AOPs

OECD View API
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Showing 126 to 150 of 558 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
335 AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment Nathalia Pereira Souza BY-SA 177: Increase, Mitochondrial dysfunction 1763: Urothelial Tumor
332 Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
333 Reactive oxygen species leading to growth inhibition via protein oxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
338 DNA methyltransferase inhibition leading to population decline (3) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
325 Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
326 Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
327 Excessive reactive oxygen species production leading to mortality (1) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
328 Excessive reactive oxygen species production leading to mortality (2) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
329 Excessive reactive oxygen species production leading to mortality (3) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
330 Excessive reactive oxygen species production leading to mortality (4) You Song BY-SA 1115: Increase, Reactive oxygen species 350: Increase, Mortality
343 Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade You Song BY-SA 2374: Increase, Ecdysone receptor antagonism
371 Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone You Song BY-SA None None
369 Photosystem II antagonism leading to growth inhibition via oxidative damage You Song BY-SA None None
342 Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade You Song BY-SA 103: Increase, Ecdysone receptor hyperactivation
370 Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis You Song BY-SA None None
331 Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
324 Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
311 Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis You Song BY-SA 1686: Deposition of Energy
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92
264 Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
265 Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
266 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
267 Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
268 Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth Under Development 1.92
614 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor You Song BY-SA 227: Activation, PPARĪ± 947: Increase, Early Life Stage Mortality