AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 426 to 450 of 589 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
597 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell growth You Song BY-SA None None
587 Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1542: Inhibition, Mitochondrial complex III 896: Parkinsonian motor deficits
595 Emerging OPFRS reproductive outcome pathway Shahena Perveen All rights reserved
594 Micro plastic effect on reproduction Shahena Perveen All rights reserved 1238: Activation of oxidative stress pathway 1277: Reproductive failure
593 Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons Stefan Schildknecht BY-SA 2362: Redox cycling of a chemical by mitochondria 896: Parkinsonian motor deficits
592 DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis lihua Yang BY-SA
591 DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration lihua Yang BY-SA 1194: Increase, DNA damage 2019: Non-alcoholic fatty liver disease
590 Increase of intracellular copper leading to cuproptosis via interference with energy metabolism Sophie Scholz BY-SA 2339: Intracellular copper, increased 2343: Cuproptosis, increased
589 Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1543: Mitochondrial Complex IV inhibition 896: Parkinsonian motor deficits
588 Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 2118: Succinate dehydrogenase, inhibited 896: Parkinsonian motor deficits
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
572 BMP4 Suppression Disrupting Cytoskeletal Remodeling Leading to Neural Tube Closure Defects Job Berkhout BY-SA None None
573 Inhibition, cytochrome oxidase leads to Increased, pulmonary edema John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2316: Increased, pulmonary edema
574 Inhibition, cytochrome oxidase leads to Loss of olfactory function John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2317: Loss of olfactory function
494 AhR activation leading to liver fibrosis Xavier COUMOUL BY-SA 18: Activation, AhR 344: Increase, Liver fibrosis
495 Androgen receptor activation leading to prostate cancer Jianxiang Li BY-SA 25: Agonism, Androgen receptor 2135: Prostate cancer
496 Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） Hongling Liu BY-SA 25: Agonism, Androgen receptor 442: Decreased, Population trajectory
497 ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation
498 Increased LCN2/iron complex leading to neurological disorders Young Jun Kim Open for adoption 2148: Increased LCN2/iron complex binds to SLC22A17 receptor in neuron 2150: Neurological disorder
499 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
500 Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis Travis Karschnik BY-SA 2146: Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2 341: Impairment, Learning and memory
501 Excessive iron accumulation leading to neurological disorders Young Jun Kim Open for adoption 2149: Increased intracelluar Iron accumulation 2150: Neurological disorder
504 SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level Martina Panzarea BY-SA 2155: Inhibition of Sulfotransferase E1 (SULT1E1) 1065: Activation, estrogen receptor alpha
539 Decreased Sodium/Potassium ATPase activity leads to Heart failure John Frisch BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
540 Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production Kevin Brix BY-SA 1115: Increase, Reactive oxygen species 360: Decrease, Population growth rate