AOPs

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Showing 201 to 225 of 584 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
339 DNA methyltransferase inhibition leading to population decline (4) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
340 DNA methyltransferase inhibition leading to transgenerational effects (1) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
341 DNA methyltransferase inhibition leading to transgenerational effects (2) You Song BY-SA 1619: Increase, DNA methyltransferase inhibition
217 Gastric ulcer formation Lyle Burgoon Open for adoption None
207 NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans Jinhee Choi BY-SA 1174: Activation, NADPH Oxidase 1277: Reproductive failure
208 Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure Jinhee Choi BY-SA None 1277: Reproductive failure
209 Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP Jinhee Choi BY-SA None 1291: Hepatotoxicity
210 Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building Jinhee Choi BY-SA None 1277: Reproductive failure
211 Handbook development AOP Dan Villeneuve BY-SA None None
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption None
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption None
216 Deposition of energy leading to population decline via DNA strand breaks and follicular atresia Knut Erik Tollefsen BY-SA 1686: Deposition of Energy
205 AOP from chemical insult to cell death Mathieu Vinken BY-SA
218 Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
219 Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior Florence Pagé-Larivière BY-SA 1386: CYP7B activity, inhibition 360: Decrease, Population growth rate
221 Mental stress to depression Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
222 Mental stress to agitation Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1344: Increased, seizure
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1346: Increased, depression
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption None 1345: Increased, agitation
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
90 Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor
77 Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 Carlie LaLone BY-SA 559: Activation, Nicotinic acetylcholine receptor 563: Death/Failure, Colony