AOPs

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Showing 326 to 350 of 591 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
168 GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. Charles Wood BY-SA None 1079: Increased, Adenomas/carcinomas (mammary)
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood BY-SA None 1082: Increased, adenomas (pituitary)
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood BY-SA None 1079: Increased, Adenomas/carcinomas (mammary)
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood BY-SA None 1090: Increased, mesotheliomas
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation None
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 424: Inhibition, Na+/I- symporter (NIS) 1101: Altered, Amphibian metamorphosis
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 1103: Inhibition, Cyclooxygenase 1 activity
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
181 Weather event contributes to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption 1417: NFE2/Nrf2 repression 459: Increase, Liver steatosis
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Undefined BY-SA None None
240 DNA Adducts Leading to Liver Hemangiosarcoma Undefined BY-SA None None
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation