AOPs

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Showing 501 to 525 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
477 Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 2082: Hypospadias, increased
484 Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses Xiaoyun Wu BY-SA None None
485 Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition Eliska Kuchovska BY-SA 1656: Antagonism, Thyroid Receptor 402: Cognitive function, decreased
486 Binding to the extracellular protein laminin leading to decreased cognitive function Eliska Kuchovska BY-SA 2109: Binding, extracellular matrix protein laminin 402: Cognitive function, decreased
487 Unknown MIE altering cholesterol metabolism leading to decreased cognition Eliska Kuchovska BY-SA 1114: Unknown, MIE 402: Cognitive function, decreased
488 Increased reactive oxygen species production leading to decreased cognitive function Eliska Kuchovska BY-SA 1115: Increase, Reactive oxygen species 402: Cognitive function, decreased
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Lidwina Gerner BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased
490 Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms Karine Audouze BY-SA
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira BY-SA 2131: Conjugation, GSH 406: decreased, Fertility
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation 2129: Metabolically unhealthy Obesity
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death
449 Ceramide synthase inhibition leading to neural tube defects Lola Bajard BY-SA 2023: Inhibition of Ceramide Synthase 1561: Neural tube defects
448 ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality Ruiyang Ding BY-SA None None
447 Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways Yann GUEGUEN BY-SA None 759: Increased, Kidney Failure
446 PM-related Adverse outcome pathway frameworks on various systems Tianyu Li BY-SA None None
445 Estrogen Receptor Alpha Agonism leads to Impaired Reproduction John Hoang BY-SA 1065: Activation, estrogen receptor alpha 1991: Impaired, Reproduction
444 Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability Deborah Oughton BY-SA 360: Decrease, Population growth rate
441 Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation Olivier ARMANT BY-SA 1686: Deposition of Energy 1978: Increase risk, microcephaly
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang BY-SA None None
436 Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries Gina Mennen BY-SA 1880: Decreased, ALDH1A (RALDH) enzyme activity 1970: transposition of the great arteries
435 Deposition of ionising energy leads to population decline via pollen abnormal Li Xie BY-SA 1686: Deposition of Energy
434 CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects Job Berkhout BY-SA None None
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu BY-SA None 1250: Decrease, Lung function
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede BY-SA 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang BY-SA 1950: Increase, TNF 1953: Gestational diabetes mellitus