AOPs

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Showing 1 to 25 of 581 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
455 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development Prarthana Shankar BY-SA 18: Activation, AhR WPHA/WNT Endorsed 1.27
456 Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity Prarthana Shankar BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.27
442 Binding to voltage gate sodium channels during development leads to cognitive impairment Iris Mangas BY-SA 1353: Binding to voltage-gated sodium channel 402: Cognitive function, decreased WPHA/WNT Endorsed 1.91
376 Androgen receptor agonism leading to male-biased sex ratio Dan Villeneuve BY-SA 25: Agonism, Androgen receptor 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
346 Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation Kelvin Santana Rodriguez BY-SA 36: Inhibition, Aromatase 360: Decrease, Population growth rate WPHA/WNT Endorsed 1.12
360 Chitin synthase 1 inhibition leading to mortality Simon Schmid BY-SA 1522: Inhibition, Chitin synthase 1 350: Increase, Mortality WPHA/WNT Endorsed 1.94
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
277 Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response Takao Ashikaga BY-SA 1700: Impaired IL-1R1 signaling in T cell 984: Impairment, T-cell dependent antibody response WPHA/WNT Endorsed 1.48
263 Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation You Song BY-SA 1446: Decrease, Coupling of oxidative phosphorylation 1521: Decrease, Growth WPHA/WNT Endorsed 1.92
272 Deposition of energy leading to lung cancer Vinita Chauhan BY-SA 1686: Deposition of Energy 1556: Increase, lung cancer WPHA/WNT Endorsed 1.56
3 Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits Andrea Terron BY-SA 888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) 896: Parkinsonian motor deficits WPHA/WNT Endorsed 1.33
6 Antagonist binding to PPARĪ± leading to body-weight loss Kurt A. Gust BY-SA 998: Binding of antagonist, PPAR alpha 864: Decreased, Body Weight WPHA/WNT Endorsed 2.3
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
220 Cyp2E1 Activation Leading to Liver Cancer Francina Webster BY-SA 1391: Activation of Cyp2E1 1395: Liver Cancer WPHA/WNT Endorsed 1.24
155 Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
156 Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 1002: Inhibition, Deiodinase 2 WPHA/WNT Endorsed 1.35
157 Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation Dries Knapen BY-SA 1009: Inhibition, Deiodinase 1 WPHA/WNT Endorsed 1.35
158 Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 1009: Inhibition, Deiodinase 1 WPHA/WNT Endorsed 1.35
159 Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation Dries Knapen BY-SA 279: Thyroperoxidase, Inhibition WPHA/WNT Endorsed 1.35
173 Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis Sabina Halappanavar BY-SA 1495: Substance interaction with the lung resident cell membrane components 1458: Pulmonary fibrosis WPHA/WNT Endorsed 1.32
54 Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment Anna Price BY-SA 424: Inhibition, Na+/I- symporter (NIS) 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.28
150 Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF Amani Farhat BY-SA 18: Activation, AhR 947: Increase, Early Life Stage Mortality WPHA/WNT Endorsed 1.7