AOPs

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Showing 201 to 225 of 594 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
433 hERG channel blockade leading to sudden cardiac death Egemen Bilgin BY-SA 2099: hERG channel blockade 1964: Sudden cardiac death
432 Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia Dag Anders Brede BY-SA 1686: Deposition of Energy 1955: Acute Myeloid Leukemia
431 Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM) Qi Wang BY-SA 1950: Increase, TNF 1953: Gestational diabetes mellitus
429 A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants Erwin L Roggen BY-SA None 1941: Memory Loss
427 ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1535: Heart failure
426 SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. Evangelos-Panagiotis Daskalopoulos BY-SA 1739: Binding to ACE2 1934: Myocardial Infarction
425 Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1 Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
424 Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
409 Frustrated phagocytosis leads to malignant mesothelioma Penny Nymark BY-SA 1668: Frustrated phagocytosis 1090: Increased, mesotheliomas
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu BY-SA None 1250: Decrease, Lung function
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu BY-SA None None
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1276: Lung fibrosis
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
413 Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure Carmel Mothersill BY-SA 926: Oxidation, Glutathione (To be considered with MIE) 351: Increased Mortality
411 Oxidative stress Leading to Decreased Lung Function Karsta Luettich BY-SA 1392: Increase, Oxidative Stress 1250: Decrease, Lung function
410 GSK3beta inactivation leading to increased mortality via defects in developing inner ear Vid Modic BY-SA 1647: GSK3beta inactivation
385 Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation Julija Filipovska BY-SA 1739: Binding to ACE2 None
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1967: Pyroptosis
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
405 Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function SAROJ AMAR BY-SA 12: Acetylcholinesterase (AchE) Inhibition 402: Cognitive function, decreased
400 Inhibition of CYP26B1 activity in fetal testis leading to reduced fertility Terje Svingen BY-SA 1887: Inhibition of CYP26B1 activity 406: decreased, Fertility
399 Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) Vid Modic BY-SA 1884: Inhibition of Fyna