AOPs

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Showing 376 to 400 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
609 Activation, estrogen receptor alpha leads to prolonged estrus cycle via decreased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 1075: prolonged, estrus cycle
610 Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function Nathalie Dierichs All rights reserved
611 Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes Donggon Yoo BY-SA 2379: Disruption of the regulatory function of dopamine signaling components. 2382: Increase, nerve spasm
612 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
613 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
614 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
615 Suppression of Keap1 cysteine oxidation leading to liver inflammation Young Jun Kim All rights reserved 2385: Suppression of Keap1 cysteine oxidation 902: Inflammation, Liver
616 organic UV filter and its Photoproducts reproductive toxicity pathways Nataraj Bojan All rights reserved 2391: Reduced fertility / fecundity
617 The adverse outcome pathway of vascular calcification Ruiyang Ding All rights reserved None None
618 PPARgamma activation leads to a diminished vaccine response Léo SPORTES-MILOT BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation 2397: Diminished vaccine response
619 Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues Travis Karschnik BY-SA 26: Antagonism, Androgen receptor 2401: Male preputial separation, failed/delayed
620 The Adverse Outcome Pathway to Deposition of Energy Leading to Female Decreased Fertility Jessica D'Urbano All rights reserved None None
621 NOX2 Driven Oxidative Stress-Induced α-Synuclein Radical Formation and Tau Nitration Leading to Neurodegeneration Tejasvi kumar Open for adoption None None
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA None 1786: Nipple retention (NR), increased
576 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1786: Nipple retention (NR), increased
577 AhR activation leading to endometriosis Léna CAUDAL BY-SA 18: Activation, AhR None
578 AhR activation leading to cancer progression via immunosuppression Léo SPORTES-MILOT BY-SA 18: Activation, AhR 1971: Increased, tumor growth
579 Transthyretin disruption in developing fish leading to projected decline in fish population Adriana Webb BY-SA None None
580 Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index Théo Jamay All rights reserved 2331: Activation, Mineralocorticoid Receptor 2335: Increase, body mass index
581 Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease Marie-Gabrielle Zurich All rights reserved 122: Increase, Glucocorticoid receptor activation 402: Cognitive function, decreased
582 Inhibition of EphA2 phosphorylation leads to liver damage via the ERK/ MDM2/p53 axis Peihua Luo All rights reserved None None
583 Vascular endothelial HER2 inhibition disrupts cardiomyocyte calcium homeostasis via EGFR/STAT3/PTX3 axis leading to cardiac contractile dysfunction Peihua Luo All rights reserved None None
584 SQLE accumulation leads to hepatotoxicity via cholesterol/sphingolipid metabolic disturbance and lysosomal damage Peihua Luo All rights reserved None None
585 AKT Inhibition blocks the autophagy flow through the PRKAA/AMPK pathway and leads to cardiotoxicity Peihua Luo All rights reserved None None
586 The increasing accumulation of HMGB1 in the nucleus causes cardiomyocyte death via HMGB1/HSPB1/CCN2 pathway Peihua Luo All rights reserved None None