AOPs

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Showing 176 to 200 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
108 Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood BY-SA 724: Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme 719: Increase, hepatocellular adenomas and carcinomas
58 NR1I3 (CAR) suppression leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
479 Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress Sivakumar Murugadoss BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
480 Mitochondrial complexes inhibition leading to heart failure via decreased ATP production Alexandra Schaffert BY-SA 105: Inhibition, Mitochondrial Electron Transport Chain Complexes 2215: Decrease Left Ventricular function Under Development 1.102
491 Decrease, GLI1/2 target gene expression leads to orofacial clefting Jacob Reynolds BY-SA 2040: Decrease, GLI1/2 target gene expression 2042: Increase, Orofacial clefting Under Development 1.101
502 Decrease, cholesterol synthesis leads to orofacial clefting Jacob Reynolds BY-SA None 2042: Increase, Orofacial clefting Under Development 1.101
4 Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 Knut Erik Tollefsen BY-SA 103: Increase, Ecdysone receptor hyperactivation
28 Cyclooxygenase inhibition leading reproductive failure Dan Villeneuve BY-SA 79: Inhibition, Cyclooxygenase activity 253: N/A, Reproductive failure
29 Estrogen receptor agonism leading to reproductive dysfunction Undefined BY-SA 111: Agonism, Estrogen receptor
32 Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors Undefined BY-SA None None
34 LXR activation leading to hepatic steatosis Undefined BY-SA 345: N/A, Liver Steatosis
36 Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
52 ER agonism leading to skewed sex ratios due to altered sexual differentiation in males Undefined BY-SA 111: Agonism, Estrogen receptor 417: skewed, sex ratio
53 ER agonism leading to reduced survival due to renal failure Undefined BY-SA 111: Agonism, Estrogen receptor None
57 AhR activation leading to hepatic steatosis Michelle Angrish BY-SA 18: Activation, AhR 459: Increase, Liver steatosis
73 Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity Undefined BY-SA 526: Inhibition, Inhibition of Dopamine-beta-hydroxylase 527: Decreased, Decreased fecundity
59 HNF4alpha suppression leading to hepatic steatosis Michelle Angrish BY-SA 461: Suppression, HNF4alpha None
60 NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis Michelle Angrish BY-SA 245: Activation, PXR/SXR 459: Increase, Liver steatosis
61 NFE2L2/FXR activation leading to hepatic steatosis Michelle Angrish BY-SA 459: Increase, Liver steatosis
62 AKT2 activation leading to hepatic steatosis Michelle Angrish BY-SA 486: systemic inflammation leading to hepatic steatosis 459: Increase, Liver steatosis
63 Cyclooxygenase inhibition leading to reproductive dysfunction Dalma Martinovic-Weigelt BY-SA 79: Inhibition, Cyclooxygenase activity
64 Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility Undefined BY-SA 494: Glucocorticoid Receptor Agonist, Activation 406: decreased, Fertility
66 Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
67 Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis Undefined BY-SA 505: Decreased sperm quantity / quality in the adult, Decreased fertility
68 Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome Undefined BY-SA 661: Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome 505: Decreased sperm quantity / quality in the adult, Decreased fertility