AOPs

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Showing 451 to 475 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
358 Chitinase inhibition leading to mortality Simon Schmid BY-SA 1806: Inhibition, Chitinase 350: Increase, Mortality Under Development 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid BY-SA 1807: Inhibition, Chitobiase 350: Increase, Mortality Under Development 1.94
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid BY-SA 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality WPHA/WNT Endorsed 1.94
361 Sulfonylureareceptor binding leading to mortality Simon Schmid BY-SA 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality Under Development 1.94
363 Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure Lucia Vergauwen BY-SA 279: Thyroperoxidase, Inhibition Under Review 1.35
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim BY-SA 1637: Retinaldehyde dehydrogenase inhibition 360: Decrease, Population growth rate Under Development 1.77
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased Under Development 1.84
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA 1668: Frustrated phagocytosis 1670: Lung cancer Under Development 1.86
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1688: anogenital distance (AGD), decreased Under Review 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1688: anogenital distance (AGD), decreased Under Review 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA None 1688: anogenital distance (AGD), decreased Under Review 1.90
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu BY-SA 1706: Stimulation, TLR7/8 1709: Psoriatic skin disease Under Development 1.75
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim BY-SA 1627: Inhibition of tyrosinase 360: Decrease, Population growth rate Under Development 1.78
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA None None Under Development 1.79
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga BY-SA 1700: Impaired IL-1R1 signaling in T cell 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.48
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA 1115: Increase, Reactive oxygen species 1599: Inflamatory events in light-exposed tissues Under Review 1.49
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim BY-SA 1617: Inhibition, 5α-reductase 360: Decrease, Population growth rate Under Development 1.81