AOPs

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Showing 1 to 25 of 555 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
581 Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease Marie-Gabrielle Zurich All rights reserved 122: Increase, Glucocorticoid receptor activation 402: Cognitive function, decreased
547 Androgen receptor agonism leading to long anogenital distance in female offspring Johanna Zilliacus All rights reserved 25: Agonism, Androgen receptor 2365: Anogenital distance (AGD), increased
476 Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity Yue Zhang BY-SA
414 Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
415 Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1276: Lung fibrosis
416 Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
417 Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway Dianke Yu BY-SA 18: Activation, AhR 1670: Lung cancer
418 Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway Dianke Yu BY-SA None None
419 Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway Dianke Yu BY-SA None 1250: Decrease, Lung function
420 Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway Dianke Yu BY-SA 18: Activation, AhR None
315 Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response Yasuhiro Yoshida BY-SA 1715: Inhibition of JAK3 1719: Impairment of T-cell dependent antibody response Under Development 1.74
347 Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis Seokjoo Yoon BY-SA 1458: Pulmonary fibrosis
465 Alcohol dehydrogenase leading to reproductive dysfunction Donggon Yoo BY-SA 2045: Increase, Alcohol dehydrogenase None
466 Doda decarboxylase leading to mortality Donggon Yoo BY-SA 2051: Decrease, Tyrosine None
467 Knickkopf leading to mortality Donggon Yoo BY-SA 2058: Decrease, 20-hydroxyecdysone None
611 Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes Donggon Yoo BY-SA 2379: Disruption of the regulatory function of dopamine signaling components. 2382: Increase, nerve spasm
406 SARS-CoV-2 infection leading to hyperinflammation Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1868: Hyperinflammation
407 SARS-CoV-2 infection leading to pyroptosis Hasmik Yepiskoposyan BY-SA 1739: Binding to ACE2 1967: Pyroptosis
322 Alkylation of DNA leading to reduced sperm count Carole Yauk BY-SA 97: Alkylation, DNA 1757: Reduce, Sperm count
397 Bulky DNA adducts leading to mutations Carole Yauk BY-SA 1879: Bulky DNA adducts, increase 185: Increase, Mutations Under Development 1.11
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption 97: Alkylation, DNA 885: Increase, Cancer
15 Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations Carole Yauk BY-SA 97: Alkylation, DNA 336: Increase, Heritable mutations in offspring WPHA/WNT Endorsed 1.11
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
438 reactive oxygen species generation leading to increased cardiovascular morbidity and mortality Yu Yang BY-SA None None