AOPs

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Showing 426 to 450 of 594 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
553 Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure Young Jun Kim BY-SA 584: Inhibition, sodium channel 1535: Heart failure
554 β-adrenergic receptor agonists leading to arrhythmias. Young Jun Kim BY-SA 1038: Activation, beta-2 adrenergic receptor 1106: Occurrence, cardiac arrhythmia
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Young Jun Kim BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
556 Decreased Na/K ATPase activity leading to heart failure Young Jun Kim BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Young Jun Kim BY-SA 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
558 Phosphodiesterase inhibition leading to heart failure Young Jun Kim BY-SA 2288: Phosphodiesterase inhibition 1535: Heart failure
539 Decreased Sodium/Potassium ATPase activity leads to Heart failure John Frisch BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Kevin Brix BY-SA 1115: Increase, Reactive oxygen species 360: Decrease, Population growth rate
541 Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching Ruiyang Ding BY-SA None None
543 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
544 Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
545 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
546 Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
423 Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway Fei Li BY-SA 1817: Apoptotic cell death
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout BY-SA None None
471 Neuron defect induced early behavioral change Woo-Keun Kim BY-SA 2195: Increase, CNS Neural cell death
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA 1686: Deposition of Energy
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang BY-SA
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing BY-SA 2007: Non-coding RNA expression profile alteration 2008: Chronic obstructive pulmonary disease
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Ruiyang Ding BY-SA None None
454 PM2.5-related AOP frameworks on liver diseases Zhou Du BY-SA None None
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Increase, Insulin resistance
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased