AOPs

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Showing 551 to 575 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
169 GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. Charles Wood BY-SA None 1082: Increased, adenomas (pituitary)
170 Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat Charles Wood BY-SA None 1079: Increased, Adenomas/carcinomas (mammary)
171 Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. Charles Wood BY-SA None 1090: Increased, mesotheliomas
163 PPARgamma activation leading to sarcomas in rats, mice, and hamsters Charles Wood BY-SA 1028: Activation of specific nuclear receptors, PPAR-gamma activation None
176 Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis Jonathan Haselman BY-SA 424: Inhibition, Na+/I- symporter (NIS) 1101: Altered, Amphibian metamorphosis
177 Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 1103: Inhibition, Cyclooxygenase 1 activity
178 Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony
179 Varroa mite infestation increases virus levels leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
180 Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
181 Weather event contributes to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
182 Weather event contributes abnormal foraging leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
183 Nosema infection increases energetic demands leading to colony loss/failure Carlie LaLone BY-SA None 563: Death/Failure, Colony
211 Handbook development AOP Dan Villeneuve BY-SA None None
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA 798: Inhibition, Prolyl hydroxylases
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood BY-SA None 741: Increase, Adenomas/carcinomas (follicular cell)
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Undefined BY-SA 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol 972: Decreased fertility, Reduced number of oocytes ovulated
146 Estrogen Receptor Activation and Female Precocious Puberty Undefined Open for adoption None None
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 877: Inhibition, organic anion transporter 1 (OAT1)
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert BY-SA 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive function, decreased
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Undefined BY-SA 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood BY-SA 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar)
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)
120 Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) Charles Wood BY-SA 1617: Inhibition, 5α-reductase 745: Increase, Leydig cell tumors