AOPs

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Showing 101 to 125 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
489 Inhibition of voltage-gated sodium channels leading to decreased cognition Lidwina Gerner BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased
490 Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms Karine Audouze BY-SA
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira BY-SA 2131: Conjugation, GSH 406: decreased, Fertility
493 ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity Min Ji Kim BY-SA 2126: Estrogen receptor alpha inactivation 2129: Metabolically unhealthy Obesity
461 Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis Knut Erik Tollefsen BY-SA None None
462 Activation of reactive oxygen species leading the atherosclerosis Hiromi Ohara BY-SA 1115: Increase, Reactive oxygen species None
463 The AOP framwork on silica nanopariticles induced hepatoxicity Tianyu Li BY-SA None None
464 Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits Julia Meerman BY-SA 896: Parkinsonian motor deficits
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
468 Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) Laure-Alix Clerbaux BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
469 Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population Ruiyang Ding BY-SA None None
122 Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation Dalma Martinovic-Weigelt BY-SA 798: Inhibition, Prolyl hydroxylases
162 Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse Charles Wood BY-SA None 741: Increase, Adenomas/carcinomas (follicular cell)
161 Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality Knut Erik Tollefsen BY-SA 1018: Activation, Glutamate-gated chloride channels 351: Increased Mortality
160 Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality Knut Erik Tollefsen BY-SA 762: Activation, ionotropic GABA Receptor chloride channel 351: Increased Mortality
153 Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats Undefined BY-SA 964: Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol 972: Decreased fertility, Reduced number of oocytes ovulated
138 Organic anion transporter (OAT1) inhibition leading to renal failure and mortality Kellie Fay BY-SA 877: Inhibition, organic anion transporter 1 (OAT1)
134 Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals Mary Gilbert BY-SA 424: Inhibition, Na+/I- symporter (NIS) 402: Cognitive function, decreased
126 Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation Undefined BY-SA 849: Inhibition, Antgonism of NE receptor 527: Decreased, Decreased fecundity
124 HMG-CoA reductase inhibition leading to decreased fertility Kellie Fay BY-SA 804: Inhibition, HMG-CoA reductase 330: Decrease, Fertility
123 Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription Dalma Martinovic-Weigelt BY-SA 801: modulation, Unknown
109 Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse) Charles Wood BY-SA 770: Increase, Cytotoxicity (club cells) 736: Increase, Adenomas/carcinomas (bronchioloalveolar)
121 Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) Charles Wood BY-SA 793: Increase, Urinary bladder calculi 797: Increase, Adenomas/carcinomas (urothelial)