{"id":17,"title":"Network of Reactive Oxygen Species (ROS)","purpose":"AOPs linked with ROS-related KEs discussed at the Mystery of ROS consortium are collected. \r\nRef. 1: Tanabe S, Beaton D, Chauhan V, Choi I, Danielsen PH, Delrue N, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant TW, Garcia-Reyero N, Helm JS, Huliganga E, Jacobsen NR, Kay JE, Kim YJ, Klose J, La Rocca C, Luettich K, Mally A, O'Brien J, Poulsen SS, Rudel RA, Sovadinova I, Tollefsen KE, Vogel U, Yepiskoposyan H, Yauk C. Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences. ALTEX. 2022;39(2):336-338. doi: 10.14573/altex.2203011. PMID: 37470453.\r\nRef. 2: Tanabe S, O'Brien J, Tollefsen KE, Kim Y, Chauhan V, Yauk C, Huliganga E, Rudel RA, Kay JE, Helm JS, Beaton D, Filipovska J, Sovadinova I, Garcia-Reyero N, Mally A, Poulsen SS, Delrue N, Fritsche E, Luettich K, La Rocca C, Yepiskoposyan H, Klose J, Danielsen PH, Esterhuizen M, Jacobsen NR, Vogel U, Gant TW, Choi I, FitzGerald R. Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events. Front Toxicol. 2022 Jul 6;4:887135. doi: 10.3389/ftox.2022.887135. PMID: 35875696; PMCID: PMC9298159.\r\nRef. 3: Tanabe S, Beaton D, Chauhan V, Choi I, Choi J, Clerbaux LA, Coppola L, Dumont AF, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Garcia-Reyero N, Goralczyk A, Huliganga E, Kim YJ, Klose J, La Rocca C, Landesmann B, Mally A, Murugadoss S, Omeragic E, Ouédraogo G, Pereira JM, Sadi B, Schaffert A, Song Y, Sovadinova I, Stöger T, Tollefsen KE, Wittwehr C, Yauk C. Report of the 3rd and 4th Mystery of Reactive Oxygen Species Conference. ALTEX. 2023;40(4):689-693. doi: 10.14573/altex.2307041. PMID: 37889188.\r\nRef. 4: Tanabe S, Beaton D, Becker RA, Chauhan V, Choi J, Choi E, Cole A, Cooke MS, Coppola L, Esterhuizen M, Filipovska J, FitzGerald R, Fritsche E, Gant TW, Gayen K, Hajizadeh N, Hamada N, Hench VK, Huzain O, Karschnik T, Katsiadaki I, Kim YJ, La Rocca C, Mally A, Omeragic E, Ouédraogo G, Reyero N, Schaffert A, Song Y, Sovadinova I, Tao R, Tsukano M, Villeneuve D, Vogel U, Yauk CL. Report on the 5th and 6th Mystery of Reactive Oxygen Species Conferences. ALTEX. 2026;43(2):353-358. doi: 10.14573/altex.2512041. PMID: 41982194.","creation_strategy":"AOPs are listed based on Figure 1 in Reference 1 (Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences. ALTEX. 2022;39(2):336-338. doi: 10.14573/altex.2203011.)","creation_strategy_notes":"AOPs are listed based on Figure 1 in Reference 1 (Report of the 1st and 2nd Mystery of Reactive Oxygen Species Conferences. ALTEX. 2022;39(2):336-338. doi: 10.14573/altex.2203011.)","collection_type":"aop","status":"submitted","creator_id":355,"submitted_at":"2026-08-19T21:17:01.000-04:00","approved_at":null,"rejected_at":null,"contributors":[],"item_count":15,"items":[{"id":293,"title":"Increased DNA damage leading to increased risk of breast cancer"},{"id":294,"title":"Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer"},{"id":296,"title":"Oxidative DNA damage leading to chromosomal aberrations and mutations"},{"id":298,"title":"Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer"},{"id":299,"title":"Deposition of energy leading to population decline via DNA oxidation and follicular atresia"},{"id":327,"title":"Excessive reactive oxygen species production leading to mortality (1)"},{"id":328,"title":"Excessive reactive oxygen species production leading to mortality (2)"},{"id":329,"title":"Excessive reactive oxygen species production leading to mortality (3)"},{"id":330,"title":"Excessive reactive oxygen species production leading to mortality (4)"},{"id":379,"title":"Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation"},{"id":382,"title":"Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis"},{"id":383,"title":"Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis"},{"id":384,"title":"Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease "},{"id":386,"title":"Deposition of ionizing energy leading to population decline via inhibition of photosynthesis"},{"id":387,"title":"Deposition of ionising energy leading to population decline via mitochondrial dysfunction"}]}