AOPs

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Showing 151 to 175 of 558 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
596 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
597 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell growth You Song BY-SA None None
598 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
599 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
600 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
601 Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
602 Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
603 Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption You Song BY-SA 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
613 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
612 Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate You Song BY-SA 227: Activation, PPARα 947: Increase, Early Life Stage Mortality
606 Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1 You Song BY-SA 2374: Increase, Ecdysone receptor antagonism
624 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
625 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
627 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
628 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
629 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
630 Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2409: Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity None Under Development
631 Decreased thyroid hormone receptor beta transcriptional activity leading to MASLD progression via endoplasmic reticulum stress You Song BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) You Song BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) You Song BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) You Song BY-SA None None
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) You Song BY-SA None None
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition