AOPs

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Showing 26 to 50 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
560 Inhibition of Funny current (If) leading to Arrhythmias Young Jun Kim Open for adoption 2290: Inhibition of Funny current (If) 1106: Occurrence, cardiac arrhythmia
242 Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity Stefan Scholz Open for adoption 1462: Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
551 Increased Muscarinic M2 Receptor leading to Arrhythmia Young Jun Kim Open for adoption 1602: Increased Muscarinic Acetylcholine Receptors 1106: Occurrence, cardiac arrhythmia
519 Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality Young Jun Kim Open for adoption 2282: Cardiac ion channels blockade 1929: Increased incidence of cardiovascular morbidity and mortality in the general population
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 341: Impairment, Learning and memory
522 Estrogen antagonism leading to increased risk of autism-like behavior Kanglong Cui Open for adoption 112: Antagonism, Estrogen receptor 2209: autism-like behavior
523 Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 1978: Increase risk, microcephaly
525 Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory Ellen Fritsche Open for adoption 341: Impairment, Learning and memory
498 Increased LCN2/iron complex leading to neurological disorders Young Jun Kim Open for adoption 2148: Increased LCN2/iron complex binds to SLC22A17 receptor in neuron 2150: Neurological disorder
501 Excessive iron accumulation leading to neurological disorders Young Jun Kim Open for adoption 2149: Increased intracelluar Iron accumulation 2150: Neurological disorder
532 Retinoic acid receptor agonism during cerebellar development leading to impaired locomotor function Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 2231: Locomotor function. Impaired
533 Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2232: Antagonism, Retinoic acid receptors 341: Impairment, Learning and memory
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption 239: Activation, Pregnane-X receptor, NR1I2 319: Loss, Cochlear function Under Development 1.9
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
457 Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine Simon Thomas Open for adoption 2118: Succinate dehydrogenase, inhibited 2119: Increase, Insulin resistance
458 AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased
450 Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition
451 Interaction with lung resident cell membrane components leads to lung cancer Penny Nymark BY-SA 1495: Substance interaction with the lung resident cell membrane components 1670: Lung cancer
452 Adverse outcome pathway of PM-induced respiratory toxicity li qing BY-SA 2007: Non-coding RNA expression profile alteration 2008: Chronic obstructive pulmonary disease
453 Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population Ruiyang Ding BY-SA None None
454 PM2.5-related AOP frameworks on liver diseases Zhou Du BY-SA None None
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
481 AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases. Hailin Xu BY-SA 1115: Increase, Reactive oxygen species
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death