AOPs

OECD View API
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Showing 51 to 75 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
439 Activation of the AhR leading to metastatic breast cancer Louise Benoit BY-SA 18: Activation, AhR 1982: metastatic breast cancer Under Review 1.105
46 AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC) Ted Simon BY-SA 373: Formation, Pro-mutagenic DNA Adducts 378: Tumorigenesis, Hepatocellular carcinoma Under Review 1.8
18 PPARα activation in utero leading to impaired fertility in males Elise Grignard BY-SA 227: Activation, PPARα Under Review 1.21
30 Estrogen receptor antagonism leading to reproductive dysfunction Dan Villeneuve BY-SA 112: Antagonism, Estrogen receptor 360: Decrease, Population growth rate Under Review 1.12
136 Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors Undefined BY-SA 867: Decrease, Intracellular pH 872: Increase, Site of Contact Nasal Tumors Under Review 2.7
144 Endocytic lysosomal uptake leading to liver fibrosis Marina Kuburic BY-SA 1539: Endocytotic lysosomal uptake 344: Increase, Liver fibrosis Under Review 1.47
41 Sustained AhR Activation leading to Rodent Liver Tumours Undefined BY-SA 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Under Review 1.7
106 Chemical binding to tubulin in oocytes leading to aneuploid offspring Francesco Marchetti BY-SA 718: Binding, Tubulin 728: Increase, Aneuploid offspring Under Review 1.11
107 Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat Kristin Lichti-Kaiser BY-SA 715: Activation, Constitutive androstane receptor 719: Increase, hepatocellular adenomas and carcinomas Under Review 1.17
524 Gluten-driven immune activation leading to celiac disease in genetically predisposed individuals Antonio Fernandez Dumont BY-SA 2257: Celiac disease Under Review 1.98
503 Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation Barbara Viviani BY-SA 1065: Activation, estrogen receptor alpha 2154: Uterine adenocarcinoma (endometrioid adenocarcinoma Type I) Under Review 1.100
348 Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory Young Jun Kim BY-SA 1799: Inhibition of 11β-HSD 360: Decrease, Population growth rate Under Development 1.93
349 Inhibition of 11β-hydroxylase leading to decresed population trajectory Young Jun Kim BY-SA 1796: 11β-hydroxylase inhibition 360: Decrease, Population growth rate Under Development 1.93
358 Chitinase inhibition leading to mortality Simon Schmid BY-SA 1806: Inhibition, Chitinase 350: Increase, Mortality Under Development 1.94
359 Chitobiase inhibition leading to mortality Simon Schmid BY-SA 1807: Inhibition, Chitobiase 350: Increase, Mortality Under Development 1.94
361 Sulfonylureareceptor binding leading to mortality Simon Schmid BY-SA 1525: Increase, Sulfonylurea receptor binding 350: Increase, Mortality Under Development 1.94
364 Thyroperoxidase inhibition leading to altered visual function via decreased eye size Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
365 Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning Lucia Vergauwen All rights reserved 279: Thyroperoxidase, Inhibition Under Development 1.35
294 Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer Jessica Helm BY-SA 1632: Increase in reactive oxygen and nitrogen species (RONS) Under Development 1.80
295 Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk Andrea Hindman BY-SA None None Under Development 1.79
316 Trypsin inhibition leading to pancreatic acinar cell tumors Shigeru Hisada BY-SA 1720: Trypsin inhibition 1725: Pancreatic acinar cell tumors Under Development 1.60
319 Binding to ACE2 leading to lung fibrosis Young Jun Kim BY-SA 1740: Induced dysregulation of ACE2 1276: Lung fibrosis Under Development 1.96
320 Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality Young Jun Kim BY-SA 1739: Binding to ACE2 351: Increased Mortality Under Development 1.96
344 Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring Terje Svingen BY-SA 26: Antagonism, Androgen receptor 1786: Nipple retention (NR), increased Under Development 1.108
345 Androgen receptor (AR) antagonism leading to decreased fertility in females Terje Svingen BY-SA 26: Antagonism, Androgen receptor Under Development 1.109