AOPs

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Showing 401 to 425 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
562 HCN Channel Inhibition leading to Arrhythmias Young Jun Kim BY-SA 2295: HCN Channel Inhibition 1106: Occurrence, cardiac arrhythmia
563 Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis Sapana Kushwaha BY-SA 18: Activation, AhR 2305: Premature ovarian Insufficiency
564 DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity. lihua Yang BY-SA 1541: Mitochondrial Complex I inhibition
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Martina Panzarea BY-SA 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None
566 Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation Martina Panzarea BY-SA None 2306: Persistent vaginal cornification
567 Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition Li Xie BY-SA 2307: Binding of plastoquinone B (QB) within D1 protein of Photosystem II
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding John Frisch BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Huimin Ma BY-SA 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA None 2082: Hypospadias, increased
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Young Jun Kim BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
556 Decreased Na/K ATPase activity leading to heart failure Young Jun Kim BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Young Jun Kim BY-SA 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
558 Phosphodiesterase inhibition leading to heart failure Young Jun Kim BY-SA 2288: Phosphodiesterase inhibition 1535: Heart failure
559 Inhibition of acetylcholinesterase (AChE) leading to arrhythmias Young Jun Kim BY-SA 12: Acetylcholinesterase (AchE) Inhibition 1106: Occurrence, cardiac arrhythmia
560 Inhibition of Funny current (If) leading to Arrhythmias Young Jun Kim Open for adoption 2290: Inhibition of Funny current (If) 1106: Occurrence, cardiac arrhythmia
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Martina Panzarea BY-SA 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
605 Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim BY-SA 279: Thyroperoxidase, Inhibition
604 Binding of Alpha 1-Adrenergics to Agonists Leading to Depression LUANA GOMES All rights reserved 2370: Agonism binding, α1-Adrenoreceptor 1346: Increased, depression
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
602 Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
601 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
600 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
599 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
598 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth