AOPs

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Showing 1 to 25 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
217 Gastric ulcer formation Lyle Burgoon Open for adoption None
228 NSAID induced PTGS2 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1408: Reduced, PTGS2 function 1385: Activated, gastric ulcer formation
227 NSAID induced PTGS1 inactivation to gastric ulcer Lyle Burgoon Open for adoption 1402: Reduced, PTGS1 function 1385: Activated, gastric ulcer formation
226 SSRI (Selective serotonin reuptake inhibitor) to hypertension Lyle Burgoon Open for adoption 1317: Decreased, serotonin transporter activity 1343: Increase, hypertension
225 Serotonin transporter activation to agitation Lyle Burgoon Open for adoption None 1345: Increased, agitation
224 Serotonin transporter activation to depression Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1346: Increased, depression
223 Serotonin transporter activation to seizure Lyle Burgoon Open for adoption 1397: Increased, serotonin transporter activity 1344: Increased, seizure
222 Mental stress to agitation Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1345: Increased, agitation
221 Mental stress to depression Lyle Burgoon Open for adoption 1396: Increased, glucocorticoid receptor activity 1346: Increased, depression
229 Helicobacter pylori to gastric ulcer Lyle Burgoon Open for adoption 1412: Helicobacter pylori infection 1385: Activated, gastric ulcer formation
230 presynaptic neuron 1 activation to epilepsy Lyle Burgoon Open for adoption 1349: Activated, presynaptic neuron 1 1363: Increased, epilepsy
231 presynaptic neuron 2 repression to epilepsy Lyle Burgoon Open for adoption 1413: Reduced, presynaptic neuron 2 activity 1363: Increased, epilepsy
215 Molecular events lead to epilepsy Lyle Burgoon Open for adoption None
214 Network of SSRIs (selective serotonin reuptake inhibitors) Lyle Burgoon Open for adoption None
213 Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) Lyle Burgoon Open for adoption 1490: Inhibition, Fatty Acid Beta Oxidation 1489: Increase, Steatohepatitis
232 NFE2/Nrf2 repression to steatosis Lyle Burgoon Open for adoption 1417: NFE2/Nrf2 repression 459: Increase, Liver steatosis
200 Estrogen receptor activation leading to breast cancer Molly M Morgan Open for adoption 111: Agonism, Estrogen receptor 1193: N/A, Breast Cancer
146 Estrogen Receptor Activation and Female Precocious Puberty Undefined Open for adoption None None
139 Alkylation of DNA leading to cancer 1 Carole Yauk Open for adoption 97: Alkylation, DNA 885: Increase, Cancer
19 Androgen receptor antagonism leading to adverse effects in the male foetus (mammals) Mukesh Patel Open for adoption 26: Antagonism, Androgen receptor 337: N/A, Impairment of reproductive capacity
26 Calcium-mediated neuronal ROS production and energy imbalance Lyle Burgoon Open for adoption 51: Inhibition, Ca++ ATPase 1392: Increase, Oxidative Stress
33 Kidney toxicity induced by activation of 5HT2C Kevin Crofton Open for adoption 9: Activation, 5HT2c 759: Increased, Kidney Failure
117 Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) Charles Wood Open for adoption 25: Agonism, Androgen receptor 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.26
621 NOX2 Driven Oxidative Stress-Induced α-Synuclein Radical Formation and Tau Nitration Leading to Neurodegeneration Tejasvi kumar Open for adoption None None
459 AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals Prakash Patel Open for adoption 18: Activation, AhR 402: Cognitive function, decreased