AOPs

OECD View API
Toggle for API info
The API endpoint defaults to 25 results per page, but you can adjust this by changing the per_page parameter in the URL.
Searches both title and fulltext content
Takes you to the requested AOP
Clear Search Terms Clears search terms and filters

Showing 51 to 75 of 584 AOPs

Clear Table Filters
ID Title Point of Contact License MIE AO OECD Status OECD Project
297 Inhibition of retinaldehyde dehydrogenase leads to population decline Young Jun Kim BY-SA 1637: Retinaldehyde dehydrogenase inhibition 360: Decrease, Population growth rate Under Development 1.77
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
313 Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease Hiroyuki Komatsu BY-SA 1706: Stimulation, TLR7/8 1709: Psoriatic skin disease Under Development 1.75
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
314 Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE) Yasuharu Otsubo BY-SA 1710: Binding to estrogen receptor (ER)-α in immune cells 1714: Exacerbation of systemic lupus erythematosus (SLE) Under Development 1.73
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7
41 Sustained AhR Activation leading to Rodent Liver Tumours Undefined BY-SA 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Under Review 1.7
131 Aryl hydrocarbon receptor activation leading to uroporphyria Amani Farhat BY-SA 18: Activation, AhR 369: Uroporphyria WPHA/WNT Endorsed 1.7
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
43 Disruption of VEGFR Signaling Leading to Developmental Defects Undefined BY-SA 305: Inhibition, VegfR2 1001: Increased, Developmental Defects WPHA/WNT Endorsed 1.6
271 Inhibition of thyroid peroxidase leading to impaired fertility in fish June-Woo Park BY-SA 279: Thyroperoxidase, Inhibition 78: Reduction, Cumulative fecundity and spawning Under Development 1.59
298 Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer Shihori Tanabe BY-SA 1115: Increase, Reactive oxygen species 1651: Treatment-resistant gastric cancer Under Review 1.58
272 Deposition of energy leading to lung cancer Vinita Chauhan BY-SA 1686: Deposition of Energy 1556: Increase, lung cancer WPHA/WNT Endorsed 1.56
237 Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response Ulla Vogel BY-SA 1495: Substance interaction with the lung resident cell membrane components 1443: Atherosclerosis Under Development 1.55
206 Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis Jinhee Choi BY-SA 1270: Inactivation of PPARγ 1276: Lung fibrosis Under Development 1.54
202 Inhibitor binding to topoisomerase II leading to infant leukaemia Andrea Terron BY-SA 1252: Binding to (interferes with) topoisomerase II enzyme 1254: Infant leukaemia WPHA/WNT Endorsed 1.53
212 Histone deacetylase inhibition leading to testicular atrophy Shihori Tanabe BY-SA 1502: Histone deacetylase inhibition 1506: Testicular atrophy WPHA/WNT Endorsed 1.52
148 EGFR Activation Leading to Decreased Lung Function Karsta Luettich BY-SA 941: Activation, EGFR 1250: Decrease, Lung function Under Development 1.51
149 Peptide Oxidation Leading to Hypertension Frazer Lowe BY-SA 209: Peptide Oxidation 952: Hypertension Under Development 1.50
282 Adverse outcome pathway on photochemical toxicity initiated by light exposure Satomi Onoue BY-SA 1115: Increase, Reactive oxygen species 1599: Inflamatory events in light-exposed tissues Under Review 1.49
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga BY-SA 1700: Impaired IL-1R1 signaling in T cell 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.48
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA 1539: Endocytotic lysosomal uptake 344: Increase, Liver fibrosis Under Review 1.47
261 L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility Luigi Margiotta-Casaluci BY-SA 1529: Blockade, L-Type Calcium Channels 1535: Heart failure Under Development 1.45
262 L-type calcium channel blockade leading to the disruption of cardiac electrophysiology Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45
283 L-type calcium channel blockade leading to hypotension Luigi Margiotta-Casaluci BY-SA None None Under Development 1.45