AOPs

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Showing 551 to 575 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
644 Bulky DNA adducts leading to chromosomal aberrations and mutations Beckner Andersano BY-SA 1879: Bulky DNA adducts, increase
622 Calcineurin inhibitor induced nephrotoxicity leading to kidney failure Kate Liang BY-SA None 759: Increased, Kidney Failure
623 Activation, estrogen receptor alpha leads to persistent vaginal cornification via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2306: Persistent vaginal cornification
624 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
625 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
13 Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities Anna Price BY-SA 201: Binding of antagonist, NMDA receptors 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.22
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk BY-SA 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring WPHA/WNT Endorsed 1.11
16 Acetylcholinesterase inhibition leading to acute mortality Dan Villeneuve BY-SA 12: Acetylcholinesterase (AchE) Inhibition Under Development 1.3
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
506 Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation Jessica Resnick All rights reserved 2158: Influenza A Virus (IAV) binds sialic acid glycan receptor 2194: Influenza A Virus (IAV) shedding and transmission
547 Androgen receptor agonism leading to long anogenital distance in female offspring Johanna Zilliacus All rights reserved 25: Agonism, Androgen receptor 2365: Anogenital distance (AGD), increased
379 Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation Shihori Tanabe All rights reserved 1739: Binding to ACE2 1846: Thrombosis and Disseminated Intravascular Coagulation Under Development 1.96
475 Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons Shihori Tanabe All rights reserved 875: Binding of agonist, Ionotropic glutamate receptors 341: Impairment, Learning and memory Under Development 1.107
607 Per and Polyfluoro Alkylating Substances and Microbiota-Gut-Brain Axis Dhirendra Pratap Singh All rights reserved None None
608 Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination Ki-Tae Kim All rights reserved None None
610 Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function Nathalie Dierichs All rights reserved
615 Suppression of Keap1 cysteine oxidation leading to liver inflammation Young Jun Kim All rights reserved 2385: Suppression of Keap1 cysteine oxidation 902: Inflammation, Liver
616 organic UV filter and its Photoproducts reproductive toxicity pathways Nataraj Bojan All rights reserved 2391: Reduced fertility / fecundity
617 The adverse outcome pathway of vascular calcification Ruiyang Ding All rights reserved None None
620 The Adverse Outcome Pathway to Deposition of Energy Leading to Female Decreased Fertility Jessica D'Urbano All rights reserved None None
595 Emerging OPFRS reproductive outcome pathway Shahena Perveen All rights reserved
594 Micro plastic effect on reproduction Shahena Perveen All rights reserved 1238: Activation of oxidative stress pathway 1277: Reproductive failure
604 Binding of Alpha 1-Adrenergics to Agonists Leading to Depression LUANA GOMES All rights reserved 2370: Agonism binding, α1-Adrenoreceptor 1346: Increased, depression