AOPs

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Showing 476 to 500 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 1276: Lung fibrosis Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA 1739: Binding to ACE2 351: Increased Mortality Under Development 1.96
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1786: Nipple retention (NR), increased Under Development 1.108
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA 26: Antagonism, Androgen receptor Under Development 1.109
555 Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure Young Jun Kim BY-SA 593: Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel 1535: Heart failure
556 Decreased Na/K ATPase activity leading to heart failure Young Jun Kim BY-SA 1562: Decreased Na/K ATPase activity 1535: Heart failure
557 β2-Receptor agonist leading to Cardiomyopathy Young Jun Kim BY-SA 1039: Increased activity, beta-2 adrenergic receptor 2157: Abnormal Cardiac Structure and Function
558 Phosphodiesterase inhibition leading to heart failure Young Jun Kim BY-SA 2288: Phosphodiesterase inhibition 1535: Heart failure
559 Inhibition of acetylcholinesterase (AChE) leading to arrhythmias Young Jun Kim BY-SA 12: Acetylcholinesterase (AchE) Inhibition 1106: Occurrence, cardiac arrhythmia
561 Aromatase induction leading to estrogen receptor alpha activation via increased estradiol Martina Panzarea BY-SA 2293: Aromatase, induction 1065: Activation, estrogen receptor alpha
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
605 Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim BY-SA 279: Thyroperoxidase, Inhibition
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
602 Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
601 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
600 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
599 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
598 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
597 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell growth You Song BY-SA None None
587 Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1542: Inhibition, Mitochondrial complex III 896: Parkinsonian motor deficits
593 Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons Stefan Schildknecht BY-SA 2362: Redox cycling of a chemical by mitochondria 896: Parkinsonian motor deficits
592 DBDPE-induced DNA strand breaks and LDH activity inhibition leading to population growth rate decline via energy metabolism disrupt and apoptosis lihua Yang BY-SA
591 DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration lihua Yang BY-SA 1194: Increase, DNA damage 2019: Non-alcoholic fatty liver disease
590 Increase of intracellular copper leading to cuproptosis via interference with energy metabolism Sophie Scholz BY-SA 2339: Intracellular copper, increased 2343: Cuproptosis, increased