknown MIE leading to renal failure and mortality Kellie Fay BY-SA 1114: Unknown, MIE 351: Increased Mortality
188 Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1152: Inhibition, Iodotyrosine deiodinase (IYD) 1101: Altered, Amphibian metamorphosis
189 Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1009: Inhibition, Deiodinase 1 1101: Altered, Amphibian metamorphosis
190 Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1002: Inhibition, Deiodinase 2 1101: Altered, Amphibian metamorphosis
191 Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1153: Inhibition, Deiodinase 3 1101: Altered, Amphibian metamorphosis
192 Pendrin inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1155: Inhibition, Pendrin 1101: Altered, Amphibian metamorphosis
193 Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 1156: Inhibition, Dual oxidase 1101: Altered, Amphibian metamorphosis
184 Nosema infection causes abnormal role change that leads to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony