AOPs

OECD View API
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Showing 451 to 475 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
541 Excessive ROS generation leading to increased incidence of vascular calcification by VSMC phenotype switching Ruiyang Ding BY-SA None None
543 Inhibition of neuropathy target esterase leading to delayed neuropathy via lysolecithin cell membrane integration Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
544 Inhibition of neuropathy target esterase leading to delayed neuropathy via increased inflammation Brooke Bowe BY-SA 2262: Neuropathy target esterase, inhibited 2267: Delayed neuropathy, increased
545 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased cholesterol synthesis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
546 Succinate dehydrogenase inactivation leads to cancer through hypoxic-like mechanisms Sylvie Bortoli BY-SA 2118: Succinate dehydrogenase, inhibited 885: Increase, Cancer
547 Androgen receptor agonism leading to long anogenital distance in female offspring Johanna Zilliacus All rights reserved 25: Agonism, Androgen receptor 2365: Anogenital distance (AGD), increased
510 Demethylation of PPAR promotor leading to vascular disrupting effects Yanhong Wei BY-SA 228: peroxisome proliferator activated receptor promoter demethylation 2161: Increase, Vascular disrupting effects
511 The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects Yanhong Wei BY-SA 1115: Increase, Reactive oxygen species 2161: Increase, Vascular disrupting effects
512 Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level Ana-Andreea Cioca BY-SA None None
513 Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
514 PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV Hui Li BY-SA None None
515 An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects Liang Chen BY-SA None None
516 Na+ /K+ -ATPase inhibition leading to hypertension Michelle Angrish BY-SA 1562: Decreased Na/K ATPase activity 952: Hypertension
517 Pregnane X Receptor (PXR) activation leads to liver steatosis John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 459: Increase, Liver steatosis
518 Liver X Receptor (LXR) activation leads to liver steatosis John Frisch BY-SA 167: Activation, LXR 459: Increase, Liver steatosis
528 Decreased Insulin-like peptide 3 (INSL3) leads to Malformation, cryptorchidism - maldescended testis John Frisch BY-SA None 1616: Malformation, cryptorchidism - maldescended testis
529 Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis Erik Mylroie BY-SA 2226: Stressor binding PPAR isoforms 459: Increase, Liver steatosis
530 Endocytotic lysosomal uptake leads to intestinal barrier disruption Laure-Alix Clerbaux BY-SA 1539: Endocytotic lysosomal uptake 1931: Intestinal barrier, disruption
531 VEGFR inhibition leading to Keratinocyte differentiation-associate Hand-foot skin reaction Hui Li BY-SA None None
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 2231: Locomotor function. Impaired
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2232: Antagonism, Retinoic acid receptors 341: Impairment, Learning and memory
534 Succinate dehydrogenase (SDH) inhibition leads to oxidative stress Xavier COUMOUL BY-SA 2118: Succinate dehydrogenase, inhibited 1392: Increase, Oxidative Stress
535 Binding and activation of GPER leading to learning and memory impairments Zedong Ouyang BY-SA 2029: protein-coupled estrogen receptor 1 (GPER) activation 341: Impairment, Learning and memory
536 Estrogen receptor agonism leading to reduced survival and population growth due to renal failure Camille Baettig BY-SA 111: Agonism, Estrogen receptor None
537 Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver Jason M. O'Brien BY-SA 111: Agonism, Estrogen receptor 78: Reduction, Cumulative fecundity and spawning