AOPs

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Showing 201 to 225 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
69 Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell Undefined BY-SA 646: Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
70 Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell Undefined BY-SA 640: Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell 520: Decreased sperm quantity or quality in the adult, Decreased fertility
71 Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation Undefined BY-SA 650: Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid 520: Decreased sperm quantity or quality in the adult, Decreased fertility
239 Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling Undefined BY-SA None None
287 Mitochondrial complex III antagonism leading to growth inhibition (2) You Song BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth
286 Mitochondrial complex III antagonism leading to growth inhibition (1) You Song BY-SA 1542: Inhibition, Mitochondrial complex III 1521: Decrease, Growth
240 DNA Adducts Leading to Liver Hemangiosarcoma Undefined BY-SA None None
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
290 Mitochondrial ATP synthase antagonism leading to growth inhibition (1) You Song BY-SA 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
291 Mitochondrial ATP synthase antagonism leading to growth inhibition (2) You Song BY-SA 1785: Increase, Mitochondrial ATP synthase antagonism 1521: Decrease, Growth
299 Deposition of energy leading to population decline via DNA oxidation and follicular atresia You Song BY-SA 1686: Deposition of Energy
336 DNA methyltransferase inhibition leading to population decline (1) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
337 DNA methyltransferase inhibition leading to population decline (2) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
339 DNA methyltransferase inhibition leading to population decline (4) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
340 DNA methyltransferase inhibition leading to transgenerational effects (1) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
205 AOP from chemical insult to cell death Mathieu Vinken BY-SA
236 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
235 Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening Timothy Allen BY-SA 1431: Serotonin 1A Receptor Agonism 1432: Anti-depressant Activity
234 Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
233 Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening Timothy Allen BY-SA 1425: Mu Opioid Receptor Agonism 1428: Analgesia
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
211 Handbook development AOP Dan Villeneuve BY-SA None None
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi BY-SA None 1277: Reproductive failure