AOPs

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Showing 26 to 50 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim BY-SA 1796: 11β-hydroxylase inhibition 360: Decrease, Population growth rate Under Development 1.93
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased WPHA/WNT Endorsed 1.91
305 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1688: anogenital distance (AGD), decreased Under Review 1.90
306 Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1688: anogenital distance (AGD), decreased Under Review 1.90
307 Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring Terje Svingen BY-SA None 1688: anogenital distance (AGD), decreased Under Review 1.90
8 Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Katie Paul Friedman Open for adoption 239: Activation, Pregnane-X receptor, NR1I2 319: Loss, Cochlear function Under Development 1.9
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
302 Lung surfactant function inhibition leading to decreased lung function Jorid Birkelund Sørli BY-SA 1672: Inhibition of lung surfactant function 1250: Decrease, Lung function Under Development 1.87
303 Frustrated phagocytosis-induced lung cancer Carole Seidel BY-SA 1668: Frustrated phagocytosis 1670: Lung cancer Under Development 1.86
300 Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Kevin Crofton BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased Under Development 1.84
289 Inhibition of 5α-reductase leading to impaired fecundity in female fish Young Jun Kim BY-SA 1617: Inhibition, 5α-reductase 360: Decrease, Population growth rate Under Development 1.81
293 Increased DNA damage leading to increased risk of breast cancer Jessica Helm BY-SA 1194: Increase, DNA damage Under Development 1.80
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Under Review 1.8
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA None None Under Development 1.79
292 Inhibition of tyrosinase leads to decreased population in fish Young Jun Kim BY-SA 1627: Inhibition of tyrosinase 360: Decrease, Population growth rate Under Development 1.78