AOPs

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Showing 476 to 500 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
538 Adverse outcome pathway of PFAS-induced vascular disrupting effects via activating oxidative stress related pathways Yanhong Wei BY-SA None 2161: Increase, Vascular disrupting effects
505 Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway John Frisch BY-SA 1115: Increase, Reactive oxygen species 885: Increase, Cancer
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Jessica Resnick All rights reserved 2158: Influenza A Virus (IAV) binds sialic acid glycan receptor 2194: Influenza A Virus (IAV) shedding and transmission
507 Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
508 Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
509 Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction Yanhong Wei BY-SA 1417: NFE2/Nrf2 repression 2161: Increase, Vascular disrupting effects
548 Activation, Pregnane-X receptor, NR1I2 leads to increased plasma low-density lipoprotein (LDL) cholesterol via increased PCSK9 protein expression John Frisch BY-SA 239: Activation, Pregnane-X receptor, NR1I2 2271: Increased, plasma low-density lipoprotein (LDL) cholesterol
549 Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish Hongling Liu BY-SA 36: Inhibition, Aromatase
550 Increased LMNA gene mutation leading to heart failure Young Jun Kim BY-SA 2278: Increased LMNA Mutation 1535: Heart failure
551 Increased Muscarinic M2 Receptor leading to Arrhythmia Young Jun Kim Open for adoption 1602: Increased Muscarinic Acetylcholine Receptors 1106: Occurrence, cardiac arrhythmia
552 Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) Young Jun Kim BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure
553 Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure Young Jun Kim BY-SA 584: Inhibition, sodium channel 1535: Heart failure
554 β-adrenergic receptor agonists leading to arrhythmias. Young Jun Kim BY-SA 1038: Activation, beta-2 adrenergic receptor 1106: Occurrence, cardiac arrhythmia
519 Cardiac ion channels blockade leading to increased incidence of cardiovascular morbidity and mortality Young Jun Kim Open for adoption 2282: Cardiac ion channels blockade 1929: Increased incidence of cardiovascular morbidity and mortality in the general population
520 Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 341: Impairment, Learning and memory
521 Essential element imbalance leads to reproductive failure via oxidative stress Travis Karschnik BY-SA 2205: Increased, essential element imbalance 2147: Decreased, Viable Offspring
522 Estrogen antagonism leading to increased risk of autism-like behavior Kanglong Cui Open for adoption 112: Antagonism, Estrogen receptor 2209: autism-like behavior
523 Retinoic acid receptor agonism during neurodevelopment leading to microcephaly Diana Lupu Open for adoption 2201: Agonism, Retinoic acid receptor 1978: Increase risk, microcephaly
525 Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory Ellen Fritsche Open for adoption 341: Impairment, Learning and memory
526 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis John Frisch BY-SA None 1758: Impaired, Spermatogenesis
527 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased John Frisch BY-SA None 2082: Hypospadias, increased
471 Neuron defect induced early behavioral change Woo-Keun Kim BY-SA 2195: Increase, CNS Neural cell death
472 DNA adduct formation leading to kidney failure Manoe Janssen BY-SA 373: Formation, Pro-mutagenic DNA Adducts 759: Increased, Kidney Failure
473 Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin Danielle Beaton BY-SA 1686: Deposition of Energy
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang BY-SA